MicroRNA-183 promotes the proliferation and metastasis of renal cell carcinoma through targeting Dickkopf‑related protein 3

Zhang, Xiaolong; Xu, Gang; Zhou, Yi; Yan, Jiajun

doi:10.3892/ol.2018.7998

Cited by 14 publications

(16 citation statements)

References 27 publications

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“…To our knowledge, the TSC1‐mTOR signaling pathway plays important roles in the regulation of cell growth and proliferation, but little is known about the regulation of cell invasion activities. It should also be noted that the target prediction programs predicted miR‐92b‐3p‐putative binding sequences in other genes involved in the invasion in RCC: PTE and Dickkopf‐related protein‐3 ( DKK‐3 ) . As a single miRNA can regulate multiple protein‐coding and noncoding RNA transcripts in cells, miR‐92b‐3p could also mediate RCC cell invasion activities through other target molecules.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‐92b‐3p is a prognostic oncomiR that targets TSC1 in clear cell renal cell carcinoma

et al. 2020

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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractAlthough several studies have reported that microRNA (miR)-92b-3p is involved in various cellular processes related to carcinogenesis, its physiological role in clear cell renal cell carcinoma (ccRCC) remains unclear. To clarify the role of miR-92b-3p in ccRCC, we compared miR-92b-3p expression levels in ccRCC tissues and adjacent normal renal tissues. Significant upregulation of miR-92b-3p was observed in ccRCC tissues. Overexpression of miR-92b-3p using a miRNA mimic promoted proliferation, migration, and invasion activities of ACHN cells. Functional inhibition of miR-92b-3p by a hairpin miRNA inhibitor suppressed Caki-2 cell growth and invasion activities in vitro. Mechanistically, it was found that miR-92b-3p directly targeted the TSC1 gene, a known upstream regulator of mTOR. Overexpression of miR-92b-3p decreased the protein expression of TSC1 and enhanced the downstream phosphorylation of p70S6 kinase, suggesting that the mTOR signaling pathway was activated by miR-92b-3p in RCC cells. Importantly, a multivariate Cox proportion hazard model, based on TNM staging and high levels of miR-92b-3p, revealed that miR-92b-3p expression (high vs.low hazard ratio, 2.86; 95% confidence interval, 1.20-6.83; P = .018) was a significant prognostic factor for overall survival of ccRCC patients with surgical management.Taken together, miR-92b-3p was found to act as an oncomiR, promoting cell proliferation by downregulating TSC1 in ccRCC. K E Y W O R D SccRCC, miR-92b-3p, oncomiR, proliferation, TSC1

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Section: Discussionmentioning

confidence: 99%

MicroRNA‐92b‐3p is a prognostic oncomiR that targets TSC1 in clear cell renal cell carcinoma

et al. 2020

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“…miR-183 belongs to the miR-183-96-182 cluster, which has an upregulated expression in many solid tumors, including RCC [72]. The expression of miR-183 was increased in tumor specimens compared to their healthy counterparts and its role in promoting invasion and metastasis was demonstrated in RCC lines [80]. Indeed, high levels of miR-183 were also detected in the sera from RCC patients and was inversely correlated with the cytotoxicity of NKs compared to tumor cells in vitro, thus suggesting a possible application of miR-183 detection in patients’ sera as a prognostic marker for immunotherapy [80].…”

Section: Effects Of Rcc-derived Evsmentioning

confidence: 99%

“…The expression of miR-183 was increased in tumor specimens compared to their healthy counterparts and its role in promoting invasion and metastasis was demonstrated in RCC lines [80]. Indeed, high levels of miR-183 were also detected in the sera from RCC patients and was inversely correlated with the cytotoxicity of NKs compared to tumor cells in vitro, thus suggesting a possible application of miR-183 detection in patients’ sera as a prognostic marker for immunotherapy [80]. Finally, Li et al analysed the sera from 284 RCC patients that underwent nephrectomy and demonstrated a positive correlation between miR-183 level and poor prognosis [81].…”

Section: Effects Of Rcc-derived Evsmentioning

confidence: 99%

Extracellular Vesicles and Carried miRNAs in the Progression of Renal Cell Carcinoma

Grange

Brossa

Bussolati

2019

IJMS

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The formation and maintenance of renal cell carcinomas (RCC) involve many cell types, such as cancer stem and differentiated cells, endothelial cells, fibroblasts and immune cells. These all contribute to the creation of a favorable tumor microenvironment to promote tumor growth and metastasis. Extracellular vesicles (EVs) are considered to be efficient messengers that facilitate the exchange of information within the different tumor cell types. Indeed, tumor EVs display features of their originating cells and force recipient cells towards a pro-tumorigenic phenotype. This review summarizes the recent knowledge related to the biological role of EVs, shed by renal tumor cells and renal cancer stem cells in different aspects of RCC progression, such as angiogenesis, immune escape and tumor growth. Moreover, a specific role for renal cancer stem cell derived EVs is described in the formation of the pre-metastatic niche. We also highlight the tumor EV cargo, especially the oncogenic miRNAs, which are involved in these processes. Finally, the circulating miRNAs appear to be a promising source of biomarkers in RCC.

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“…Renal cell carcinoma (RCC) is one of the most commonly occurring types of tumors in the urogenital system and accounts for~85% of all kidney tumors [1][2][3][4]. RCC is not sensitive to conventional chemotherapy and radiotherapy, and its prognosis remains poor [1]. Prostate cancer (PCa) is a complex disease, and is the fifth leading cause of cancer death in men worldwide [5].…”

Section: Introductionmentioning

confidence: 99%

Association of hypoxia-inducible factor-1α (HIF1α) 1790G/A gene polymorphism with renal cell carcinoma and prostate cancer susceptibility: a meta-analysis

Zhou

Lin

et al. 2019

BMC Med Genet

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Background: This meta-analysis was performed to evaluate the relationship between hypoxia-inducible factor-1α (HIF1α) 1790G/A gene polymorphism and the susceptibility to renal cell carcinoma (RCC) and prostate cancer (PCa). Methods: Association investigations were identified and included from the Embase, Cochrane Library and PubMed databases on March 1, 2018, and eligible investigations were analyzed by meta-analysis. Odds ratios (OR) were used to express the dichotomous data, and the 95% confidence intervals (CI) were also calculated. Results: In this meta-analysis, we found that the AA genotype of HIF1α 1790G/A was positively associated with the risk of RCC in overall populations, Caucasians, but not for Asians. G allele and GG genotype were not associated with the susceptibility of RCC in overall populations, Caucasians, and Asians. The G allele was negatively associated with PCa susceptibility in overall populations, Asians, but not for Caucasians. GG genotype was negatively associated with PCa susceptibility in Asians, but not for overall populations and Caucasians. HIF1α 1790G/A AA genotype was not associated with PCa susceptibility in overall populations of Caucasians or Asians. Conclusion: AA genotype of HIF1α 1790G/A was positively associated with RCC risk in overall populations and Caucasians. Furthermore, the G allele was negatively associated with prostate cancer susceptibility in overall populations, Asians, and GG genotype was negatively associated with PCa susceptibility in Asians.

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MicroRNA-183 promotes the proliferation and metastasis of renal cell carcinoma through targeting Dickkopf‑related protein 3

Cited by 14 publications

References 27 publications

MicroRNA‐92b‐3p is a prognostic oncomiR that targets TSC1 in clear cell renal cell carcinoma

MicroRNA‐92b‐3p is a prognostic oncomiR that targets TSC1 in clear cell renal cell carcinoma

Extracellular Vesicles and Carried miRNAs in the Progression of Renal Cell Carcinoma

Association of hypoxia-inducible factor-1α (HIF1α) 1790G/A gene polymorphism with renal cell carcinoma and prostate cancer susceptibility: a meta-analysis

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