2019
DOI: 10.3892/ol.2019.10501
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MicroRNA‑2053 overexpression inhibits the development and progression of hepatocellular carcinoma

Abstract: MicroRNAs (miRNAs) represent a class of small RNAs that participate in the regulation of tumor progression. However, the identification of functional miRNAs in tumors has not been thoroughly elucidated. In the present study we aim to investigate the impact of altered miR-2053 expression in hepatocellular carcinoma (HCC) cells. The results of the present study demonstrated that miR-2053 overexpression inhibited cell proliferation, migration and invasion, and promoted apoptosis in a HCC cell line, while miR-2053… Show more

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Cited by 6 publications
(4 citation statements)
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“…As a class of small non-coding protein RNAs, miRNAs are related to the regulation of many cancers. For example, miR-548b inhibited proliferation and invasion of HCC cells through targeting SP1 [27], and miR-2053 downregulated the PI3K and Wnt/β-catenin signaling pathways to hinder HCC progression [28]. In addition, in terms of radiosensitivity, miR-621 was considered to be a tumor radiosensitizer in HCC [29], and miR-203 could improve the radiosensitivity of HCC via targeting Bmi-1 [30].…”
Section: Discussionmentioning
confidence: 99%
“…As a class of small non-coding protein RNAs, miRNAs are related to the regulation of many cancers. For example, miR-548b inhibited proliferation and invasion of HCC cells through targeting SP1 [27], and miR-2053 downregulated the PI3K and Wnt/β-catenin signaling pathways to hinder HCC progression [28]. In addition, in terms of radiosensitivity, miR-621 was considered to be a tumor radiosensitizer in HCC [29], and miR-203 could improve the radiosensitivity of HCC via targeting Bmi-1 [30].…”
Section: Discussionmentioning
confidence: 99%
“…MicroRNAs (miRNAs) are a type of highly conserved RNAs of 19-25 nucleotides in length, regulating the target gene expression at the transcriptional level [8]. It is known that miRNAs regulate multiple cellular biological processes, such as cell proliferation, migration, and invasion [9,10]. A number of miRNAs have been identified to be important regulators involving in the progress of AS, suggesting the potential role of miRNA in the therapeutic strategy for AS, such as miR-135b-5p, miR-499a-3p, and miR-365 [11,12].…”
Section: Introductionmentioning
confidence: 99%
“…MicroRNAs (miRNAs) are a type of highly conserved RNAs of 19-25 nucleotides in length, regulating the target gene expression at the transcriptional level [7]. It is known that miRNAs regulate multiple cellular biological processes, such as cell proliferation, migration, and invasion [8,9]. A number of miRNAs have been identified to be important regulators involving in the progress of AS, suggesting the potential role of miRNA in the therapeutic strategy for AS, such as miR-135b-5p, miR-499a-3p, and miR-365 [10,11].…”
Section: Introductionmentioning
confidence: 99%