MicroRNA-650 targets ING4 to promote gastric cancer tumorigenicity

Zhang, Xueli; Zhu, WeiYing; Zhang, Jifa; Huo, ShouJun; Zhou, Lianming; Gu, Zhen; Zhang, Min

doi:10.1016/j.bbrc.2010.04.005

Cited by 98 publications

(93 citation statements)

References 25 publications

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“…Potential target genes of miR-650 were predicted using bioinformatics analysis. Among these putative targets, ING4 was identified as a direct of miR-650 in gastric cancer (21) and hepatocellular carcinoma (26), and also CDK1, ING4, EBF3 in chronic lymphocytic leukemia (23), CSR1 in prostate cancer (27). In this study, we selected LATS2 for further confirmation (Fig.…”

Section: Lats2 Is a Direct Target Of Mir-650 In Vitromentioning

confidence: 84%

“…Discussion miR-650 has been reported to be abnormally expressed in many types of malignancies. For example, Zhang et al (21) found that miR-650 expression was increased in gastric cancer tissues and cell lines. High miR-650 expression was significantly correlated with lymphatic and distant metastasis of gastric cancer (21).…”

Section: Lats2 Is Associated With the Effects Of Mir-650 In Nsclc Cellsmentioning

confidence: 99%

“…miR-650 has been studied in several types of human cancer (21)(22)(23). In this work, we measured miR-650 expression in NSCLC tissues and cell lines.…”

Section: Introductionmentioning

confidence: 99%

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microRNA-605 promotes cell proliferation, migration and invasion in non-small cell lung cancer by directly targeting LATS2

Zhuang

Wang

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Lung cancer is the most common cause of cancerassociated mortality for men and women worldwide. An increasing number of studies have reported that the abnormal expression of microRNAs contributes to the pathogenesis of the majority of human cancer types, including non-small cell lung cancer (NSCLC). The present study aimed to measure microRNA-650 (miR-650) expression in NSCLC and evaluate its function in NSCLC cells. Reverse transcription-quantitative polymerase chain reaction was used to determine miR-650 expression in NSCLC tissue samples and cell lines. Assays for cell proliferation, migration and invasion were performed to investigate the roles of miR-650 on NSCLC progression. Furthermore, the mechanisms underlying the effects of miR-650 on NSCLC cell growth and metastasis were determined. In the current study, miR-650 was demonstrated to be highly expressed in NSCLC tissue samples and cell lines. Inhibition of expression of miR-650 suppressed NSCLC cell proliferation, migration and invasion in vitro. Additionally, large tumor suppressor kinase 2 (LATS2) was identified as a direct target gene of miR-650 in NSCLC. LATS2 was revealed to be significantly downregulated in NSCLC tissues and was negatively correlated with miR-650 expression. Notably, LATS2 re-expression decreased NSCLC cell proliferation, migration and invasion; similar to the effects induced by miR-650 underexpression. In conclusion, the results of the current study suggest that miR-650 may serve as an oncogene by direct targeting LATS2 in NSCLC formation and progression.

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Section: Lats2 Is a Direct Target Of Mir-650 In Vitromentioning

confidence: 84%

Section: Lats2 Is Associated With the Effects Of Mir-650 In Nsclc Cellsmentioning

confidence: 99%

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microRNA-605 promotes cell proliferation, migration and invasion in non-small cell lung cancer by directly targeting LATS2

Zhuang

Wang

et al. 2017

Experimental and Therapeutic Medicine

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“…It has been shown that immunoglobulin gene rearrangement upregulates the expression of miR-650 in chronic lymphocytic leukemia (Mraz et al, 2012). Inhibitor of Growth 4 (ING4) is a tumor suppressor and a target of miR-650 both in gastric cancer and hepatocellular carcinoma (Zhang et al, 2010;Zeng et al, 2013) . N-myc downstream-regulated gene 2 (NDRG2) is also a direct target of miR-650 in colorectal cancer cells (Feng et al, 2011).…”

Section: Mir-650mentioning

confidence: 99%

miR-421, miR-155 and miR-650: Emerging Trends of Regulation of Cancer and Apoptosis

Farooqı

Qureshi²,

Çoşkunpınar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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It is becoming progressively more understandable that between transcription and translation there lies another versatile regulator that quantitatively controls the expression of mRNAs. Identification of miRNAs as key regulators of wide ranging signaling cascades and modulators of different cell-type and context dependent activities attracted basic and clinical scientists to study modes and mechanisms in details. In line with this approach overwhelmingly increasing in vivo and in vitro studies are deepening our understanding regarding miR-421, mir-155 and miR-650 mediated regulation of cellular activities. We also attempt to provide an overview of long non coding RNAs.

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“…The dysregulated miRNAs and their confirmed targets are listed in Supplementary Table 1 (Volinia et al, 2006;Zhang et al, 2007aZhang et al, , 2008Zhang et al, , 2009Zhang et al, , 2010Kim do et al, 2007;Chan et al, 2008;Choy et al, 2008;Petrocca et al, 2008;Ando et al, 2009;Bandres et al, 2009;Du et al, 2009;Guo et al, 2009;Katada et al, 2009;Kim et al, 2009;Liu et al, 2009;Saito et al, 2009;Takagi et al, 2009;Chen et al, 2010;Fassi Fehri et al, 2010;Gao et al, 2010;Hashimoto et al, 2010;Jiang et al, 2010;Lai et al, 2010;Matsushima et al, 2010;Motoyama et al, 2008Motoyama et al, , 2010Shen et al, 2010;Shinozaki et al, 2010;Tsujiura et al, 2010;Tsukamoto et al, 2010;Ueda et al, 2010;Wan et al, 2010;Wu et al, 2010a;Xia et al, 2008;Xiao et al, 2009;Zhu et al, 2010).…”

Section: Dysregulated Mirnas In Gastric Cancermentioning

confidence: 99%