MicroRNA-218 inhibits EMT, migration and invasion by targeting SFMBT1 and DCUN1D1 in cervical cancer

Jiang, Zhaojing; Song, Qiancheng; Zeng, Rong; Li, Jing; Li, Jingyu; Lin, Xiaochun; Chen, Xing; Zhang, Jiren; Zheng, Yanfang

doi:10.18632/oncotarget.9850

Cited by 62 publications

(52 citation statements)

References 42 publications

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“…Previous studies have demonstrated that DCUN1D1 is upregulated in squamous cell carcinoma, and promotes non-small cell lung cancer progression and brain metastasis (27,28). Recently, Jiang et al (22) reported that miR-218 inhibited epithelial-mesenchymal transition, migration and invasion by targeting Scm-like with four mbt domains 1 and DCUN1D1 in cervical cancer. However, the regulatory mechanism of DCUN1D1 expression in cervical cancer has remained obscure.…”

Section: Discussionmentioning

confidence: 99%

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MicroRNA‑302 inhibits cell migration and invasion in cervical cancer by targeting DCUN1D1

Jiang

Hou

et al. 2018

Exp Ther Med

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Abstract. MicroRNA serve crucial roles in a variety of human cancer types. The miR-302-367 cluster has been reported to suppress the proliferation of cervical carcinoma cells through the novel target AKT1; however, the molecular mechanism of miR-302 in cervical cancer metastasis remains unclear. The present study aimed to investigate the clinical significance of miR-302-3p expression in cervical cancer, and to examine the regulatory mechanism of miR-302-3p in the malignant phenotypes of cervical cancer cells. The present data indicated that miR-302-3p was significantly downregulated in cervical cancer tissues compared with the level in adjacent non-tumor tissues, and low expression of miR-302-3p was significantly associated with node metastasis, advanced clinical stage, and poor prognosis in patients with cervical cancer. Restoration of miR-302-3p expression caused a significant reduction in cervical cancer cell migration and invasion. Defective in cullin neddylation 1 domain containing 1 (DCUN1D1) was identified as a novel target gene of miR-302-3p, and miR-302-3p negatively regulated the mRNA and protein expression of DCUN1D1 in cervical cancer HeLa cells. Additionally, overexpression of DCUN1D1 rescued the effects of miR-302-3p on the migration and invasion of cervical cancer cells. Furthermore, DCUN1D1 was upregulated in cervical cancer tissues compared with the levels in adjacent tissues, and its high expression was associated with node metastasis, advanced clinical stage, and shorter survival time in patients with cervical cancer. Notably, a negative correlation between miR-302-3p and DCUN1D1 expression in cervical cancer tissues was observed. Taken together, the present study suggests that miR-302-3p serves a suppressive role in cervical cancer metastasis, partly at least, via directly targeting DCUN1D1. Therefore, miR-302-3p/DCUN1D1 may be a potential therapeutic target for cervical cancer treatment.

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Section: Discussionmentioning

confidence: 99%

“…Recently, miR-218 was reported to inhibit cervical cancer cell migration and invasion by targeting DCUN1D1 (22). However, whether DCUN1D1 is also regulated by other miRNA in cervical cancer remains unclear.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑302 inhibits cell migration and invasion in cervical cancer by targeting DCUN1D1

Jiang

Hou

et al. 2018

Exp Ther Med

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“…EMT is tightly regulated by several internal and external stimuli that orchestrate the transition from an epithelial-like to a mesenchymal phenotype (15)(16)(17). EMT facilitates tumor cell invasiveness and metastatic capacity, and is thus a principal mediator of cancer progression and metastasis (18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Upregulation of contactin‑1 expression promotes prostate cancer progression

et al. 2019

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Contactin-1 (CNTN-1) has been reported to serve an oncogenic role in several cancer types. However, detailed mechanisms describing the influence of CNTN-1 in prostate cancer progression have not yet been elucidated. The present study aimed to determine the clinical significance of CNTN-1 expression in prostate cancer progression, and also to investigate the regulatory role of CNTN-1 in the proliferation, migration and invasive ability of prostate cancer cells. The results of the present study indicated that expression levels of CNTN-1 were significantly higher in prostate cancer tissues compared with adjacent normal tissues. Moreover, a high expression level of CNTN-1 was positively correlated with tumor size, stage and metastasis, as well as a poorer prognosis in patients with prostate cancer. Furthermore, CNTN-1-knockdown in prostate cancer cells (using short hairpin RNA) resulted in the significant inhibition of cancer cell proliferation, colony formation, migration and invasiveness. Silencing of CNTN-1 expression also suppressed epithelial-mesenchymal transition in prostate cancer cells via the upregulation of E-cadherin, and the downregulation of N-cadherin and vimentin expression. Inhibition of CNTN-1 expression also reduced the activity of the PI3K/AKT signaling pathway in prostate cancer cells. Thus, it was demonstrated that CNTN-1 expression is upregulated, and plays an oncogenic role, in prostate cancer cells. The results of the current study suggest that CNTN-1 may represent a promising therapeutic target, potentially improving the treatment of patients with prostate cancer.

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“…One of the targets of miR-218 is LAMB3 with roles in cell migration and carcinogenesis of cervical cancer. Another study revealed that the expression of miR-218 can lead to EMT inhibition, migration and invasion by targeting pro-tumorigenic genes such as SFMBT1 and DCUN1D1 [69]. Recently, the expression of miR-218…”

Section: High-risk Hpv Infection Modulates Mirna Expression In Cervicmentioning

confidence: 99%

The Role of miRNAs in Diagnosis, Prognosis and Treatment Prediction in Cervical Cancer

Bălăcescu¹,

Bălăcescu²,

Baldasici³

et al. 2017

Colposcopy and Cervical Pathology

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Cervical cancer represents one of the major problems of health women worldwide, especially in the developing countries. If discovered in its earliest stages, cervical cancer is successfully treatable; however, due to lack of proper implementation of screening programs, the majority of cervical cancer patients are diagnosed in advanced stages, which dramatically influence their outcome. Almost a half of these patients will suffer recurrence or metastasis in the following 2 years after therapy. If there are no immediate prospects in terms of developing new or more effective therapies, identifying new tools for early diagnosis, prognosis and treatment prediction remains a big challenge for cervical cancer. miRNAs have been validated to be key players in cell physiology, alterations in miRNA expression being associated with cancer progression and response to therapy. Cervical cancer studies have showed that alterations of miRNA expression can be identified in tumor tissues, exfoliated cervical cells and patients serum and that their transcription pattern is regulated by the present HPV genotype. Furthermore, miRNAs have been associated with patients response to therapy, therefore suggesting their potential to be used as biomarkers for cervical cancer diagnosis, prognosis and treatment response.

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MicroRNA-218 inhibits EMT, migration and invasion by targeting SFMBT1 and DCUN1D1 in cervical cancer

Cited by 62 publications

References 42 publications

MicroRNA‑302 inhibits cell migration and invasion in cervical cancer by targeting DCUN1D1

MicroRNA‑302 inhibits cell migration and invasion in cervical cancer by targeting DCUN1D1

Upregulation of contactin‑1 expression promotes prostate cancer progression

The Role of miRNAs in Diagnosis, Prognosis and Treatment Prediction in Cervical Cancer

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