MicroRNA-Based Fingerprinting of Cervical Lesions and Cancer

Pisarska, Justyna; Baldy-Chudzik, Katarzyna

doi:10.3390/jcm9113668

Cited by 20 publications

(28 citation statements)

References 169 publications

(226 reference statements)

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“…For example, mounting evidence suggests that miRNAs show specific expression profiles at various stages of cervical pathology. However, there is currently no established algorithm that would incorporate the alterations in miRNA expressions to CC screening, as discussed by Pisarska et al [ 56 ]. In the same review, the authors comprehensibly described the relation of miRNA profiles with HPV infection.…”

Section: Cervical Precancerous Lesionsmentioning

confidence: 99%

New Trends in the Detection of Gynecological Precancerous Lesions and Early-Stage Cancers

Holcakova

Bartošík

Anton

et al. 2021

Cancers

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The prevention and early diagnostics of precancerous stages are key aspects of contemporary oncology. In cervical cancer, well-organized screening and vaccination programs, especially in developed countries, are responsible for the dramatic decline of invasive cancer incidence and mortality. Cytological screening has a long and successful history, and the ongoing implementation of HPV triage with increased sensitivity can further decrease mortality. On the other hand, endometrial and ovarian cancers are characterized by a poor accessibility to specimen collection, which represents a major complication for early diagnostics. Therefore, despite relatively promising data from evaluating the combined effects of genetic variants, population screening does not exist, and the implementation of new biomarkers is, thus, necessary. The introduction of various circulating biomarkers is of potential interest due to the considerable heterogeneity of cancer, as highlighted in this review, which focuses exclusively on the most common tumors of the genital tract, namely, cervical, endometrial, and ovarian cancers. However, it is clearly shown that these malignancies represent different entities that evolve in different ways, and it is therefore necessary to use different methods for their diagnosis and treatment.

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Section: Cervical Precancerous Lesionsmentioning

confidence: 99%

New Trends in the Detection of Gynecological Precancerous Lesions and Early-Stage Cancers

Holcakova

Bartošík

Anton

et al. 2021

Cancers

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“…MicroRNA (miRNA) are involved in carcinogenesis and response to viral infections. Human papillomaviruses induce aberrant expression of many cellular miRNAs, this dysregulation could be used as a marker in early diagnosis of HR-HPV infection, CIN and cervical cancer [38] . Aberrant expression of lncRNAs (transcripts) has been used as a key factor in cervical tumorigenic process [39] .…”

Section: Introductionmentioning

confidence: 99%

In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review

Carrero

Callejas

Mosquera

2021

Translational Oncology

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Highlights Neoplasia of the cervix is one of the most frequent in women. Immunological impairment in cervical intraepithelial neoplasia and cancer have been reported. In-situ expression of cytokines and leukocytes during the cervical neoplasia occurs. Some of these cytokines can prevent or induce the progression of the neoplasm. Possible role in therapeutics of cervical cancer by cytokine manipulations need to be evaluated.

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“…MicroRNAs (miRNAs) are a class of endogenous non-coding RNAs that regulate gene expression by mediating post-transcriptional silencing ( 16 , 17 ). MiRNAs are widely involved in cell proliferation, cell differentiation, immune responses and other processes, and increasing evidence shows that miRNAs are important regulatory factors in disease progression ( 18 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

The Circ_0001367/miR-545-3p/LUZP1 Axis Regulates Cell Proliferation, Migration and Invasion in Glioma Cells

et al. 2021

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Glioma is the most common primary intracranial malignant tumour in adults. It has a high incidence and poses a serious threat to human health. Circular RNA is a hotspot of cancer research. In this study, we aimed to explore the role of circ_0001367 in gliomagenesis and the underlying mechanism. First, qRT-PCR was conducted, which showed that circ_0001367 level was downregulated in glioma tissues and cells. Next, gain-of-function and loss-of-function assays were performed, which indicated that circ_0001367 inhibited the proliferation, migration and invasion of glioma cells. Subsequent bioinformatics analysis, dual-luciferase reporter assays, RNA immunoprecipitation assays and cell function assays demonstrated that circ_0001367 inhibited the proliferation, migration and invasion of glioma cells by absorbing miR-545-3p and thereby regulating the expression of leucine zipper protein (LUZP1). Finally, an in vivo experiment was conducted, which demonstrated that circ_0001367 inhibited glioma growth in vivo by modulating miR-545-3p and LUZP1. Taken together, the results of this study demonstrate that the circ_0001367/miR-545-3p/LUZP1 axis may be a novel target for glioma therapy.

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MicroRNA-Based Fingerprinting of Cervical Lesions and Cancer

Cited by 20 publications

References 169 publications

New Trends in the Detection of Gynecological Precancerous Lesions and Early-Stage Cancers

New Trends in the Detection of Gynecological Precancerous Lesions and Early-Stage Cancers

In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review

The Circ_0001367/miR-545-3p/LUZP1 Axis Regulates Cell Proliferation, Migration and Invasion in Glioma Cells

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