MicroRNA-143 inhibits cell migration and invasion by targeting matrix metalloproteinase 13 in prostate cancer

Wu, Donghai; Huang, Ping; Wang, Linmao; Zhou, Yifei; Pan, Huixing; Qü, Ping

doi:10.3892/mmr.2013.1501

Cited by 47 publications

(29 citation statements)

References 25 publications

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“…translations, which play important roles in tumor cell proliferation and neoangiogenesis. Their lowered expression rates were identified in HPV associated head and neck cancers (23)(24)(25)(26)(27)(28). In our study these miRNAs also showed lowered expression rates.…”

Section: Discussionsupporting

confidence: 48%

Comparative miRNA Expression Profile Analysis of Squamous Cell Carcinoma and Peritumoral Mucosa from the Meso- and Hypopharynx

Orosz

Gombos

Riedling³

et al. 2017

CGP

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Abstract. Background In Europe, according to the age-standardized rates per 100,000 population, Hungary had the highest estimated incidence, mortality and prevalence in lip, oral cavity and pharyngeal cancers for both sexes. Based on the cancer registerty held by the National Institute of Oncology, in 2010 and 2011 meso-and hypopharyngeal carcinomas counted more than 1,200 cases. The number of diagnosed mesopharyngeal carcinomas in our clinical site has doubled, while hypopharyngeal carcinoma cases have tripled since 1983 (Figures 1 and 2). Incidence of meso-and hypopharyngeal carcinomas is constantly growing, while the rate of mortality is above 50% due to late-stage recognition. In our clinical practice, malignant cancers of the meso-and hypopharyngeal regions are most specific in the 55-60 age range population, although the appearance of the different pharyngeal carcinomas has been observed in a growing number at younger ages in the past few years. It is important to note that the cancers affecting only one region, having good operability options and a better prognosis are disappearing, while the ones involving more than one region, with aggressive spreading and progressive prognosis are becoming more frequent. Our goal was to find and study a molecular marker that could be used as a predictive and a prognostic tool to complete clinical diagnostics.In recent years micro-RNAs (miRNA) have been excessively studied. These small, 19-25 base-pair-long RNAs are transcribed from an intra-or intergenic segment of DNA and are not translated into proteins. Matured miRNA binds to a ribonucleotid complex, called RISC (RNA induced silencing complex), and drives the regulation of mRNA translation, either by binding to the target mRNA's 3' UTR (untranslated region) segment, or to 5' UTR or just directly to the ORF (open reading frame). This way translation is blocked or endonucleases are activated causing the degradation of mRNA target (1, 2). An estimated 50-60% of the human genome is regulated by miRNAs. A specific mRNA can be regulated by multiple miRNAs, and a miRNA can modulate translation of more then hundred mRNAs (1). This RNA interference mechanism establishes precise modulation of gene expression, harmonic regulation of cellular functions as cell division, differentiation, apoptosis and intermediary metabolism (3). miRNAs can behave either as oncogenes (oncomirs) or tumor suppressors according to which target mRNA is regulated by them (1). miRNAs can be detected in blood serum, saliva and other body fluids (4-285

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Section: Discussionsupporting

confidence: 48%

Comparative miRNA Expression Profile Analysis of Squamous Cell Carcinoma and Peritumoral Mucosa from the Meso- and Hypopharynx

Orosz

Gombos

Riedling³

et al. 2017

CGP

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“…MMPs have a significant role in cancer metastasis (37). The activities of MMP-2 and MMP-9 are associated with the adhesion, invasion and angiogenesis of cancer metastasis (38,39).…”

Section: Discussionmentioning

confidence: 99%

Ophiopogonin-D suppresses MDA-MB-435 cell adhesion and invasion by inhibiting matrix metalloproteinase-9

Zhang

Han

Zhai

et al. 2012

Molecular Medicine Reports

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Ophiopogonin-D is one of steroidal saponins isolated from the root of the Chinese medicinal plant Ophiopogon japonicas. It has been claimed to possess anti-inflammatory and anti-oxidant properties. The present study was the first to examine the anti-tumor metastasis properties of ophiopogonin-D. An MTT assay showed that ophiopogonin-D inhibited the proliferation of MDA-MB-435 melanoma cells, and decreased invasion was demonstrated using a Transwell invasion assay. Furthermore, adhesion of MDA-MB-435 cells to human umbilical vascular endothelial cells and to fibronectin was inhibited by ophiopogonin-D. Gelatin zymography and western blot analysis showed that ophiopogonin-D inhibited the expression and secretion of matrix metalloproteinase-9 (MMP-9), but not that of MMP-2. Inhibition of phosphorylation of p38 by ophiopogonin-D indicated its inhibition of the mitogen-activated protein kinase pathway. Overall, the results suggested that ophiopogonin-D may be considered as a candidate drug for treating or preventing tumor metastasis.

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“…Knockdown of FSCN1 and SWAP70 suppresses cell migration and invasion in PCa cells, and reconstitution of these genes rescues the inhibited cell growth induced by miR-145 (44,45). In an attempt to screen targets of miR-143 involved in cell migration and invasion, metalloproteinase 13 (MMP-13) was found to be a direct target gene of miR-143 (46). Joint down-regulation of miR-143 and miR-145 also enhances cancer cell migration and invasion in vitro and in vivo through increased expression of the mesenchymal marker fibronectin and the reduced expression of E-cadherin (47), thereby promoting the EMT phenotype.…”

Section: Mir-143 and Mir-145mentioning

confidence: 98%

Microdissecting the role of microRNAs in the pathogenesis of prostate cancer

2015

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MicroRNA-143 inhibits cell migration and invasion by targeting matrix metalloproteinase 13 in prostate cancer

Cited by 47 publications

References 25 publications

Comparative miRNA Expression Profile Analysis of Squamous Cell Carcinoma and Peritumoral Mucosa from the Meso- and Hypopharynx

Comparative miRNA Expression Profile Analysis of Squamous Cell Carcinoma and Peritumoral Mucosa from the Meso- and Hypopharynx

Ophiopogonin-D suppresses MDA-MB-435 cell adhesion and invasion by inhibiting matrix metalloproteinase-9

Microdissecting the role of microRNAs in the pathogenesis of prostate cancer

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