2015
DOI: 10.1016/j.biochi.2015.04.011
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MicroRNA-494 inhibition protects nucleus pulposus cells from TNF-α-induced apoptosis by targeting JunD

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Cited by 63 publications
(52 citation statements)
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“…For instance, miR-27a is highly expressed in degenerative human NP cells and induces their apoptosis by blocking phosphoinositide 3-kinase/AKT signaling [37], while downregulation of miR-210 may promote Fas-mediated NP cell apoptosis in human IDD [38]. Moreover, our findings are also consistent with the results from the work by Wang et al [39], which reported that miR-494 inhibition protects NP cells from TNF-α-induced apoptosis by targeting JunD.…”
Section: Discussionsupporting
confidence: 91%
“…For instance, miR-27a is highly expressed in degenerative human NP cells and induces their apoptosis by blocking phosphoinositide 3-kinase/AKT signaling [37], while downregulation of miR-210 may promote Fas-mediated NP cell apoptosis in human IDD [38]. Moreover, our findings are also consistent with the results from the work by Wang et al [39], which reported that miR-494 inhibition protects NP cells from TNF-α-induced apoptosis by targeting JunD.…”
Section: Discussionsupporting
confidence: 91%
“…The rate of apoptosis was measured as previously described. 23 Cells (1 × 10 6 ) were stained with annexin V-PE and 7-AAD (BD Biosciences). manufacturer's instructions.…”
Section: Flow Cytometrymentioning
confidence: 99%
“…MicroRNAs (miRNAs) are a class of endogenously expressed, small non-coding RNAs, which can negatively modulate gene expression by targeting mRNAs for translational repression and/or cleavage [108][109][110]. It has been demonstrated that miR-494 is highly expressed in degenerative human NP tissues, and knockout of miR-494 protects human NP cells from apoptosis induced by TNF-α through up-regulation of JunD, which is mediated via cytochrome C apoptotic signaling [111].…”
Section: Tnf-α Induces Apoptosis Of Ivd Cellsmentioning
confidence: 99%