MicroRNA-142-3p is frequently upregulated in colorectal cancer and may be involved in the regulation of cell proliferation

Zhou, Jialiang; Jiang, Zhi Hong; Wang, Zhengwu; Zou, Shitao; Zhang, Yunxia; Cai, Wei; Wang, Ming Zhi; Xu, Min; Shi, Daren; Chen, Weichang

doi:10.1007/s11434-013-5937-5

Cited by 8 publications

(9 citation statements)

References 33 publications

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“…Upregulation of these genes are associated with poor prognosis in colon cancer. In addition Zhou et al found that miR-142-3p may be involved in the regulation of cell proliferation in colorectal cancer through targeting the transcription factor 7 (TCF7) ( 30 ). Another previous study revealed that miR-142-3p could regulate FASN expression which is involved in cancer cells proliferation and metastasis in CRC ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Downregulation of Plasma MiR-142-3p and MiR-26a-5p in Patients With Colorectal Carcinoma

Ghanbari

Mosakhani

Asadi

et al. 2015

Iran J Cancer Preven

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Background:Colorectal cancer is one of the most commonly diagnosed cancers and cancer- related death worldwide. Identification of new specific biomarkers could be helpful to detection of this malignancy. Altered plasma microRNA expression has been identified in many cancers, including colorectal cancer.Objectives:The main objective of this study was to identify the circulating microRNAs with the most expression changes in colorectal cancer patients compared with neoplasm free healthy individuals.Materials and Methods:MicroRNA expression profiling was performed on plasma samples of 37 colorectal cancer patients and 8 normal subjects using microRNA microarray. Quantitative real-time reverse transcription polymerase chain reaction was used to validate the two selected altered microR NAs. Plasma samples from 61 colorectal cancer patients and 24 normal subjects were used in our validation study.Results:In profiling study we found a panel of six plasma microRNAs with significant downregulation. MicroRNA-142-3p and microRNA-26a-5p were selected and validated by polymerase chain reaction. Our results demonstrated that expression levels of plasma microRNA-142-3p and microRNA-26a-5p were significantly downregulated in patients with colorectal cancer when compared to control group.Conclusions:Our findings suggest that downregulation of plasma microRNA-142-3p and microRNA-26a-5p might serve as novel noninvasive biomarkers in the diagnosis of colorectal cancer, although more studies are needed to highlight the theoretical strengths.

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Section: Discussionmentioning

confidence: 99%

Downregulation of Plasma MiR-142-3p and MiR-26a-5p in Patients With Colorectal Carcinoma

Ghanbari

Mosakhani

Asadi

et al. 2015

Iran J Cancer Preven

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“…miRNAs are epigenetic regulators which bind to the 3'-untranslated regions of their target mRNAs and degrade them or repress their translation (9,12). In various cancer types, certain miRNAs are aberrantly expressed and act as oncogenes or tumor suppressors (13)(14)(15). Due to the imperfect complementarity between miRNAs and their target mRNAs, each mRNA may be regulated by various miRNAs and each miRNA may target various mRNAs (16,17).…”

Section: Introductionmentioning

confidence: 99%

Tumor suppressive miR-196a is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma

Jin

CHEN

et al. 2016

Molecular Medicine Reports

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Certain microRNAs (miRs) are implicated in the genesis and progression of various cancers by regulating multiple cellular processes, including apoptosis, proliferation and migration. The aim of the present study was to explore the functions of miR‑196a in renal cell carcinoma (RCC). RCC and paired normal tissues we assessed for miR‑196a expression by reverse-transcription quantitative PCR. Furthermore, the effects of miR‑196a on renal cell proliferation, apoptosis and migration were determined using an MTT assay, flow cytometry and a scratch wound assay following restoration of miR-196a with synthetic mimics. miR‑196a was found to be significantly downregulated in RCC tissues compared with that in normal tissues (P<0.05). In addition, miR‑196a suppressed cell proliferation, apoptosis and migration of the 786‑O and ACHN RCC cell lines. To the best of our knowledge, the present study was the first to report this tumor suppressor role of miR‑196a in RCC. The results indicated that miR‑196a may be a potential diagnostic biomarker for RCC and that transfection of miR-196a mimics may represent a novel treatment strategy for RCC.

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“… 10 Next, we confirmed upregulation of miR-142-3p in CRC samples and cell lines and its involvement in the regulation of cell proliferation. 11 The present study establishes the oncogenic function of miR-142-3p in CRC, demonstrating how it regulates cell migration and influences the overall survival (OS) in patient with CRC.…”

Section: Introductionmentioning

confidence: 53%

MicroRNA-142-3p Promotes Cellular Invasion of Colorectal Cancer Cells by Activation of RAC1

Gao

et al. 2018

Technol Cancer Res Treat

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Background:Colorectal cancer has been proved more difficult to treat owing to potently malignant metastasis. The present study was aimed to explore the functional role of miR-142-3p in cell migration and invasion of colorectal cancer cells, as well as its underlying mechanism.Materials and Methods:Expressions of miR-142-3p were analyzed in colorectal cancer tissues and cell lines. Ras-related C3 botulinum toxin substrate 1 (RAC1) was predicted as a target of miR-142-3p using software and network resources. SW480 cells were transfected with miR-142-3p expression plasmid and miR-142-3p silencer plasmid, and the expression of RAC1 and the cellular invasion were measured.Results:In colorectal cancer cells transfected with miR-142-3p expression plasmid, RAC1 was specifically upregulated and invasiveness of cells was downregulated. Moreover, RAC1 was significantly associated with tumor stage (P = .029) and tumor metastasis (P = .012).Conclusion:miR-142-3p promotes cellular invasion in colorectal cancer cells by activating RAC1. Thereby, miR-142-3p is a potential candidate for molecular targeted therapy of colorectal cancer.

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MicroRNA-142-3p is frequently upregulated in colorectal cancer and may be involved in the regulation of cell proliferation

Cited by 8 publications

References 33 publications

Downregulation of Plasma MiR-142-3p and MiR-26a-5p in Patients With Colorectal Carcinoma

Downregulation of Plasma MiR-142-3p and MiR-26a-5p in Patients With Colorectal Carcinoma

Tumor suppressive miR-196a is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma

MicroRNA-142-3p Promotes Cellular Invasion of Colorectal Cancer Cells by Activation of RAC1

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