MicroRNA-425-5p modulates osteoporosis by targeting annexin A2

Chen, Guanghua; Huang, Guizhi; Han, Lin; Wu, Xinyou; Tan, Xiaoyan; Chen, Zhoutao

doi:10.1186/s12979-021-00256-7

Cited by 7 publications

(2 citation statements)

References 30 publications

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“…These findings suggest that miR-425-5p promotes value-addition in BMECs by specifically targeting and regulating TOB2. Previous investigations have also shown that miR-425-5p regulates cellular value-addition through its targeting of AFF4 and ANXA2 [23,50].…”

Section: Discussionmentioning

confidence: 89%

miR-425-5p Regulates Proliferation of Bovine Mammary Epithelial Cells by Targeting TOB2

Li,

Chen,

et al. 2024

Genes

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In recent years, rising temperatures have caused heat stress (HS), which has had a significant impact on livestock production and growth, presenting considerable challenges to the agricultural industry. Research has shown that miR-425-5p regulates cellular proliferation in organisms. However, the specific role of miR-425-5p in bovine mammary epithelial cells (BMECs) remains to be determined. The aim of this study was to investigate the potential of miR-425-5p in alleviating the HS-induced proliferation stagnation in BMECs. The results showed that the expression of miR-425-5p significantly decreased when BMEC were exposed to HS. However, the overexpression of miR-425-5p effectively alleviated the inhibitory effect of HS on BMEC proliferation. Furthermore, RNA sequencing analysis revealed 753 differentially expressed genes (DEGs), comprising 361 upregulated and 392 downregulated genes. Some of these genes were associated with proliferation and thermogenesis through enrichment analyses. Further experimentation revealed that TOB2, which acts as a target gene of miR-425-5p, is involved in the regulatory mechanism of BMEC proliferation. In summary, this study suggests that miR-425-5p can promote the proliferation of BMECs by regulating TOB2. The miR-425-5p/TOB2 axis may represent a potential pathway through which miR-425-5p ameliorates the proliferation stagnation of BMECs induced by HS.

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Section: Discussionmentioning

confidence: 89%

miR-425-5p Regulates Proliferation of Bovine Mammary Epithelial Cells by Targeting TOB2

Li,

Chen,

et al. 2024

Genes

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“…ANXA2 is a target of Mir-425-5p and is involved in TNF-induced apoptosis, proliferation and differentiation of MSC cells. It was concluded that Mir-425-5P could enhance osteoporosis in mice ( 94 ). The above studies indicate that the mechanism of miRNA action on osteoporosis still needs further study.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic perspectives of exosomes in glucocorticoid-induced osteoarthrosis

Cheng

et al. 2022

Front. Surg.

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Exosomes are widely involved in a variety of physiological and pathological processes. These important roles are also hidden in the physiological processes related to bone. Chondrocytes, osteoblasts, synovial fibroblasts, and bone marrow mesenchymal stem cells produce and secrete exosomes, thereby affecting the biology process of target cells. Furthermore, in the primary pathogenesis of osteoarthrosis induced by steroid hormones, mainly involve glucocorticoid (GC), the exosomes have also widely participated. Therefore, exosomes may also play an important role in glucocorticoid-induced osteoarthrosis and serve as a promising treatment for early intervention of osteoarthrosis in addition to playing a regulatory role in malignant tumors. This review summarizes the previous results on this direction, systematically combs the role and therapeutic potential of exosomes in GC-induced osteoarthrosis, discusses the potential role of exosomes in the treatment and prevention of GC-induced osteoarthrosis, and reveals the current challenges we confronted.

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