MicroRNAs and Their Therapeutic Potential for Human Diseases: MicroRNAs, miR-143 and -145, Function as Anti-oncomirs and the Application of Chemically Modified miR-143 as an Anti-cancer Drug

Kitade, Yukio; Akao, Yukihiro

doi:10.1254/jphs.10r12fm

Cited by 96 publications

(65 citation statements)

References 22 publications

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“…The downregulation of miR-143 in lung cancer was also been reported [13,19] and be verified by a systematic meta-analysis [20]. The decreasing of miR-143 was thought to be the activation of nuclease and chemically modified miR-143 duplex leads to greater activity and increased resistance to nuclease, which may be used as a candidate for an RNA medicine [21].…”

Section: Discussionmentioning

confidence: 64%

Targeting PKCε by miR‐143 regulates cell apoptosis in lung cancer

2013

FEBS Letters

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a b s t r a c tNon-small cell lung cancer (NSCLC) is one of the most common causes for lung cancer and cancer-related death. The imbalance between cell proliferation and apoptosis was suggested to play an important role in cancer pathogenesis and PKCe is one of the widely recognized targets. Here, we demonstrate that miR-143 is aberrantly downregulated in NSCLC tissue and negatively correlates with expression of PKCe. We show that miR-143 specifically targets the 3 0 -UTR of PKCe and regulates its expression. Treatment with miR-143 inhibitor mimics cell proliferation and apoptosis imbalance in NSCLC, while inhibition of PKCe can reverse it. Our findings suggest that targeting PKCe overexpression in NSCLC should be beneficial for lung cancer therapy.

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Section: Discussionmentioning

confidence: 64%

Targeting PKCε by miR‐143 regulates cell apoptosis in lung cancer

2013

FEBS Letters

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“…These small non-coding single-stranded RNAs regulate gene expression at the post-transcriptional level through imperfect base pairing with the 3Ј-UTR, 5Ј-UTR, or coding regions of the target messenger RNAs (6,7). They regulate the biology of cancer cells, including their chemosensitivity (8,9).…”

mentioning

confidence: 99%

The Overexpression of Hypomethylated miR-663 Induces Chemotherapy Resistance in Human Breast Cancer Cells by Targeting Heparin Sulfate Proteoglycan 2 (HSPG2)

Li²,

Cui

et al. 2013

Journal of Biological Chemistry

110

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Background: miR-663 is related to chemosensitivity in human breast cancer cells. Results: Overexpression of miR-663 was associated with chemoresistance and accompanied by down-regulation of HSPG2. Conclusion: Overexpression of hypomethylated miR-663 induces chemoresistance in breast cancer cells by down-regulating HSPG2. Significance: Learning how miR-663 regulates chemoresistance may provide a potential target for the miRNA-based approach of breast cancer therapy.

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“…miR-143 overexpression in HBx-transfected cells significantly promotes cell migration with no substantial effect on cell proliferation or apoptosis [34]. Invasive capacity of these cells is robustly inhibited by cotransfection of antisense oligonucleotides with miR-143.…”

Section: Roles Of Mirnas In Virus-induced Hccmentioning

confidence: 98%

The role and clinical implications of microRNAs in hepatocellular carcinoma

Zhao

Yang

et al. 2012

Sci. China Life Sci.

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Hepatocellular carcinoma (HCC) is common and one of the most aggressive of all human cancers. Recent studies have indicated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Several miRNAs are involved in hepatitis B or hepatitis C virus replication and virus-induced changes, whereas others participate in multiple intracellular signaling pathways that modulate apoptosis, cell cycle checkpoints, and growth-factor-stimulated responses. When disturbed, these pathways appear to result in malignant transformation and ultimately HCC development. Recently, miRNAs circulating in the blood have acted as possible early diagnostic markers for HCC. These miRNA also could serve as indicators with respect to drug efficacy and be prognostic in HCC patients. Such biomarkers would assist stratification of HCC patients and help direct personalized therapy. Here, we summarize recent advances regarding the role of miRNAs in HCC development and progression. Our expectation is that these and ongoing studies will contribute to the understanding of the multiple roles of these small noncoding RNAs in liver tumorigenesis.

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MicroRNAs and Their Therapeutic Potential for Human Diseases: MicroRNAs, miR-143 and -145, Function as Anti-oncomirs and the Application of Chemically Modified miR-143 as an Anti-cancer Drug

Cited by 96 publications

References 22 publications

Targeting PKCε by miR‐143 regulates cell apoptosis in lung cancer

Targeting PKCε by miR‐143 regulates cell apoptosis in lung cancer

The Overexpression of Hypomethylated miR-663 Induces Chemotherapy Resistance in Human Breast Cancer Cells by Targeting Heparin Sulfate Proteoglycan 2 (HSPG2)

The role and clinical implications of microRNAs in hepatocellular carcinoma

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