MicroRNA-193-5p modulates angiogenesis through IGF2 in type 2 diabetic cardiomyopathy

Fan, Yi; Shang, Yalei; Li, Bing; Dai, Shilin; Wu, Wei; Cheng, Long; Wang, Xiancan

doi:10.1016/j.bbrc.2017.07.108

Cited by 25 publications

(25 citation statements)

References 24 publications

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“…It is well known that microRNAs (miRNAs) are an emerging group of gene expression modulators with critical roles in several biological processes like cell proliferation, apoptosis, differentiation, cell cycle progression, and organ development (Iorio, Casalini, Piovan, Braccioli, & Tagliabue, ; Rothschild, ; Singh & Mo, ; van Schooneveld et al, ). Additionally, it was proposed that these tiny molecules are involved in processes linked to formation and progression of various tumors and even development of different diseases such as Alzheimer’s, autism, fragile X syndrome, diabetes as well as heart diseases and allergic conditions (Mansoori et al, ; Mohammadi, Mansoori, & Baradaran, ; F. Yi et al, ). In the cancer cascade, miRNAs act mainly as oncogenes (oncomiRs) or tumor suppressors and miRNA profiling experiments demonstrated dysregulation of miRNAs in cancers when compared with normal tissues (Mansoori, Mohammadi, Shirjang, & Baradaran, ; Rothschild, ).…”

Section: Introductionmentioning

confidence: 99%

miR‐193: A new weapon against cancer

Khordadmehr

Shahbazi

Sadreddini

et al. 2019

Journal Cellular Physiology

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microRNAs (miRNAs) are known as a large group of short noncoding RNAs, which structurally consist of 19–22 nucleotides in length and functionally act as one of the main regulators of gene expression in important biological and physiological contexts like cell growth, apoptosis, proliferation, differentiation, movement (cell motility), and angiogenesis as well as disease formation and progression importantly in cancer cell invasion, migration, and metastasis. Among these notable tiny molecules, many studies recently presented the important role of the miR‐193 family comprising miR‐193a‐3p, miR‐193a‐5p, miR‐193b‐3p, and miR‐193b‐5p in health and disease biological processes by interaction with special targeting and signaling, which mainly contribute as a tumor suppressor. Therefore, in the present paper, we review the functional role of this miRNA family in both health and disease conditions focusing on various tumor developments, diagnoses, prognoses, and treatment.

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Section: Introductionmentioning

confidence: 99%

miR‐193: A new weapon against cancer

Khordadmehr

Shahbazi

Sadreddini

et al. 2019

Journal Cellular Physiology

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“…The oral glucose tolerance test (OGTT) was conducted to diagnose diabetes. After fasting for 12 hours overnight, the blood samples were collected from the tail vein . Following blood collection, the mice were fed with 50% glucose through a gastric tube at a dose of 2 g/kg body weight.…”

Section: Methodsmentioning

confidence: 99%

“…Western blot analysis was performed as previously described . We used primary antibodies against Sirt 1, GRP 78, ATF3, CHOP, Bax, Bcl‐2, cleaved caspase‐9, caspase‐9, cleaved caspase‐3, caspase‐3, and the β‐actin,as well as appropriate secondary antibodies.…”

Section: Methodsmentioning

confidence: 99%

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Overexpression of miR‐22 attenuates oxidative stress injury in diabetic cardiomyopathy via Sirt 1

Tang

Len

Zheng

et al. 2018

Cardiovascular Therapeutics

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“…miRNAs can also actively participate in the pathogenesis of cardiac structural damage, mitochondrial dysfunction, inflammatory response, angiogenic regulation and myocardial electrical remodelling . Arnold et al reported that miR‐29 overexpression in a diabetes model was associated with cardiac structural damage and accompanied by decreased expression of myeloid cell leukaemia 1, a protein that promotes cell survival.…”

Section: Mirnasmentioning

confidence: 99%

Non‐coding RNA involvement in the pathogenesis of diabetic cardiomyopathy

Zhang

et al. 2019

J Cellular Molecular Medi

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In recent years, the incidence of diabetes has been increasing rapidly, which seriously endangers human health. Diabetic cardiomyopathy, an important cardiovascular complication of diabetes, is characterized by myocardial fibrosis, ventricular remodelling and cardiac dysfunction. It has been documented that mitochondrial dysfunction, oxidative stress, inflammatory response, autophagy, apoptosis, diabetic microangiopathy and myocardial fibrosis are implicated in the pathogenesis of diabetic cardiomyopathy. With the development of molecular biology technology, accumulating evidence demonstrates that non‐coding RNAs (ncRNAs) are critically involved in the molecular mechanisms of diabetic cardiomyopathy. In this review, we summarize the pathological roles of three types of ncRNAs (microRNA, long ncRNA and circular RNA) in the progression of diabetic cardiomyopathy, which may provide valuable insights into the pathogenesis of diabetic cardiovascular complications.

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MicroRNA-193-5p modulates angiogenesis through IGF2 in type 2 diabetic cardiomyopathy

Cited by 25 publications

References 24 publications

miR‐193: A new weapon against cancer

miR‐193: A new weapon against cancer

Overexpression of miR‐22 attenuates oxidative stress injury in diabetic cardiomyopathy via Sirt 1

Non‐coding RNA involvement in the pathogenesis of diabetic cardiomyopathy

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