MicroRNAs and their role in the malignant transformation of oral leukoplakia: a scoping review

Niklander, Sven; Guerra, Danae; Contreras, F G Maria; González‐Arriagada, Wilfredo Alejandro; Marin, Celia

doi:10.4317/medoral.24975

Cited by 7 publications

(5 citation statements)

References 34 publications

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“…The study of miRNA holds promise. Different systematic reviews have also concluded that they are potential biomarkers for OSCC and OPMDs [ 11 , 72 , 73 ]. The main issue is, as with many of the other markers, is that apart from mir-21, which was assessed by two studies [ 47 , 48 ], the salivary expression of all other miRNAs, has been analyzed by single studies.…”

Section: Discussionmentioning

confidence: 99%

“…Saliva is probably the most attractive secretion for the finding of biomarkers for OSCC and OPMDs, as its collection is easy, non-invasive, fast, and cost-effective. Thus, different studies have explored the possibility of using salivary factors as biomarkers for the development and progression of OSCC and OPMDs [ 9 , 10 , 11 ]. The aim of this study was to perform an exploratory systematic review about the different salivary molecules that have been assessed as possible biomarkers for the diagnosis of OSCC.…”

Section: Introductionmentioning

confidence: 99%

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Salivary Biomarkers for Oral Cancer Detection: An Exploratory Systematic Review

Bastías,

Maturana,

Marín

et al. 2024

IJMS

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Different efforts have been made to find better and less invasive methods for the diagnosis and prediction of oral cancer, such as the study of saliva as a source of biomarkers. The aim of this study was to perform a scoping review about salivary molecules that have been assessed as possible biomarkers for the diagnosis of oral squamous cell carcinoma (OSCC). A search was conducted using EBSCO, PubMed (MEDLINE), Scopus, and Web of Science. The research question was as follows: which molecules present in saliva have utility to be used as biomarkers for the early detection of oral cancer? Sixty-two studies were included. Over 100 molecules were assessed. Most of the markers were oriented towards the early diagnosis of OSCC and were classified based on their ability for detecting OSCC and oral potentially malignant disorders (OPMDs), OSCC outcome prediction, and the prediction of the malignant transformation of OPMDs. TNF-α, IL-1β, IL-6 IL-8, LDH, and MMP-9 were the most studied, with almost all studies reporting high sensitivity and specificity values. TNF-α, IL-1β, IL-6 IL-8, LDH, and MMP-9 are the most promising salivary biomarkers. However, more studies with larger cohorts are needed before translating the use of these biomarkers to clinical settings.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Salivary Biomarkers for Oral Cancer Detection: An Exploratory Systematic Review

Bastías,

Maturana,

Marín

et al. 2024

IJMS

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“…It is worth noting that the differentially expressed miRNAs in OLK are identified to associate with its malignant transformation [ 63 – 66 ]. In the latest scoping review, the authors have included fifteen articles for analysis and identified 21 differentially expressed miRNAs in OLK [ 67 ]. To be specific, 6 miRNAs (miR-21, miR-181b, miR-184, miR-345, miR-146a and miR-208-3p) that were categories as oncogenic, 5 miRNAs (miR-31*, miR-3065-5p, miR-129-2-3p, miR-204-5p and miR-375) that were classified as tumor suppressors and 10 miRNAs (miR-138, miR-639, miR-27a-3p, miR-15b, miR-485-5p, miR-200c, miR-19a, miR-424, miR-205 and miR-21) that were related to epithelial–mesenchymal transition, invasion and migration [ 67 ].…”

Section: The Evs-borne Cargo Are Changed By Cs Exposurementioning

confidence: 99%

“…In the latest scoping review, the authors have included fifteen articles for analysis and identified 21 differentially expressed miRNAs in OLK [ 67 ]. To be specific, 6 miRNAs (miR-21, miR-181b, miR-184, miR-345, miR-146a and miR-208-3p) that were categories as oncogenic, 5 miRNAs (miR-31*, miR-3065-5p, miR-129-2-3p, miR-204-5p and miR-375) that were classified as tumor suppressors and 10 miRNAs (miR-138, miR-639, miR-27a-3p, miR-15b, miR-485-5p, miR-200c, miR-19a, miR-424, miR-205 and miR-21) that were related to epithelial–mesenchymal transition, invasion and migration [ 67 ]. Among these miRNAs, the authors concluded that miR-21, miR-345, miR-181b, miR-31* might be potential markers of malignant transformation of OLK.…”

Section: The Evs-borne Cargo Are Changed By Cs Exposurementioning

confidence: 99%

The potential roles of cigarette smoke-induced extracellular vesicles in oral leukoplakia

et al. 2023

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Background The onset of oral leukoplakia (OLK), the most common oral lesion with a high risk of malignant transformation, is closely associated with the exposure of cigarette smoke. Cigarette smoke is a complicated mixture of more than 4500 different chemicals including various oxidants and free radical, which contributes to the onset of immune and inflammatory response or even carcinogenesis. Recent studies have proved that the exposure of cigarette smoke leads to the onset and aggravation of many diseases via significantly changed the production and components of extracellular vesicles. The extracellular vesicles are membrane-enclosed nanosized particles secreted by diverse cells and involved in cell–cell communication because of their ability to deliver a number of bioactive molecules including proteins, lipids, DNAs and RNAs. Getting insight into the mechanisms of extracellular vesicles in regulating OLK upon cigarette smoke stimulation contributes to unravel the pathophysiology of OLK in-depth. However, evidence done on the role of extracellular vesicles in cigarette smoke-induced OLK is still in its infancy. Materials and methods Relevant literatures on cigarette smoke, oral leukoplakia and extracellular vesicles were searched in PubMed database. Conclusions In this review, we summarize the recent findings about the function of extracellular vesicles in the pathogenesis of cigarette smoke-induced diseases, and to infer their potential utilizations as diagnostic biomarkers, prognostic evaluation, and therapeutic targets of OLK in the future.

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“…miRNA-375 was shown to be downregulated in OSCC and progressive oral leukoplakia compared to non-progressive lesions, indicating that it functions as a tumor suppressor by decreasing SLC7A11 expression during oral carcinogenesis [12]. Specific miRNAs can cause cancer cells to undergo ferroptosis by decreasing SLC7A11 expression [13].…”

Section: Role Of Mirnas In Oral Carcinogenesismentioning

confidence: 99%

A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinoma

Kavitha

Jayachandran

Aishwarya³

et al. 2022

Egypt J Med Hum Genet

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Background Micro-RNAs (miRNAs) have been reported as an emerging biomarker in many cancer types. They are used as diagnostic and prognostic biomarkers and could be considered therapeutic targets in treating the same. Main body Studies have proven that miRNAs play an essential role in molecular cancer pathophysiology, including oral squamous cell carcinoma. Distinct expression profiles of different miRNAs have been demonstrated in oral squamous cell carcinoma. Among the miRNAs, the miR-31 has strong potential as a unique biomarker in head and neck squamous cell carcinoma, and the increased expression was correlated to a poor clinical outcome with a likely contribution to oral carcinogenesis. Short conclusion The recent research on different aspects of miR-31 as a biomarker and also its potential application in the development of therapy for oral squamous cell carcinoma has been focused in this review. Graphical abstract

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MicroRNAs and their role in the malignant transformation of oral leukoplakia: a scoping review

Cited by 7 publications

References 34 publications

Salivary Biomarkers for Oral Cancer Detection: An Exploratory Systematic Review

Salivary Biomarkers for Oral Cancer Detection: An Exploratory Systematic Review

The potential roles of cigarette smoke-induced extracellular vesicles in oral leukoplakia

A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinoma

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