2014
DOI: 10.1038/cddis.2014.148
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MicroRNA-185 regulates chemotherapeutic sensitivity in gastric cancer by targeting apoptosis repressor with caspase recruitment domain

Abstract: Gastric cancer remains the second leading cause of cancer deaths worldwide. Resistance to chemotherapy is a significant barrier for effective cancer treatment. Here, we identified miR-185 to be a contributor to chemosensitivity in gastric cancer. We observed low levels of miR-185 in gastric cancer cell lines and clinical tissues, compared with gastric epithelium cell line and noncancerous tissues. Furthermore, enforced expression of miR-185 increased the sensitivity of gastric cancer cells to low-dose chemothe… Show more

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Cited by 71 publications
(52 citation statements)
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“…In a gastric cancer study, a novel mechanism whereby miR‐185 directly targets apoptosis repressor with caspase recruitment domain (ARC) was revealed. The role of this miRNA was studied in vitro and further validated in a gastric tumor xenograft model …”
Section: Mirnas Are Involved In All Cancer Hallmarksmentioning
confidence: 99%
See 1 more Smart Citation
“…In a gastric cancer study, a novel mechanism whereby miR‐185 directly targets apoptosis repressor with caspase recruitment domain (ARC) was revealed. The role of this miRNA was studied in vitro and further validated in a gastric tumor xenograft model …”
Section: Mirnas Are Involved In All Cancer Hallmarksmentioning
confidence: 99%
“…The role of this miRNA was studied in vitro and further validated in a gastric tumor xenograft model. 71…”
Section: Evasion From Apoptosismentioning
confidence: 99%
“…MicroRNAs (miRNAs) are a family of small, non-coding RNAs that negatively regulate the expression of target genes by altering mRNA translation or stability [4]. miRNAs play important roles in a wide variety of physiological or pathological processes, including tumorigenesis.…”
Section: Introductionmentioning
confidence: 99%
“…As the enzymatic product of SPS-2 is part of the selenoprotein biosynthesis machinery, these findings indicate that Se availability affects the selenoproteome in part through epigenetic mechanisms involving miRNA-185 and possibly other miRNAs. miRNA-185 is a particularly interesting target of Se, as it has recently emerged as a tumor suppressor that is frequently downregulated in ovarian, breast, renal, 81 prostate, 82 and gastric cancers, 83 and targets oncogenes, e.g., Six1, 81 androgen receptor, 82 and apoptosis repressor with caspase recruitment domain (ARC). 83 Se has been shown to act anticarcinogenic in experimental settings and also in some human studies ( 18 for an overview); it will therefore be an interesting area of future work to uncover putative roles of miRNAs as mediators of Se-dependent tumor protection against malignant transformation.…”
Section: Regulation Of Microrna Expression By Seleniummentioning
confidence: 99%