MicroRNA-19a acts as a prognostic marker and promotes prostate cancer progression via inhibiting VPS37A expression

Fu, Fangqiu; Wang, Dan; Kong, Zhe; Zhang, Yalong; Wang, Chenji; Wu, Hai; Yao, Li

doi:10.18632/oncotarget.23026

Cited by 20 publications

(10 citation statements)

References 45 publications

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“…miRs regulate ~60% of all human protein coding genes, indicating that miRs serve important roles in physiological and pathological behavior, including cell proliferation, cycle, apoptosis, metastasis, embryogenesis and differentiation (10). The dysregulation of miRs has been recently reported in different types of malignancies, including OS (11), prostate cancer (12), breast cancer (13) and colorectal cancer (14). Abnormally expressed miRs may serve tumor suppressive roles or oncogenic roles in tumorigenesis and tumor development, which depend on the biological functions of their target genes (15).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1

Guang-hong

Jiang

2018

Mol Med Report

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Aberrantly expressed microRNAs (miRs) are implicated in the regulation of osteosarcoma (OS) onset and development. Therefore, key miRs in OS must be identified to develop promising and effective therapeutic targets for patients with OS. In the present study, reverse transcription‑quantitative polymerase chain reaction analysis revealed that miR‑376a‑3p expression was downregulated in OS tissues and cell lines. Additionally, decreased miR‑376a expression was associated with tumor size and lymph node infiltration. Restoration of miR‑376a expression reduced cell proliferation and invasion of OS. Furthermore, special AT‑rich sequence‑binding protein 1 (SATB1) was identified as a direct target gene of miR‑376a in OS cells. Furthermore, SATB1 was overexpressed in OS tissues and SATB1 overexpression was inversely correlated with the expression level of miR‑376a. In addition, ectopic SATB1 expression counteracted the inhibitory effects of miR‑376a overexpression on the proliferation and invasion of OS cells. All these results identified that reduced miR‑376a expression may be implicated in the mechanism underlying OS progression, suggesting that the miR‑376a/SATB1 axis may be a promising novel target for potential therapeutic methods for the effective treatment of patients with OS.

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Section: Introductionmentioning

confidence: 99%

MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1

Guang-hong

Jiang

2018

Mol Med Report

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“…First of all, for lack of specific data in text for RFS, the relevant HRs and its confidence intervals of Fu et al [17] extracted by the Kaplan–Meier Curves with Engauge Digitizer 9.8 as well as the spreadsheet calculator designed by Tierney et al [33] did not support the significance claimed in the original article. The data were collected by two independent authors (Xiangyu Deng and Kaige Ma) from Fu et al [17] for several times using the methods described above whose accuracy had been proved by many researches [47–49]. The extracted data were always consistent but significantly different from the original articles.…”

Section: Discussionmentioning

confidence: 99%

MiR-19a as a prognostic indicator for cancer patients: a meta-analysis

Peng

Huang

et al. 2019

Bioscience Reports

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MiR-19a was aberrantly expressed in various types of cancers and was observed to be potentially associated with the prognosis of cancer patients. The present analysis aims to elucidate its precise predictive value in various human malignancies. Online electronic searches of PubMed, Web of Science (WOS), Embase in English and VIP, Wanfang, SinoMed, and the China National Knowledge Infrastructure (CNKI) in Chinese up to September 8, 2018 were conducted. As a result, in overall analysis, a significant association was identified between miR-19a levels and OS (HRs = 2.31, CI: 1.11–4.83). The relation of miR-19a expression to OS was further recognized by fixed model within the studies of sample size less than 150 (HRs = 1.68, CI: 1.35–2.08), NOS scores greater than or equal to 8 (HRs = 1.53, CI: 1.13–2.06) or less than 8 (HRs = 1.89, CI: 1.58–2.27), specimen derived from tumor (HRs = 1.73, CI: 1.42–2.12) or blood (HRs = 1.87, CI: 1.46–2.40) and the patients of osteosarcoma (HRs = 7.17, CI: 5.04–10.21). Sensitivity analyses revealed no significant results. The association between miR-19a expression level and DFS was also found to be significant (HRs = 2.03, CI: 1.13–3.66). Correlations between miR-19a levels and clinicopathological features were examined and revealed that lymph node metastasis was significantly associated with miR-19a expression levels (OR = 0.565, CI: 0.346–0.921). Summarily, the over expression of miR-19a was an underlying risk of poor prognosis in many human malignancies, especially in osteosarcoma. Moreover, elevated miR-19a expression was linked to the potential of lymph node metastasis.

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“…MiR-19a is also involved in tumor development by promoting cell proliferation and migration, as well as by reducing apoptosis. For example, Liu et al reported that miR-19a promotes cell proliferation and migration in colorectal cancer cells and accelerates tumor growth in xenograft mice [39]; Fu et al, demonstrated that miR-19a overexpression exerts its oncogenic activity by stimulating cell proliferation, cycle, growth and migration [50]. Finally, Paiva et al, suggested that the development of thyroid cancer derived from miR18a and miR19a altered expression depends primarily on cell-specific proteins [51].…”

Section: Discussionmentioning

confidence: 99%

MiR-19a Overexpression in FTC-133 Cell Line Induces a More De-Differentiated and Aggressive Phenotype

Calabrese¹,

Dolcimascolo²,

Torrisi³

et al. 2018

IJMS

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In recent years, microRNAs (miRNAs) have received increasing attention for their important role in tumor initiation and progression. MiRNAs are a class of endogenous small non-coding RNAs that negatively regulate the expression of several oncogenes or tumor suppressor genes. MiR-19a, a component of the oncogenic miR-17-92 cluster, has been reported to be highly expressed only in anaplastic thyroid cancer, the most undifferentiated, aggressive and lethal form of thyroid neoplasia. In this work, we evaluated the putative contribution of miR-19a in de-differentiation and aggressiveness of thyroid tumors. To this aim, we induced miR-19a expression in the well-differentiated follicular thyroid cancer cell line and evaluated proliferation, apoptosis and gene expression profile of cancer cells. Our results showed that miR-19a overexpression stimulates cell proliferation and alters the expression profile of genes related to thyroid cell differentiation and aggressiveness. These findings not only suggest that miR-19a has a possible involvement in de-differentiation and malignancy, but also that it could represent an important prognostic indicator and a good therapeutic target for the most aggressive thyroid cancer.

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MicroRNA-19a acts as a prognostic marker and promotes prostate cancer progression via inhibiting VPS37A expression

Cited by 20 publications

References 45 publications

MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1

MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1

MiR-19a as a prognostic indicator for cancer patients: a meta-analysis

MiR-19a Overexpression in FTC-133 Cell Line Induces a More De-Differentiated and Aggressive Phenotype

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