MicroRNAs 301a and 93 Biomarkers for Endometrial Cancer

Ahmed, Basim S.; Aljebori, Hussain A.; Al-Sudani, Israa Mahdi

doi:10.5958/0976-5506.2019.00382.6

Cited by 1 publication

(2 citation statements)

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“…47 Chen and colleagues observed that furin induces proliferation and metastasis of ovarian cancer through stimulation of signal transducer activator transduction 3. 48,49 Moreover, in vitro and in vivo studies revealed that overexpression of furin was correlated with the risk of cancer development. 50,51 Moreover, furin activity is increased in both atypical endometrial hyperplasia and endometriosis.…”

Section: Furin and Tumor Progressionmentioning

confidence: 99%

“…In vitro study, included ovarian cancer cell lines demonstrated that furin was highly expressed 47 suggesting that furin could be a biomarker of ovarian carcinoma 47 . Chen and colleagues observed that furin induces proliferation and metastasis of ovarian cancer through stimulation of signal transducer activator transduction 3 48,49 . Moreover, in vitro and in vivo studies revealed that overexpression of furin was correlated with the risk of cancer development 50,51 …”

Section: Furin and Tumor Progressionmentioning

confidence: 99%

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The possible role furin and furin inhibitors in endometrial adenocarcinoma: A narrative review

Al‐kuraishy,

Al‐Maiahy,

Al‐Gareeb

et al. 2023

Cancer Reports

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BackgroundEndometrial adenocarcinoma (EAC) is a malignant tumor of the endometrium. EAC is the most common female malignancy following the menopause period. About 40% of patients with EAC are linked with obesity and interrelated with hypertension, diabetes mellitus, and high circulating estrogen levels. Proprotein convertase (PC) furin was involved in the progression of EAC.Recent findingsFurin is a protease enzyme belonging to the subtilisin PC family called PC subtilisin/kexin type 3 that converts precursor proteins to biologically active forms and products. Aberrant activation of furin promotes abnormal cell proliferation and the development of cancer. Furin promotes angiogenesis, malignant cell proliferation, and tissue invasion by malignant cells through its pro‐metastatic and oncogenic activities. Furin activity is correlated with the malignant proliferation of EAC. Higher expression of furin may increase the development of EAC through overexpression of pro‐renin receptors and disintegrin and metalloprotease 17 (ADAM17). As well, inflammatory signaling in EAC promotes the expression of furin with further propagation of malignant transformation.ConclusionFurin is associated with the development and progression of EAC through the induction of proliferation, invasion, and metastasis of malignant cells of EAC. Furin induces ontogenesis in EAC through activation expression of ADAM17, pro‐renin receptor, CD109, and TGF‐β. As well, EAC‐mediated inflammation promotes the expression of furin with further propagation of neoplastic growth and invasion.

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