MicroRNA-144 Regulates Cardiomyocyte Proliferation and Apoptosis by Targeting &lt;b&gt;&lt;i&gt;TBX1&lt;/i&gt;&lt;/b&gt; through the JAK2/STAT1 Pathway

Cao, Meiling; Zhu, Binlu; Sun, Yuanyuan; Qiu, Guang-Rong; Fu, Wei; Jiang, Hongkun

doi:10.1159/000505143

Cited by 13 publications

(9 citation statements)

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“…The data of Figures 3 and 4 indicate that exposure to CoV induces plasma cell apoptosis and suppresses SOD in plasma cells. As the Janus kinase (JAK)2/STAT1 (signal transducer and activator of transcription 1) pathway activation is associated with cell apoptosis initiation [ 9 ], the JAK2/STAT1 activation in sPCs was assessed after exposing to CoV overnight. The results showed that CoV exposure markedly induced the JAK2 and STAT1 phosphorylation in sPCs (Figures 5(a) and 5(b) ).…”

Section: Resultsmentioning

confidence: 99%

Superoxide Dismutase Prevents SARS-CoV-2-Induced Plasma Cell Apoptosis and Stabilizes Specific Antibody Induction

Luo

et al. 2022

Oxidative Medicine and Cellular Longevity

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The infection of coronavirus disease (COVID-19) seriously threatens human life. It is urgent to generate effective and safe specific antibodies (Abs) against the pathogenic elements of COVID-19. Mice were immunized with SARS-CoV-2 spike protein antigens: S ectodomain-1 (CoV, in short) mixed in Alum adjuvant for 2 times and boosted with CoV weekly for 6 times. A portion of mice were treated with Maotai liquor (MTL, in short) or/and heat stress (HS) together with CoV boosting. We observed that the anti-CoV Ab was successfully induced in mice that received the CoV/Alum immunization for 2 times. However, upon boosting with CoV, the CoV Ab production diminished progressively; spleen CoV Ab-producing plasma cell counts reduced, in which substantial CoV-specific Ab-producing plasma cells (sPC) were apoptotic. Apparent oxidative stress signs were observed in sPCs; the results were reproduced by exposing sPCs to CoV in the culture. The presence of MTL or/and HS prevented the CoV-induced oxidative stress in sPCs and promoted and stabilized the CoV Ab production in mice in re-exposure to CoV. In summary, CoV/Alum immunization can successfully induce CoV Ab production in mice that declines upon reexposure to CoV. Concurrent administration of MTL/HS stabilizes and promotes the CoV Ab production in mice.

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Section: Resultsmentioning

confidence: 99%

Superoxide Dismutase Prevents SARS-CoV-2-Induced Plasma Cell Apoptosis and Stabilizes Specific Antibody Induction

Luo

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…It corroborates a prior study where Prkar2a has been indicated to reversely regulate the JAK2/STAT1 signaling pathway [ 17 ]. Notably, the activation of the JAK2/STAT1 signaling pathway has been reported to be involved in cell apoptosis [ 19 , 39 ]. Importantly, inactivated JAK2/STAT1 due to GJ-4 was found to improve memory impairment in focal CI/reperfusion in rats [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Circ_0000811 acts as a miR-15b sponge and inhibits Prkar2a-mediated JAK2/STAT1 pathway to attenuate cerebral ischemic vertigo

Huang

Han

et al. 2022

Cell Death Discov.

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Circular RNAs (circRNAs) have been noted to express in the brain and thus participate in various diseases related to the central nervous system. However, the potential role of circRNAs in cerebral ischemia (CI)-induced vertigo remains unknown. We initially predicted through bioinformatics analysis the poor expression of circ_0000811 related to CI. A mouse model of CI-induced vertigo was then established, which was validated by measurement of escape latency and medial vestibular nucleus (MVN) blood flow, with NeuN/Annexin counterstaining utilized to detect cell apoptosis in the MVN. An oxygen glucose deprivation (OGD)-exposed neuron-like cell model was further established for in vitro gain- and loss- of function assays, with flow cytometry performed to detect cell apoptosis. The poorly expressed circ_0000811, up-regulated miR-15b expression, and down-regulated Prkar2a expression were observed in both mice with CI-induced vertigo and OGD-exposed cells. Our data then demonstrated that circ_0000811 restoration alleviated CI-induced vertigo in mouse models, and that circ_0000811 acted as a miR-15b sponge to inhibit miR-15b expression. Prkar2a was validated as the target gene of miR-15b. Prkar2a restoration was subsequently revealed to repress OGD-induced neuronal apoptosis through JAK2/STAT1 signaling pathway inactivation. Furthermore, inactivation of the JAK2/STAT1 signaling pathway exerted an anti-apoptotic effect in OGD-induced neurons and an alleviatory effect in mice with CI-induced vertigo with Prkar2a overexpression and circ_0000811 overexpression. Taken together, our work suggests that circ_0000811 is involved in neuronal apoptosis of CI-induced vertigo and may be used as a biomarker for ameliorating CI-induced vertigo.

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“…Although Tbx1 is currently described as one of the core genes implicated in congenital heart disease (CHD), the molecular mechanisms underlying its role in the pathogenesis of this abnormality is not fully understood [345]. Recent studies, described by Cao et al [346] showed that miR-144 inhibits cardiomyocyte proliferation and promotes cardiomyocyte apoptosis by targeting the 3 UTR of Tbx1 via regulating Jak2/Stat1 signaling pathway (Figure 3B,C).…”

Section: Post-transcriptional Control Of Aortic Arch Development By N...mentioning

confidence: 99%

Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis

Lozano-Velasco

García-Padilla

Muñoz-Gallardo

et al. 2022

IJMS

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Cardiovascular development is initiated soon after gastrulation as bilateral precardiac mesoderm is progressively symmetrically determined at both sides of the developing embryo. The precardiac mesoderm subsequently fused at the embryonic midline constituting an embryonic linear heart tube. As development progress, the embryonic heart displays the first sign of left-right asymmetric morphology by the invariably rightward looping of the initial heart tube and prospective embryonic ventricular and atrial chambers emerged. As cardiac development progresses, the atrial and ventricular chambers enlarged and distinct left and right compartments emerge as consequence of the formation of the interatrial and interventricular septa, respectively. The last steps of cardiac morphogenesis are represented by the completion of atrial and ventricular septation, resulting in the configuration of a double circuitry with distinct systemic and pulmonary chambers, each of them with distinct inlets and outlets connections. Over the last decade, our understanding of the contribution of multiple growth factor signaling cascades such as Tgf-beta, Bmp and Wnt signaling as well as of transcriptional regulators to cardiac morphogenesis have greatly enlarged. Recently, a novel layer of complexity has emerged with the discovery of non-coding RNAs, particularly microRNAs and lncRNAs. Herein, we provide a state-of-the-art review of the contribution of non-coding RNAs during cardiac development. microRNAs and lncRNAs have been reported to functional modulate all stages of cardiac morphogenesis, spanning from lateral plate mesoderm formation to outflow tract septation, by modulating major growth factor signaling pathways as well as those transcriptional regulators involved in cardiac development.

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MicroRNA-144 Regulates Cardiomyocyte Proliferation and Apoptosis by Targeting <b><i>TBX1</i></b> through the JAK2/STAT1 Pathway

Cited by 13 publications

References 0 publications

Superoxide Dismutase Prevents SARS-CoV-2-Induced Plasma Cell Apoptosis and Stabilizes Specific Antibody Induction

Superoxide Dismutase Prevents SARS-CoV-2-Induced Plasma Cell Apoptosis and Stabilizes Specific Antibody Induction

Circ_0000811 acts as a miR-15b sponge and inhibits Prkar2a-mediated JAK2/STAT1 pathway to attenuate cerebral ischemic vertigo

Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis

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