MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen

Tagscherer, Katrin E.; Fassl, Anne; Sinkovic, Tabea; Schecher, Sabrina; Macher-Goeppinger, Stephan; Roth, Wilfried

doi:10.1186/s12935-016-0321-6

Cited by 45 publications

(30 citation statements)

References 73 publications

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“…Among those microRNAs presented in our tables, miR-210 overexpression has been shown to increase ROS production in colorectal cancer cells [37, 38]. The augmented ROS can be attributed to compromised mitochondrial activity as miR-210 inhibits mitochondrial iron-sulfur cluster scaffold homologue and the assembly iron-sulfur cluster [37, 39]. MiR-210 also induces ROS generation under hypoxic condition, leading to a poor prognosis in colorectal cancer [37, 38].…”

Section: Aberrant Microrna Profiles and Ros Levels In Colorectal Cancermentioning

confidence: 99%

“…The augmented ROS can be attributed to compromised mitochondrial activity as miR-210 inhibits mitochondrial iron-sulfur cluster scaffold homologue and the assembly iron-sulfur cluster [37, 39]. MiR-210 also induces ROS generation under hypoxic condition, leading to a poor prognosis in colorectal cancer [37, 38]. Furthermore, Tagscherer et al .…”

Section: Aberrant Microrna Profiles and Ros Levels In Colorectal Cancermentioning

confidence: 99%

“…observed miR-210-induced colorectal cancer apoptosis. However, the roles of elevated ROS and miR-210 levels in the regulation of apoptosis and their biological relevance in colorectal cancer have not be thoroughly elucidated and require further investigation [37]. Additionally, overexpressed miR-141 and miR-200a can modulate oxidative stress by targeting p38a and potentiate tumor growth [28].…”

Section: Aberrant Microrna Profiles and Ros Levels In Colorectal Cancermentioning

confidence: 99%

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Potential roles of microRNAs and ROS in colorectal cancer: diagnostic biomarkers and therapeutic targets

Chuang

Zuo

2017

Oncotarget

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As one of the most commonly diagnosed cancers worldwide, colorectal adenocarcinoma often occurs sporadically in individuals aged 50 or above and there is an increase among younger patients under 50. Routine screenings are recommended for this age group to improve early detection. The multifactorial etiology of colorectal cancer consists of both genetic and epigenetic factors. Recently, studies have shown that the development and progression of colorectal cancer can be attributed to aberrant expression of microRNA. Reactive oxygen species (ROS) that play a key role in cancer cell survival, can also lead to carcinogenesis and cancer exacerbations. Given the rapid accumulating knowledge in the field, an updated review regarding microRNA and ROS in colorectal cancer is necessary. An extensive literature search has been conducted in PubMed/Medline databases to review the roles of microRNAs and ROS in colorectal cancer. Unique microRNA expression in tumor tissue, peripheral blood, and fecal samples from patients with colorectal cancer is outlined. Therapeutic approaches focusing on microRNA and ROS in colorectal cancer treatment is also delineated. This review aims to summarize the newest knowledge on the pathogenesis of colorectal cancer in the hopes of discovering novel diagnostic biomarkers and therapeutic techniques.

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Section: Aberrant Microrna Profiles and Ros Levels In Colorectal Cancermentioning

confidence: 99%

Section: Aberrant Microrna Profiles and Ros Levels In Colorectal Cancermentioning

confidence: 99%

Section: Aberrant Microrna Profiles and Ros Levels In Colorectal Cancermentioning

confidence: 99%

See 1 more Smart Citation

Potential roles of microRNAs and ROS in colorectal cancer: diagnostic biomarkers and therapeutic targets

Chuang

Zuo

2017

Oncotarget

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“…In addition, some miRNAs may function as oncogenes or tumor suppressors in tumor development. Furthermore, a widespread down‐regulation of miRNAs is commonly observed in human cancers, which promotes cellular transformation and tumorigenesis . Recent studies have revealed a role of miRNAs in MM.…”

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confidence: 99%

Identification of miRSNPs associated with the risk of multiple myeloma

et al. 2016

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Multiple myeloma (MM) is a malignancy of plasma cells usually infiltrating the bone marrow, associated with the production of a monoclonal immunoglobulin (M protein) which can be detected in the blood and/or urine. Multiple lines of evidence suggest that genetic factors are involved in MM pathogenesis, and several studies have identified single nucleotide polymorphisms (SNPs) associated with the susceptibility to the disease. SNPs within miRNA-binding sites in target genes (miRSNPs) may alter the strength of miRNA-mRNA interactions, thus deregulating protein expression. MiRSNPs are known to be associated with risk of various types of cancer, but they have never been investigated in MM. We performed an in silico genome-wide search for miRSNPs predicted to alter binding of miRNAs to their target sequences. We selected 12 miRSNPs and tested their association with MM risk. Our study population consisted of 1,832 controls and 2,894 MM cases recruited from seven European countries and Israel in the context of the IMMEnSE (International Multiple Myeloma rESEarch) consortium. In this population two SNPs showed an association with p < 0.05: rs286595 (located in gene MRLP22) and rs14191881 (located in gene TCF19). Results from IMMEnSE were meta-analyzed with data from a previously published genome-wide association study (GWAS). The SNPs rs13409 (located in the 3'UTR of the POU5F1 gene), rs1419881 (TCF19), rs1049633, rs1049623 (both in DDR1) showed significant associations with MM risk. In conclusion, we sought to identify genetic polymorphisms associated with MM risk starting from genome-wide prediction of miRSNPs. For some mirSNPs, we have shown promising associations with MM risk.

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“…miRNAs serve an important function in the regulation of gene expression by interacting with complementary sites in the 3'-untranslated regions (3'-UTRs) of target mRNAs, inducing translational repression or mRNA cleavage (9). Multiple studies have reported that miRNAs regulate a number of physiological and pathological processes, which include cell proliferation, the cell cycle, differentiation, apoptosis, metastasis, angiogenesis and metabolism (10)(11)(12). miRNAs are involved in tumorigenesis and cancer development, with >50% of miRNAs located at cancer-associated genomic regions (13,14).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑539 inhibits colorectal cancer progression by directly targeting SOX4

Zhao

Zhang

2018

Oncol Lett

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Abstract. Colorectal cancer (CRC) is the third most prevalent cancer and the fourth most common cause of cancer-associated mortality in males and females globally. Aberrant expression of microRNA-539 (miR-539) has been reported in multiple types of cancer. However, miR-539 expression, function and underlying mechanisms have not been clearly elucidated in CRC. In the present study, miR-539 expression was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in CRC tissues and cell lines. The effects of miR-539 on CRC cells were further examined in in vitro studies. In addition, the direct targets of miR-539 in CRC were investigated using bioinformatics, luciferase reporter assays, RT-qPCR and western blotting. miR-539 was revealed to be significantly downregulated in CRC cell lines and tissues. Decreased miR-539 expression was associated with lymph node metastasis and tumor-node-metastasis stage in patients with CRC. Functional assays revealed that the rescue of miR-539 expression attenuated CRC cell proliferation and invasion in vitro. Additionally, SRY-box 4 (SOX4) was validated as a direct target gene of miR-539 in CRC. Furthermore, SOX4 was revealed to be upregulated in CRC tissues at the mRNA and protein level. A significant negative correlation between miR-539 and SOX4 mRNA expression levels was observed in CRC tissues. Furthermore, upregulation of SOX4 partially restored the tumor suppressive effects of miR-539 on CRC cell proliferation and invasion. Taken together, this suggests that miR-539 may serve tumor-suppressive functions in CRC during the process of malignant transformation, by directly targeting SOX4. miR-539/SOX4-based targeted therapy may represent a potential novel treatment for patients with CRC.

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MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen

Cited by 45 publications

References 73 publications

Potential roles of microRNAs and ROS in colorectal cancer: diagnostic biomarkers and therapeutic targets

Potential roles of microRNAs and ROS in colorectal cancer: diagnostic biomarkers and therapeutic targets

Identification of miRSNPs associated with the risk of multiple myeloma

MicroRNA‑539 inhibits colorectal cancer progression by directly targeting SOX4

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