MicroRNA‑589 serves as a tumor suppressor microRNA through directly targeting metastasis‑associated protein 2 in breast cancer

Chen, Jun

doi:10.3892/ol.2019.10548

Cited by 9 publications

(6 citation statements)

References 24 publications

(35 reference statements)

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“…More importantly, the function of miRNA in BC has been revealed by various studies. For example, miRNA-589 functions as a tumor inhibitor via directly targeting metastasis-associated protein 2 (MTA2) in BC 27 . MiR-29b-3p promotes the proliferation and migration of MDA-MB-231 cells (TNBC cells) via down-regulating TRAF3 28 .…”

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA LRRC75A-AS1 facilitates triple negative breast cancer cell proliferation and invasion via functioning as a ceRNA to modulate BAALC

Jia

et al. 2020

Cell Death Dis

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As a common female malignancy, triple-negative breast cancer (TNBC) is the most serious subtype in breast cancer (BC). BAALC binder of MAP3K1 and KLF4 (BAALC) is a common oncogene in acute myelocytic leukemia (AML). We sought to explore the role of BAALC in TNBC. In this study, BAALC was significantly upregulated in TNBC tissues and cells. Then, the results of functional assays disclosed that BAALC facilitated cell proliferation, invasion, and epithelial-mesenchymal transition (EMT) processes, but repressed cell apoptosis in TNBC. Next, miR-380-3p was identified as the upstream of BAALC in TNBC cells. Moreover, LRRC75A-AS1 (also named small nucleolar RNA host gene 29: SNHG29) was verified to act as the sponge of miR-380-3p to elevate BAALC expression in TNBC. Besides, LRRC75A-AS1 could negatively regulate miR-380-3p but positively regulate BAALC expression. Finally, rescue assays elucidated that LRRC75A-AS1 facilitated cell proliferation, invasion, and EMT processes in TNBC by targeting miR-380-3p/BAALC pathway. Taken together, our study revealed a novel ceRNA network of LRRC75A-AS1/miR-380-3p/ BAALC in accelerating TNBC development, indicating new promising targets for TNBC treatment.

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Section: Discussionmentioning

confidence: 99%

Long non-coding RNA LRRC75A-AS1 facilitates triple negative breast cancer cell proliferation and invasion via functioning as a ceRNA to modulate BAALC

Jia

et al. 2020

Cell Death Dis

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“…10,11 For example, miR-589 served as a tumor suppressor in TNBC by targeting the metastasis-associated protein 2. 12 Recent study showed that the overexpression of miR-29b-3p promoted the progression of TNBC via downregulating TNF Receptor Associated Factor 3 (TRAF3) and activating nuclear factor-kappa B signaling. 13 Interestingly, an increasing body of evidence demonstrated the tumor suppressive potential of miR-331-3p in multiple cancers.…”

Section: Introductionmentioning

confidence: 99%

miR-331-3p Suppresses Cell Proliferation in TNBC Cells by Downregulating NRP2

Zhao

Zhang

Tao

et al. 2020

Technol Cancer Res Treat

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Purpose: Triple-negative breast cancer is characterized by fast progression with high possible for metastasis and poor survival. Dysfunction of microRNAs plays an important role in the initiation and progression of cancer. Our previous microRNA-seq data indicated the downregulation of miR-331-3p in triple-negative breast cancer tissues compared with that of the noncancer tissues. However, the function of miR-331-3p in triple-negative breast cancer remains largely unknown. Herein, the involvement of miR-331-3p in triple-negative breast cancer was investigated and the therapeutic potential of miR-331-3p was also explored. Methods: Real-time quantitative polymerase chain reaction was performed to detect the expression of miR-331-3p in triplenegative breast cancer tissues and cell lines. The cell proliferation was determined by the cell counting kit-8 assay. Apoptosis of triple-negative breast cancer cells was examined by annexin V/propidium iodide staining. miRDB database was used to predict the potential targets of miR-331-3p. Western blot was performed to examine the expression of the target protein. Results: miR-331-3p was significantly downregulated in triple-negative breast cancer tissues and cell line. Lower miR-331-3p expression was significantly correlated with the tumor size, TNM stage, and lymph node metastasis of patients with triple-negative breast cancer. Functional experiments showed that the overexpression of miR-331-3p inhibited the proliferation and increased apoptosis of triple-negative breast cancer cells. Neuropilin-2 was identified as a target of miR-331-3p, which harbored binding site of miR-331-3p in its 3 0 -untranslated region. Overexpression of miR-331-3p decreased the messenger RNA and protein levels of neuropilin-2 in triple-negative breast cancer cells. Restoration of neuropilin-2 partially reversed the inhibitory effects of miR-331-3p on the proliferation of triple-negative breast cancer cells. Conclusions: Our results demonstrated the novel function of miR-331-3p/ neuropilin-2 signaling in regulating the malignant behaviors of triple-negative breast cancer cells, which suggested miR-331-3p as a potential target for the treatment of triple-negative breast cancer.

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“…Given the regulatory role of the miR-589-5p/HDAC5 pathway in proliferation, migration, invasion, and tumorigenicity in NSCLC cells, this pathway was suggested as a new prognostic biomarker and therapeutic target against NSCLC (Liu et al, 2017). It was also found that the expression of miR-589-5p down-regulated in other cancers such as prostate (Ji et al, 2019) and triple-negative breast cancer (TNBC) (Chu, 2019). These results suggest that miR-589-5p through oncogenic or tumor-suppressive functions may be a potential biomarker in OSCC and different cancers.…”

Section: Discussionmentioning

confidence: 89%

Differential Expression of miR-589-5p, miR-569 and c-Fos gene in Oral Squamous Cell Carcinoma

Mohammadi

Mohammadpour

Jamshidian

2022

Egyptian Academic Journal of Biological Sciences. C, Physiology

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Background: Oral squamous cell carcinoma (OSCC) is the most prevalent cancer among the Head and Neck Squamous cell carcinomas (HNSCC) group. Most OSCC cases are diagnosed at advanced stages, resulting in poor survival and a high mortality rate. This study aimed to investigate the changes in expression levels of miR-589-5p, miR-569, and c-Fos (as a target gene) in tumor and adjacent normal tissues from OSCC patients. Also, the association between the c-Fos gene expression and several clinicopathological factors was evaluated. Methods: c-Fos was predicted as a potential target gene of miR-589-5p and miR-569 using the Mirwalk and miRDB bioinformatic algorithms. The expression levels of these miRNAs and c-Fos target gene in 30 OSCC tissues compared to their adjacent-normal tissue samples were analyzed by quantitative real-time PCR. In addition, the potential diagnostic values of miR-589-5p and miR-569 in OSCC as risk factors of carcinogenesis were assessed by ROC curve analysis. Results: c-Fos expression was significantly increased, while miR-589-5p and miR-569 gene expressions were decreased in tumor tissues compared to normal tissues. The increased c-Fos expression was also significantly correlated with tumor necrosis (p=0.034). We found that downregulation of miR-589-5p and miR-569 was negatively correlated with overexpression of the c-Fos target gene. The area under the curve (AUC) of mir-589-5p and mir-569 was 0.865 and 0.591, respectively. Conclusion: miR-589-5p may serve as a potent diagnostic and prognostic biomarkers for OSCC patients and be a potential approach to early diagnosis or prognosis of OSCC in the future. c-Fos overexpression may have a role in OSCC progression and necrosis.

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MicroRNA‑589 serves as a tumor suppressor microRNA through directly targeting metastasis‑associated protein 2 in breast cancer

Cited by 9 publications

References 24 publications

Long non-coding RNA LRRC75A-AS1 facilitates triple negative breast cancer cell proliferation and invasion via functioning as a ceRNA to modulate BAALC

Long non-coding RNA LRRC75A-AS1 facilitates triple negative breast cancer cell proliferation and invasion via functioning as a ceRNA to modulate BAALC

miR-331-3p Suppresses Cell Proliferation in TNBC Cells by Downregulating NRP2

Differential Expression of miR-589-5p, miR-569 and c-Fos gene in Oral Squamous Cell Carcinoma

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