MicroRNA-320a inhibits breast cancer metastasis by targeting metadherin

Yu, Juan; Wang, Jigang; Zhang, Lei; Yang, Haiping; Wang, Lei; Ding, Di; Chen, Qi; Yang, Wenlin; Ren, Kehan; Zhou, Danmei; Zou, Qiang; Jin, Yonglong; Liu, Xiuping

doi:10.18632/oncotarget.9572

Cited by 53 publications

(45 citation statements)

References 35 publications

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“…The miRNA has been demonstrated to inhibit breast cancer metastasis and invasion [28, 29] while also sensitizing breast cancer cells to chemotherapy [30, 31]. Additionally, miR-320a has been observed to be an independent prognostic factor where decreased miR-320a expression is correlated with lower survival in invasive breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas

et al. 2016

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Breast cancer is the second-most common cancer and second-leading cause of cancer mortality in American women. The dysregulation of microRNAs (miRNAs) plays a key role in almost all cancers, including breast cancer. We comprehensively analyzed miRNA expression, global gene expression, and patient survival from the Cancer Genomes Atlas (TCGA) to identify clinically relevant miRNAs and their potential gene targets in breast tumors. In our analysis, we found that increased expression of 12 mature miRNAs—hsa-miR-320a, hsa-miR-361-5p, hsa-miR-103a-3p, hsa-miR-21-5p, hsa-miR-374b-5p, hsa-miR-140-3p, hsa-miR-25-3p, hsa-miR-651-5p, hsa-miR-200c-3p, hsa-miR-30a-5p, hsa-miR-30c-5p, and hsa-let-7i-5p —each predicted improved breast cancer survival. Of the 12 miRNAs, miR-320a, miR-361-5p, miR-21-5p, miR-103a-3p were selected for further analysis. By correlating global gene expression with miRNA expression and then employing miRNA target prediction analysis, we suggest that the four miRNAs may exert protective phenotypes by targeting breast oncogenes that contribute to patient survival. We propose that miR-320a targets the survival-associated genes RAD51, RRP1B, and TDG; miR-361-5p targets ARCN1; and miR-21-5p targets MSH2, RMND5A, STAG2, and UBE2D3. The results of our stringent bioinformatics approach for identifying clinically relevant miRNAs and their targets indicate that miR-320a, miR-361-5p, and miR-21-5p may contribute to breast cancer survival.

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Section: Discussionmentioning

confidence: 99%

Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas

et al. 2016

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“…Recent studies indicated miR-320a inhibited gastric cancer cell proliferation by downregulating FoxM1 10 and suppressed cancer metastasis by directly targeting metadherin. 11 It can also inhibit cell proliferation of leukemia 12 and colon cancer. 13 Downregulation of its expression is associated with a poor prognosis of clinical patients with cancer.…”

Section: Introductionmentioning

confidence: 99%

MiR-320a effectively suppresses lung adenocarcinoma cell proliferation and metastasis by regulating STAT3 signals

et al. 2017

Cancer Biology & Therapy

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MicroRNAs play important roles in tumorigenesis of various types of cancers. MiR-320a can inhibits cell proliferation of some cancers, but the biologic roles of miR-320a in lung cancer need to be further studied. Here, we investigated the roles of miR-320a in suppressing the proliferation of lung adenocarcinoma cells. MiR-320a treatment was found to effectively suppress LTEP-a-2 and A549 cell proliferation, and induce more apoptotic cells with irradiation treatment compared with control treatment. Our results also showed that miR-320a, as a novel miRNA, directly regulated signal transducer and activator of transcription 3 (STAT3) and its signals, such as Bcl ¡ 2, Bax, and Caspase 3. The siRNA-inhibited STAT3 levels further proved its roles in regulating STAT3 signals. Moreover, miR-320a treatment effectively suppressed cancer cell growth in mice xenografts compared with controls, and significantly inhibited cell migration in vitro and in vivo. Our findings collectively demonstrated that miR-320a, by directly regulating STAT3 signals, not only suppressed cell proliferation and metastasis, but also enhanced irradiation-induced apoptosis of adenocarcinomia cells.Abbreviations: GFP, green fluorescent protein; HE, hematoxylin-eosin staining; miRNAs, microRNAs; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NSCLC, Non-small cell lung cancer; STAT3, signal transducer and activator of transcription 3

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“…Ectopic expression of miR-205 in MDA-MB-231 cells inhibits cell proliferation, invasion, anchorage independent growth and experimental metastases to the lungs (153). miR-320a acts by suppressing metadherin (MTDH) expression and is down-regulated in BC tissues and cell lines (154). MTDH expression is related to breast cancer progression (155).…”

Section: Further Breast Cancer Metastasis-suppressive Mirsmentioning

confidence: 99%

“…MTDH expression is related to breast cancer progression (155). miR-320a suppresses lung metastases of MDA-MB-231 cells (154).…”

Section: Further Breast Cancer Metastasis-suppressive Mirsmentioning

confidence: 99%

The Role of micro RNAs in Breast Cancer Metastasis: Preclinical Validation and Potential Therapeutic Targets

Weidle

Dickopf

Hintermair

et al. 2018

CGP

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MicroRNA-320a inhibits breast cancer metastasis by targeting metadherin

Cited by 53 publications

References 35 publications

Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas

Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas

MiR-320a effectively suppresses lung adenocarcinoma cell proliferation and metastasis by regulating STAT3 signals

The Role of micro RNAs in Breast Cancer Metastasis: Preclinical Validation and Potential Therapeutic Targets

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