MicroRNA‑761 is downregulated in colorectal cancer and regulates tumor progression by targeting Rab3D

Ren, Yupeng; Shi, Gang; Jiang, Peng; Meng, Qingkai

doi:10.3892/etm.2018.7126

Cited by 9 publications

(12 citation statements)

References 20 publications

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“…Notably, the mechanisms responsible for the tumor-suppressing action on miR-761 upregulation in OS cells were also thoroughly analyzed in this study. miR-761 is downregulated in colorectal [20][21][22] and ovarian 23 cancers. The downregulation of miR-761 is related with the tumor size, tumor grade, and tumor stage in patients with colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…The downregulation of miR-761 is related with the tumor size, tumor grade, and tumor stage in patients with colorectal cancer. 20,21 Patients with colorectal cancer having low miR-761 expression show worse 5-year overall survival compared to patients with high miR-761 expression. 20 On the contrary, miR-761 is upregulated in non-small cell lung cancer, 24,38 breast cancer 25 and hepatocellular carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…20,21 Patients with colorectal cancer having low miR-761 expression show worse 5-year overall survival compared to patients with high miR-761 expression. 20 On the contrary, miR-761 is upregulated in non-small cell lung cancer, 24,38 breast cancer 25 and hepatocellular carcinoma. 39 However, there has been no study to investigate the expression level and clinical significance of miR-761 in OS.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, restoring miR-761 expression decreases cell proliferation, cell cycle, colony formation, migration, and invasion in colorectal cancer. [20][21][22] Moreover, it has been reported that upregulation of miR-761 increases the chemosensitivity of colorectal cancer cells to 5-Fluorouracil. 21 Shi and Zhang have reported that restoring miR-761 expression attenuated the proliferation and invasion of ovarian cancer cells.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, miR-761 has been reported to be downregulated in many types of human cancer, and has been revealed to play important roles in the genesis and progression of cancer. [20][21][22][23][24][25] However, the biological roles of miR-761 in OS and its underlying mechanism remains largely unknown. In the present study, we detected miR-761 expression in OS and investigated the regulatory effects of miR-761 overexpression on OS progression.…”

Section: Introductionmentioning

confidence: 99%

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<p>MicroRNA-761 targets FGFR1 to suppress the malignancy of osteosarcoma by deactivating PI3K/Akt pathway</p>

Wang

et al. 2019

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Purpose: has been reported to be deregulated in many types of human cancers and play important roles in cancer genesis and progression. However, the biological roles of miR-761 in osteosarcoma (OS) and the underlying mechanisms remain largely unknown. Methods: The expression of miR-761 in OS tissues and cell lines was analyzed using RT-qPCR. A series of gain-of-function tests were performed, and status of malignancy was evaluated on basis of proliferation, migration, invasion, and apoptosis using different assays to determine the regulatory roles of miR-761 in OS cells in vivo and in vitro. Notably, the mechanisms underlying the action of miR-761 in the pathogenesis of OS were investigated using bioinformatic analysis, luciferase reporter assay, RT-qPCR and Western blotting. Results: The results showed that miR-761 expression was decreased in OS tissues and cell lines and is closely correlated with clinical stage and distant metastasis in OS patients. Patients with OS having low miR-761 expression showed worse prognosis compared to OS patients with high miR-761 expression. Restoring the miR-761 expression level decreased OS cell proliferation, migration, and invasion in vitro; promoted cell apoptosis in vitro; and impaired tumor growth in vivo. In addition, fibroblast growth factor receptor 1 (FGFR1) was found as a direct target gene of miR-761 in OS cells. Furthermore, silencing FGFR1 expression stimulated the tumor-suppressing roles of miR-761 upregulation in OS cells, whereas the activity of miR-761 overexpression in OS cells was abolished by the restoration of FGFR1 expression. Moreover, restoration of miR-761 expression deactivated the PI3K/ Akt pathway in vitro and in vivo. Conclusion: These results suggest that miR-761 plays anti-cancer roles in OS by directly targeting FGFR1 and deactivating the PI3K/Akt pathway. The newly identified miR-761/ FGFR1/PI3K/Akt pathway partially illustrates the mechanism of OS pathogenesis and presents a novel candidate therapeutic target for antitumor therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

<p>MicroRNA-761 targets FGFR1 to suppress the malignancy of osteosarcoma by deactivating PI3K/Akt pathway</p>

Wang

et al. 2019

OTT

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Rab3 proteins and cancer: Exit strategies

Raffaniello

2021

J of Cellular Biochemistry

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Rab proteins are GTPases involved in all stages of vesicular transport and membrane fusion in mammalian cells. Individual Rab proteins localize to specific cellular organelles and regulate a specific membrane trafficking pathway. Recent studies suggest an important role for Rab proteins in cancer. Rab3 isoforms (Rab3A, Rab3B, Rab3C, and Rab3D) are expressed almost exclusively in neurons and secretory cells. In this review, the role of Rab3 isoforms in a variety of tumor types is discussed. Of the four Rab3 isoforms, Rab3D has been studied most extensively in cancer cells and this isoform appears to play an oncogenic role in breast, colon, esophageal, skin, and brain tumors. Overexpression of Rab3A and Rab3C was observed in gliomas and colon cancers, respectively. Increased expression of the Rab3 isoforms is related to increased proliferation, migration, and invasiveness. Moreover, high Rab3 isoform levels are often associated with decreased survival and advanced pathological stage in clinical samples. Rab3 isoform-dependent activation of the AKT pathway has been observed in several studies. Although the effects of Rab3 isoforms on cancer cell growth and function have been examined in many tumor types, a number of important questions remain. Are the Rab3-positive vesicles in cancer cells actually secretory in nature? If so, are the How to cite this article: Raffaniello RD. Rab3 proteins and cancer: exit strategies.

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Long Non-coding RNA LOXL1-AS1 Facilitates Colorectal Cancer Progression via Regulating miR-1224-5p/miR-761/HK2 Axis

et al. 2022

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MicroRNA‑761 is downregulated in colorectal cancer and regulates tumor progression by targeting Rab3D

Cited by 9 publications

References 20 publications

<p>MicroRNA-761 targets FGFR1 to suppress the malignancy of osteosarcoma by deactivating PI3K/Akt pathway</p>

<p>MicroRNA-761 targets FGFR1 to suppress the malignancy of osteosarcoma by deactivating PI3K/Akt pathway</p>

Rab3 proteins and cancer: Exit strategies

Long Non-coding RNA LOXL1-AS1 Facilitates Colorectal Cancer Progression via Regulating miR-1224-5p/miR-761/HK2 Axis

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