MicroRNA-145 inhibits lung cancer cell metastasis

Ling, Dong‐Jin; Chen, Zhongshu; Yang-de, Zhang; Liao, Qiande; Feng, Jian‐Xiong; Zhang, Xue‐Yu; Shi, Tian‐Sheng

doi:10.3892/mmr.2014.3036

Cited by 28 publications

(21 citation statements)

References 34 publications

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“…Our observation was closely consistent with a recently published report demonstrating that UCA1 promoted bladder cancer cell migration and invasion by the hsa-mir145-ZEB1/2-FSCN1 pathway (24). Similar to miR-143, miR-145 was also reported to be a tumor suppressive gene and a negative regulator of EMT (47)(48)(49). Thus, UCA1 might function as an oncogene by sponging EMT-related miRNAs.…”

Section: Discussionsupporting

confidence: 81%

LncRNA UCA1 promotes the invasion and EMT of bladder cancer cells by regulating the miR‑143/HMGB1 pathway

Luo

Chen

et al. 2017

Oncol Lett

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Abstract. The long non-coding RNA (lncRNA) urothelial carcinoma associated 1 (UCA1) is an oncogenic lncRNA in bladder cancer, and its upregulation is associated with enhanced cell invasion. However, the underlying mechanism remains to be elucidated. The present study demonstrated that UCA1 was positively associated with cell invasion ability and promoted epithelial-mesenchymal transition (EMT) of bladder cancer cells by inducing high mobility group box 1 (HMGB1). Furthermore, bioinformatics and luciferase reporter assays demonstrated binding sites of the tumor suppressive miR-143 within UCA1 and the 3'untranslated region of HMGB1. UCA1 negatively regulated miR-143 expression in a dose-dependent manner in bladder cancer cells. In addition, UCA1 and HMGB1 were upregulated and miR-143 was downregulated in bladder cancer specimens. Overall, the data suggested that UCA1 may promote the invasion and EMT of bladder cancer cells by regulating the miR-143/HMGB1 pathway, which exhibits an important regulatory role in the pathology of bladder cancer.

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Section: Discussionsupporting

confidence: 81%

LncRNA UCA1 promotes the invasion and EMT of bladder cancer cells by regulating the miR‑143/HMGB1 pathway

Luo

Chen

et al. 2017

Oncol Lett

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“…These results demonstrate that miR-664 may serve an important role in lung cancer. The risk of distant metastasis of lung cancer is high and once metastasis occurs, it may become an incurable disease with limited survival time (29). The EMT serves an important role in metastasis and allows epithelial cells to lose their epithelial characteristics and acquire a mesenchymal phenotype (30).…”

Section: Discussionmentioning

confidence: 99%

microRNA-664 enhances proliferation, migration and invasion of lung cancer cells

Zhu

Yuan

et al. 2017

Experimental and Therapeutic Medicine

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Altered microRNA (miR) expression serves an important role in the development and progression of lung cancer. In the present study, the effect of miR-664 on proliferation, migration and invasion of lung cancer cells was assessed. The proliferation of lung cancer cells with an overexpression of miR-664 was examined via MTT assay. The Caspase-Glo3/7 assay was used to examine the effect of miR-664 on cisplatin-induced apoptosis in lung cancer cells. The migration and invasion of lung cancer cells were assessed by Transwell migration and matrigel invasion assays. Western blot analysis was used to examine the protein expression levels. miR-664 improved the proliferation of lung cancer cells and inhibited cisplatin-induced apoptosis of A549 and A427 cells. Furthermore, altered expression of miR-664 affected migration and invasion of lung cancer cells. In addition, a miR-664 mimic decreased E-cadherin expression and increased vementin and Snail expression in lung cancer cells. Notably, the expression level of protein kinase B in A549 cells was changed following altered expression of miR-664. The results of the present study suggest that miR-664 serves an essential role in tumor development and progression in lung cancer.

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“…Through further qRT-PCR validation, overexpressed miR-1260b was demonstrated in LN metastasis tissue of NSCLC patients compared with LN free NSCLC patients. A variety of studies have identified certain miRNAs that suppress the metastasis in lung cancer [9,10,21]. Let-7 is one of the earliest identified miRNAs with significantly reduced expression in a large number of malignant tumors and is known to attenuate the development of lung cancer [22,23].…”

Section: Discussionmentioning

confidence: 99%

“…Human microRNA genes are frequently located at cancer-associated genomic regions or in fragile sites [8]. In recent studies, several miRNAs such as miR-145, miR-186 and the let-7 family were considered suppressors for the metastasis and epithelial mesenchymal transition (EMT) in lung cancer [2,9,10] while miR-10b and miR-155 were positively correlated with the NSCLC tumorous process [11,12]. Therefore, there is a need to investigate the specific miRNAs as putative indicators for NSCLC metastasis more comprehensively and provide a sensitive method for the early diagnosis of NSCLC.…”

mentioning

confidence: 99%

Overexpression of miR-1260b in Non-small Cell Lung Cancer is Associated with Lymph Node Metastasis

Xu¹,

Li²,

Li³

et al. 2015

Aging and disease

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Lymph node (LN) metastasis is often an early event in the progression of malignant tumors and it contributes to the majority of cancer mortalities. MiRNAs play key roles in tumor metastasis. This study aimed to investigate the specific miRNAs as putative indicators of metastasis early diagnosis for non-small cell lung cancer (NSCLC). In this study, five NSCLC cases with LN metastasis and four cases without metastasis (NLN) were enrolled for Agilent Human miRNA array. The interested differentially expressed miRNA was validated by quantitative reverse transcription polymerase chain reaction (qRT-PCR) in the LN metastasis (n = 46) and NLN (n = 39) groups. The microarray results revealed that three miRNAs (miR-1260b, miR-423-3p, miR-23a-5p) were differentially expressed in LN metastasis group compared with NLN group. The expression of miR-1260b was tested by qRT-PCR and the mean relative expression fold change (2 -ΔΔCt ) in LN metastasis was significantly higher than that in the NLN group (3.942, 1.743 respectively, P = 1.179E-04). The patients with tumor-node-metastasis (TNM) stage III were identified more frequently in LN metastasis group (P = 1.772E-11) and with a higher expression level of miR-1260b (5.126, P = 1.147E-06). In addition, the LN metastasis cases were associated with a poorly differentiated degree (P = 0.007). The overexpression of miR1260b in NSCLC with LN metastasis can be regarded as a specific signature for early progression and prognosis of NSCLC.

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MicroRNA-145 inhibits lung cancer cell metastasis

Cited by 28 publications

References 34 publications

LncRNA UCA1 promotes the invasion and EMT of bladder cancer cells by regulating the miR‑143/HMGB1 pathway

LncRNA UCA1 promotes the invasion and EMT of bladder cancer cells by regulating the miR‑143/HMGB1 pathway

microRNA-664 enhances proliferation, migration and invasion of lung cancer cells

Overexpression of miR-1260b in Non-small Cell Lung Cancer is Associated with Lymph Node Metastasis

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