MicroRNA‑409 may function as a tumor suppressor in endometrial carcinoma cells by targeting Smad2

Zhang, Chunhua; Wang, Bo; Wu, Ling

doi:10.3892/mmr.2018.9642

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…The decreased miR-200c blood levels in our cancer patients were described for hepatic cellular cancer tissue, and its potential as a prognostic marker or even as a therapeutic target discussed [ 61 ]. The findings of lower miR-409 are concordant to previous results in EC tissue and BC cell lines compared to healthy tissue [ 62 ] [ 63 ]. MiR-375 was higher among EC patients compared to the BC and the control group.…”

Section: Discussionsupporting

confidence: 90%

Potential of blood-based biomarker approaches in endometrium and breast cancer: a case-control comparison study

Schuhn

Tobar

Gahlawat

et al. 2022

Arch Gynecol Obstet

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Purpose Endometrial carcinoma is the second most common gynecological malignancy. Until today lacking a screening tool. A blood-based biomarker could help address this need. Methods The expression levels of 30 acylcarnitines, 18 amino acids, 6 miRNAs, and 7 DNA methylation sites were measured in blood samples from 331 women (20 EC, 14 benign uterine lesions (benign), 140 breast cancers (BC), 157 controls). Areas under the ROC curves (AUC), sensitivity (sens.) and specificity (spec.) were computed to identify the variables best distinguishing. Results The best top ten markers for the four comparisons (cancer vs. cancer-free; EC vs. BC, EC vs. controls; EC vs. benign), were identified via AUC. Malonylcarnitine distinguished best patients with EC from controls (AUC: 0.827, sens. 80%, spec. 73.1%) or BC (AUC: 0.819, sens. 84.3%, spec. 80%) being most notable. Tryptophan best differentiated benign from EC (AUC: 0.846, sens. 70%, spec. 92.9%). Conclusions The levels of the analyzed blood markers yielded promising results in the detection of EC and warrant further evaluation.

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Section: Discussionsupporting

confidence: 90%

Potential of blood-based biomarker approaches in endometrium and breast cancer: a case-control comparison study

Schuhn

Tobar

Gahlawat

et al. 2022

Arch Gynecol Obstet

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show abstract

“…SMAD2 acts as a downstream effector in the TGF-β signaling pathway and is essential for pattern formation and tissue differentiation (Massague 2012 ; Hata and Chen 2016 ; Granadillo et al 2018 ). The degradation of SMAD2 transcripts mediated by miRNAs contributes to tumorigenesis (Hu et al 2017 ; Zhang et al 2019a , b ; Shi et al 2020 ). More interestingly, SMAD2 has been shown to play a key role in NSCLC.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the circRNA-miRNA-mRNA signaling axis has been implicated in NSCLC development and progression. For instance, the circ-CPA4/let-7/PD-L1 axis regulates NSCLC cell growth and stemness, immune evasion, and drug resistance (Hong et al 2020 ); circFGFR1 promotes anti-PD-1 resistance by sponging miR-381-3p in NSCLC cells (Zhang et al 2019a , b ); and circTP63 facilitates the tumorigenesis and progression of LUSC by regulating the miR-873-3p/FOXM1 signaling (Cheng et al 2019 ). Circular RNA SCAP (circSCAP) is a newly identified circRNA and can promote NSCLC progression by activating p53 signaling through interacting with SF3A3 (Chen et al 2022 ).…”

Section: Introductionmentioning

confidence: 99%

EIF4A3-induced circular RNA SCAP facilitates tumorigenesis and progression of non-small-cell lung cancer via miR-7/SMAD2 signaling

Zhang

2023

Environ Sci Pollut Res

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The eukaryotic translation initiation factor 4A (eIF4A) family determines transcription efficiency by directly binding to precursor RNAs. One member, EIF4A3, modulates the expression of circRNAs. Circular RNA SCAP (circSCAP), a newly found circRNA, has been implicated in atherosclerosis. Yet, how circSCAP regulates cancer development and progression remains understudied. Here, we investigated the function of circSCAP and the molecular mechanism in the tumorigenesis and progression of non-small-cell lung cancer (NSCLC). CircSCAP was upregulated in both NSCLC tissues and cell lines and was mainly located in the cytoplasm. CircSCAP expression was promoted by EIF4A3, which was associated with poor prognosis in patients with NSCLC. CircSCAP sponged miR-7 to upregulate small mothers against decapentaplegic 2 (SMAD2). CircSCAP knockdown undermined cell proliferation, migration, and invasion abilities in NSCLC cell lines (SPCA1 and A549), which was rescued by either inhibiting miR-7 or overexpressing SMAD2. Moreover, circSCAP knockdown upregulated E-cadherin, while downregulating N-cadherin, Vimentin, and MMP9 in SPCA1 and A549 cells, which were abolished by either inhibiting miR-7 or overexpressing SMAD2. Additionally, miR-7 was markedly downregulated, whereas SMAD2 was significantly upregulated in NSCLC tissues. MiR-7 expression was inversely correlated with circSCAP and SMAD2 expression in NSCLC tissues. In conclusion, this study demonstrates that circSCAP is significantly upregulated in NSCLC cell lines and tissues and elucidates that circSCAP facilitates NSCLC progression by sponging miR-7 and upregulating SMAD2. The study provides a novel molecular target for early diagnosis and treatment of NSCLC.

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Platelet-derived growth factor-stimulated pulmonary artery smooth muscle cells regulate pulmonary artery endothelial cell dysfunction through extracellular vesicle miR-409-5p

Heo,

Kang

2023

Biological Chemistry

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Platelet-derived growth factor (PDGF)-induced changes in vascular smooth muscle cells (VSMCs) stimulate vascular remodeling, resulting in vascular diseases such as pulmonary arterial hypertension. VSMCs communicate with endothelial cells through extracellular vesicles (EVs) carrying cargos, including microRNAs. To understand the molecular mechanisms through which PDGF-stimulated pulmonary artery smooth muscle cells (PASMCs) interact with pulmonary artery endothelial cells (PAECs) under pathological conditions, we investigated the crosstalk between PASMCs and PAECs via extracellular vesicle miR-409-5p under PDGF stimulation. miR-409-5p expression was upregulated in PASMCs upon PDGF signaling, and it was released into EVs. The elevated expression of miR-409-5p was transported to PAECs and led to their impaired function, including reduced NO release, which consequentially resulted in enhanced PASMC proliferation. We propose that the positive regulatory loop of PASMC-extracellular vesicle miR-409-5p-PAEC is a potential mechanism underlying the proliferation of PASMCs under PDGF stimulation. Therefore, miR-409-5p may be a novel therapeutic target for the treatment of vascular diseases, including pulmonary arterial hypertension.

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MicroRNA‑409 may function as a tumor suppressor in endometrial carcinoma cells by targeting Smad2

Cited by 6 publications

References 29 publications

Potential of blood-based biomarker approaches in endometrium and breast cancer: a case-control comparison study

Potential of blood-based biomarker approaches in endometrium and breast cancer: a case-control comparison study

EIF4A3-induced circular RNA SCAP facilitates tumorigenesis and progression of non-small-cell lung cancer via miR-7/SMAD2 signaling

Platelet-derived growth factor-stimulated pulmonary artery smooth muscle cells regulate pulmonary artery endothelial cell dysfunction through extracellular vesicle miR-409-5p

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