MicroRNA-25 expression level is an independent prognostic factor in epithelial ovarian cancer

Wang, Xue E; Meng, Xianhua; Li, H.; Liu, W.; Shen, Shuling; Gao, Zheng

doi:10.1007/s12094-014-1178-6

Cited by 31 publications

(26 citation statements)

References 16 publications

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“…Therefore, it is critical to understand the roles of miRNAs in cancer development and progression, and explore their potential as novel therapeutic targets for the treatment of patients with cancer. Previous studies have implicated miR-25-3p in several types of human cancer (17)(18)(19); however, the roles of miR- 25-3p in OS have yet to be elucidated. The present study aimed to assess the expression of miR-25-3p in OS tissues and cell lines, and explore its biological functions in OS cells in vitro.…”

Section: Upregulation Of Microrna-25-3p Inhibits Proliferation Migramentioning

confidence: 99%

Upregulation of microRNA-25-3p inhibits proliferation, migration and invasion of osteosarcoma cells in vitro by directly targeting SOX4

Zhou

Yue

et al. 2017

Molecular Medicine Reports

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Osteosarcoma (OS) is among the most common primary tumors of bone tissue, and occurs primarily in children and young adults. Despite the development of novel therapeutic approaches, the prognosis of OS remains poor. MicroRNAs (miRNAs) are involved in the development and progression of various types of human cancer and may have potential as novel therapeutic targets for cancer treatment. The present study aimed to investigate the expression and biological functions of miRNA‑25‑3p in OS, and explore the molecular mechanisms underlying its actions. In the present study, miRNA‑25‑3p was detected in OS tissues and cell lines. The functional roles of miRNA‑25‑3p in OS cells were evaluated using a Cell Counting Kit 8 assay and cellular migration and invasion assays. The molecular mechanisms underlying the tumor‑suppressing roles of miRNA‑25‑3p in OS were explored using bioinformatics analysis, luciferase reporter assay, western blotting and the reverse transcription‑quantitative polymerase chain reaction. The expression of miRNA‑25‑3p was revealed to be downregulated in OS tissues and cell lines compared with non‑tumor bone tissues and normal osteoblasts, respectively. miRNA‑25‑3p overexpression was demonstrated to significantly suppress the proliferation, migration and invasion of OS cells in vitro. In addition, sex‑determining region‑related high mobility group box (SOX) 4 was identified as a direct target gene of miRNA‑25‑3p, and was further investigated. Similarly to miRNA‑25‑3p overexpression, SOX4 knockdown was demonstrated to suppress OS cell proliferation, migration and invasion. Furthermore, SOX4 expression was revealed to be significantly upregulated in OS tissues compared with in adjacent non‑tumor bone tissues, and Spearman's correlation analysis indicated a negative correlation between SOX4 mRNA and miRNA‑25‑3p expression levels in OS tissues. The present findings suggested that miRNA‑25‑3p may act as a tumor suppressor by targeting SOX4 expression in bone tissue. Therefore, miRNA‑25‑3p may have potential as a novel therapeutic target for the treatment of patients with OS.

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Section: Upregulation Of Microrna-25-3p Inhibits Proliferation Migramentioning

confidence: 99%

Upregulation of microRNA-25-3p inhibits proliferation, migration and invasion of osteosarcoma cells in vitro by directly targeting SOX4

Zhou

Yue

et al. 2017

Molecular Medicine Reports

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“…Specific miRNA expression and/or levels of expression in particular tissues may predict certain diseases. Thus, these miRNAs can be selected as candidate biomarkers for the diagnosis and prognosis of various tumours [20,22,24]. The expression and function of various miRNAs have been reported in glioma [17,25,26].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-210 regulates cell proliferation and apoptosis by targeting regulator of differentiation 1 in glioblastoma cells

Zhang¹,

Lai²,

Liao³

et al. 2015

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“…Xu et al found that miR-25 promoted migration and invasion of esophageal squamous cell carcinoma cells [16]. In OC, Wang et al reported that miR-25 was increased in OC, and elevated expression of miR-25 was associated with poor prognosis of EOC [11]. Zhang et al also found that miR-25 promoted OC cell proliferation by targeting B cell lymphoma 2-interacting mediator of cell death (Bim) [17].…”

Section: Discussionmentioning

confidence: 99%

“…In OC, miRNAs act as either oncogenes or tumor suppressor [9,10]. MiR-25 has been found to be increased in OC; however, its detailed role remains unclear [11].…”

Section: Introductionmentioning

confidence: 99%

MiR-25 promotes ovarian cancer proliferation and motility by targeting LATS2

et al. 2014

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Ovarian cancer (OC) is a major cancer-related mortality among women. Recent studies suggest that many microRNAs (miRNAs) were dysregulated and involved in tumorigenesis of OC. The present study investigated the role of miR-25 in the development and progression of OC. The expression of miR-25 was increased in OC tissues and cell lines. Inhibition of miR-25 remarkably suppressed proliferation, migration, and invasion of OC cells. Large tumor suppressor 2 (LATS2), a tumor suppressor, was confirmed to be a direct target of miR-25 in OC cells. Moreover, restoration of LATS2 significantly attenuated the oncogenic effects of miR-25. Together, our data suggest an oncogenic role of miR-25 in OC and a potentially novel diagnostic and therapeutic target for OC treatment.

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MicroRNA-25 expression level is an independent prognostic factor in epithelial ovarian cancer

Abstract: The increased expression of miR-25 is closely related to poor prognosis of EOC, indicating that miR-25 may serve as a predictive biomarker for the prognosis of EOC.

Cited by 31 publications

References 16 publications

Upregulation of microRNA-25-3p inhibits proliferation, migration and invasion of osteosarcoma cells in vitro by directly targeting SOX4

Upregulation of microRNA-25-3p inhibits proliferation, migration and invasion of osteosarcoma cells in vitro by directly targeting SOX4

MicroRNA-210 regulates cell proliferation and apoptosis by targeting regulator of differentiation 1 in glioblastoma cells

MiR-25 promotes ovarian cancer proliferation and motility by targeting LATS2

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