microRNA-141-3p fosters the growth, invasion, and tumorigenesis of cervical cancer cells by targeting FOXA2

Li, Jia-heng; Zhang, Zhan; Du, Muying; Guan, Yichun; Yao, Jianning; Yu, Haiyang; Wang, Bijun; Wang, Xingling; Wu, Sheling; Li, Zhen

doi:10.1016/j.abb.2018.09.008

Cited by 46 publications

(29 citation statements)

References 26 publications

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“…18,29,30 In addition, miR-141-3p has been reported to foster cell growth, invasion, and tumorigenesis of cervical cancer by targeting FOXA2. 31 MiR-92a was found to promote the proliferation and invasion of hepatocellular carcinoma cells by regulating FOXA2. 32 These findings support our conclusion that miR-1246 promotes cell viability and metastasis in melanoma by targeting FOXA2.…”

Section: Discussionmentioning

confidence: 98%

<p>MicroRNA-1246 Promotes Melanoma Progression Through Targeting FOXA2</p>

Yu¹,

Yu²,

Sun³

2020

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Section: Discussionmentioning

confidence: 98%

<p>MicroRNA-1246 Promotes Melanoma Progression Through Targeting FOXA2</p>

Yu¹,

Yu²,

Sun³

2020

OTT

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“…MiRNAs exert important functions with respect to the occurrence and progression of various cancers 14 . MiR‐141‐3p promotes the proliferative capacities in CC by targeting FOXA2 15 . MiR‐638 suppresses the metastasis by activating the WNT signaling pathway in CC 16 .…”

Section: Introductionmentioning

confidence: 99%

LINC00641 hinders the progression of cervical cancer by targeting miR‐378a‐3p/CPEB3

Zhang

2020

The Journal of Gene Medicine

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Background LINC00641 was found to act in anti‐tumor manner in several types of cancers. Nonetheless, the detailed functions of LINC00641 have not been determined in cervical cancer (CC). Methods The expression of LINC00641, miR‐378a‐3p and CPEB3 was examined using a quantitative reverse transcriptase‐polymerase chain reaction. The relationships between LINC00641 and its downstream mechanism were illustrated by RNA pull‐down and luciferase reporter experiments. Results LINC00641 was found to be under‐expressed in CC cell lines. By overexpressing LINC00641, cell proliferative, migratory and invasive abilities, as well as epithelial mesenchymal transition (EMT) characteristics, were inhibited, whereas the rate of apoptosis was increased. Next, a starBase search (http://starbase.sysu.edu.cn) was applied to select microRNAs that had binding sequences with LINC00641. By up‐regulating LINC00641 expression, miR‐378a‐3p expression displayed the strongest decline. Moreover, miR‐378a‐3p was found to be up‐regulated in CC cell lines. In addition, LINC00641 hindered the progression of CC by decreasing miR‐378a‐3p expression. CPEB3 was discovered as a downstream target of miR‐378a‐3p and was under‐expressed in CC cells. Furthermore, knockdown of CPEB3 could counter the influence of an overexpression of LINC00641 with respect to CC progression. Conclusions LINC00641 suppressed the progression of CC by targeting miR‐378a‐3p/CPEB3, suggesting that LINC00641 may have positive therapeutic impact for treatment for CC.

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“…Dysregulation of miRNAs has been widely reported in cervical cancer, and dysregulated miRNAs play crucial roles in cervical cancer carcinogenesis and progression (26)(27)(28)(29). miRNAs are able to regulate all major cancer-associated biological behaviors in cervical cancer, including differentiation, proliferation, the cell cycle, apoptosis, migration and metastasis (30)(31)(32). Hence, investigating the detailed roles of miRNAs that are aberrantly expressed in cervical cancer and the involved molecular mechanisms is essential for early diagnosis and effective therapeutic approaches.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑877 is downregulated in cervical cancer and directly targets MACC1 to inhibit cell proliferation and invasion

et al. 2019

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Previously, a number of microRNAs (miRNAs) have been reported to be dysregulated in cervical cancer, and dysregulated miRNAs may play crucial roles in the development and progression of cervical cancer. Hence, investigating the detailed roles of miRNAs that are aberrantly expressed in cervical cancer and the underlying molecular mechanisms is essential for early diagnosis and effective therapeutic approaches. miRNA-877 (miR-877) was found to be downregulated in hepatocellular carcinoma and renal cell carcinoma, and function as a tumor-suppressive miRNA. However, how miR-877 exerts an effect in cervical cancer progression and its underlying molecular mechanisms remains to be elucidated. In the current study, reverse transcription-quantitative PCR was performed to determine miR-877 expression in cervical cancer tissues and cell lines. The effects of miR-877 overexpression on cervical cancer cell proliferation and invasion were evaluated using MTT and Transwell cell invasion assays. In the present study, miR-877 was significantly downregulated in cervical cancer tissues and cell lines, and the decreased expression levels of miR-877 were significantly associated with increased International Federation of Gynecology and Obstetric stage as well as increased lymph node metastasis in patients with cervical cancer. Upregulation of miR-877 using miR-877 mimics resulted in the decreased proliferation and invasion of cervical cancer cells. Metastasis-associated in colon cancer-1 (MACC1) was assessed using bioinformatics analyses to determine whether it could be a potential target gene of miR-877, and the results were confirmed using a luciferase reporter assay. Furthermore, MACC1 was markedly upregulated in cervical cancer tissues, and its level was negatively correlated with the miR-877 level. Overexpression of miR-877 resulted in decreased expression levels of MACC1 in cervical cancer cells at both the mRNA and protein levels. In addition, the functional effects of MACC1 knockdown were similar to those induced by upregulated miR-877 in cervical cancer cells. MACC1 restored miR-877 overexpression-mediated suppression of cervical cancer cell proliferation and invasion. In conclusion, miR-877 may play an antitumor role in cervical cancer by directly targeting MACC1, which suggests that this miRNA may be a promising therapeutic target for the treatment of patients with such an aggressive gynecological cancer.

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microRNA-141-3p fosters the growth, invasion, and tumorigenesis of cervical cancer cells by targeting FOXA2

Cited by 46 publications

References 26 publications

<p>MicroRNA-1246 Promotes Melanoma Progression Through Targeting FOXA2</p>

<p>MicroRNA-1246 Promotes Melanoma Progression Through Targeting FOXA2</p>

LINC00641 hinders the progression of cervical cancer by targeting miR‐378a‐3p/CPEB3

MicroRNA‑877 is downregulated in cervical cancer and directly targets MACC1 to inhibit cell proliferation and invasion

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