MicroRNA profiling of follicular lymphoma identifies microRNAs related to cell proliferation and tumor response

Wang, Weixin; Corrigan-Cummins, Meghan; Hudson, Justin; Marić, Irina; Šimáková, Olga; Neelapu, Sattva S.; Kwak, Larry W.; Janik, John E.; Gause, Barry L.; Jaffe, Elaine S.; Calvo, Katherine R.

doi:10.3324/haematol.2011.048132

Cited by 103 publications

(82 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This cluster is widely expressed in healthy tissues and is important for the regulation of the immune and hematopoietic systems and lung development (Lu et al, 2007;Ventura et al, 2008;Xiao et al, 2008). However, it is situated in a region that is commonly amplified and, therefore, is usually over-expressed in many kinds of tumor types, such as lymphomas and cancers of the lung, breast, follicular lymphoma, chronic myeloid leukemia, osteosarcoma, and also cervical cancer (Hayashita et al, 2005;Venturini et al, 2007;Huang et al, 2012;Kang et al, 2012;Li et al, 2012;Wang et al, 2012). Our study showed miR-20a is definitely up-regulated in the impaired tissue with a median of 6.92, up-regulated expression of miR-20a have relationship with LNM, increased tumor sizes, advanced stage, and advanced histological grade of cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

Aberrant Expression of miR-20a and miR-203 in Cervical Cancer

Song¹,

Yao²,

Chen³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Aberrant Expression of miR-20a and miR-203 in Cervical Cancer

Song¹,

Yao²,

Chen³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…miR-374a has diverse biological functions in different tumor types. miR-374a even exhibits contrast regulation in different cancer types, including upregulation in most cancer types (7,(15)(16)(17)(18) and downregulation in earlystage non-small cell lung cancer (4). miR-374a was markedly upregulated in the primary breast cancer tumor samples, and the upregulation promoted epithelial-mesenchymal transition and metastasis in vitro and in vivo (7), suggesting an important role of miR-374a in breast cancer tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, miR-302b inhibited cell proliferation by inducing apoptosis and suppressing the invasion in esophageal squamous cell carcinoma (14). miRNA profiling has shown that microRNA-374a (miR-374a) is overexpressed in many types of cancer, such as head and neck squamous cell carcinoma, follicular lymphoma, osteosarcoma and bladder urothelial carcinoma (15)(16)(17)(18). In breast cancer, miR-374a was markedly upregulated in primary tumor samples from patients with distant metastases and was considered to be associated with poor metastasis-free survival (7).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-374a promotes esophageal cancer cell proliferation via Axin2 suppression

et al. 2015

View full text Add to dashboard Cite

Abstract. is involved in the progress of various types of cancer, and may indicate a poor prognosis. However, its role in esophageal cancer remains to be determined. In the present study, the role of miR-374a in esophageal cancers and cancer cell growth was examined using miR-374a overexpression and underexpression models. The results showed that miR-374a was markedly increased in esophageal cancer cell lines and tumor samples from patients with esophageal cancer. In esophageal cancer Eca109 cells, the ectopic overexpression of miR-374a promoted cell growth. Additionally, cell growth was reduced by miR-374a inhibition. The mechanisms underlying the promotive role were examined and it was found that miR-374a significantly decreased the expression and transcription activity of axis inhibition protein 2 (Axin2). Axin2, a tumor suppressor, exhibited a marked inhibitory effect on Eca109 cell growth. The results identified a new role of miR-374a in esophageal cancer involving Axin2 suppression.

show abstract

“…116 The most widely studied pro-angiogenic factor is VEGF, and miRNA-mediated control over angiogenesis, specifically by modulating VEGF transcripts, has been demonstrated. [117][118][119][120][121] While there are many pro-and anti-angiogenic miRNAs, each member of the miRNA-17-92 cluster (miR-17, -18a, -19a, -19b, -20a and -92a), has been shown to have anti-angiogenic effects on endothelial cell sprouting in vitro and inhibition of these miRNAs increased endothelial sprouting. 122 This effect can also be seen in vivo in a mouse lung cancer model where systemic blockade of the miR-17-92 cluster promoted tumor neovascularization.…”

Section: Microrna Regulation Of Angiogenesismentioning

confidence: 99%

MicroRNAs, immune cells and pregnancy

et al. 2014

View full text Add to dashboard Cite

MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs that are expressed in many cell types, where they regulate the expression of complementary RNAs, thus modulating the stability and translation of mRNAs. miRNAs are predicted to regulate the expression of ,50% of all protein coding genes in mammals. Therefore, they participate in virtually all cellular processes investigated so far. Altered miRNAs expressions are associated with both physiological (pregnancy) and pathological processes (cancer). As the dynamic maternal-fetal interface plays a critical role in the maintenance of successful pregnancy, it is not surprising that the miRNAs that are unique to reproductive tissues are abundantly expressed. Research in this field has demonstrated the presence and dysregulation of a distinct set of pregnancy-associated miRNAs; however, most studies have centered on localizing various miRNAs in reproductive microdomains associated with normal or complicated pregnancies. Although several independent miRNA regulatory mechanisms associated with endometrial receptivity, immune cells, angiogenesis and placental development have been studied, miRNA-mediated regulation of pregnancy remains poorly understood. This review provides a summary of the current data on miRNA regulation as well as functional profiles of miRNAs that are found in the uterus, in immune cells associated with maternal tolerance to the fetus, and those involved in angiogenesis and placental development.

show abstract

MicroRNA profiling of follicular lymphoma identifies microRNAs related to cell proliferation and tumor response

Cited by 103 publications

References 50 publications

Aberrant Expression of miR-20a and miR-203 in Cervical Cancer

Aberrant Expression of miR-20a and miR-203 in Cervical Cancer

MicroRNA-374a promotes esophageal cancer cell proliferation via Axin2 suppression

MicroRNAs, immune cells and pregnancy

Contact Info

Product

Resources

About