MicroRNAs as biomarkers for psychiatric disorders with a focus on autism spectrum disorder: Current progress in genetic association studies, expression profiling, and translational research

Hu, Yubin; Ehli, Erik A.; Boomsma, Dorret I.

doi:10.1002/aur.1789

Cited by 41 publications

(33 citation statements)

References 107 publications

(199 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MiRNAs are single-stranded, non-coding RNA molecules that belong to a family of 18-25 nucleotides-long small non-coding RNAs. Their biogenesis in mammals is a step process that involves multiple enzyme (for a detailed review [73]) and they have two key roles in the regulation of messenger RNA (mRNA): they act by inducing either degradation or translational silencing of the mRNA they target, but in certain instances, miRNAs may activate translation or even act at the level of transcription by binding to specific gene promoters [74,75].…”

Section: Micrornas (Mirnas)mentioning

confidence: 99%

Blood biomarkers and treatment response in major depression

Mora

Zonca

Riva

et al. 2018

Expert Review of Molecular Diagnostics

View full text Add to dashboard Cite

Millions of people worldwide suffer from depression, but despite advances in pharmacological therapies, many patients do not experience symptomatic remission or treatment response, even after treatments with several medications. As such, there is an urgent need to identify biomarkers that can not only predict the treatment response but also allow a rational selection of optimal therapy for each patient. Areas covered: This review examines the recent findings, coming from different 'omic sciences,' in human blood-based biomarkers associated with antidepressant treatment response with particular attention on genetic/epigenetic and biochemical biomarkers. Specific emphasis will be placed on key molecules related to neuroplasticity and inflammation because of their involvement in the pathophysiology of depression and antidepressant response. Expert commentary: Biomarker identification is still an ongoing work. Indeed, to date, no biomarkers have sufficiently proven specificity, sensitivity, and reproducibility to be used in the clinical setting. However, 'omic' approaches hold great promise in identifying multiple features for predicting antidepressant response, making a personalized treatment strategy possible for each patient, and thereby assist with quick and efficacious responsiveness. It is thus necessary that future studies take an integrative approach that includes clinical assessment, environment influences, and molecular and biological biomarkers.

show abstract

Section: Micrornas (Mirnas)mentioning

confidence: 99%

Blood biomarkers and treatment response in major depression

Mora

Zonca

Riva

et al. 2018

Expert Review of Molecular Diagnostics

View full text Add to dashboard Cite

show abstract

“…The development of potential biomarkers of immune dysregulation and their correlation with phenotypic variability should increase the possibility of preselecting patients with a greater potential for improvement with immunomodulatory intervention. In-DOI: 10.1159/000492225 flammatory markers, including miRNA targets, appear to have potential for the development of individualized treatment strategies in the future [3, [243][244][245][246][247] (Fig. 1).…”

Section: Discussionmentioning

confidence: 99%

Immunological Dysfunction in Autism Spectrum Disorder: A Potential Target for Therapy

Marchezan

Santos

Deckmann

et al. 2018

Neuroimmunomodulation

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with an unknown etiology and currently few effective therapies. Immune system alterations have being demonstrated in ASD, both in humans and via animal models; immune imbalance thus arises as a possible pathway for drug intervention. In this review, the studies were classified into 2 major groups: (1) clinical research whose authors classify therapies with primary anti-inflammatory and immunomodulatory actions, making use of: sulforaphane, celecoxib, lenalidomide, pentoxifylline, spironolactone, flavonoid luteolin, corticosteroids, oral immunoglobulin, intravenous immunoglobulin, cell therapy, dialyzable lymphocyte extracts, minocycline, and pioglitazone; and (2) other ASD therapies already used or currently under study whose initial characteristics were neither anti-inflammatory nor immunomodulatory initially, but displayed a capacity for immunomodulation throughout the treatment: risperidone, vitamin D, omega-3, Ginkgo biloba, L-carnosine, N-acetylcysteine, and microbiome restoration. These studies used various data acquisition methodologies. Questions arose such the need for randomized and placebo-controlled studies with greater numbers of participants as well as the use of biomarkers to refine the treatment of autistic subjects.

show abstract

“…Despite intensive ongoing research directed at neurophysiological cues, at present, there are no biomarkers covering the full spectrum of ASD. One major problem is that there is a growing consensus that there are many entries into the autistic spectrum (Leblond et al, 2014) and as a consequence of that it would probably be difficult to find one single biomarker of autism (El-Ansary, Bjorklund, Chirumbolo, & Alnakhli, 2017;Freedman & Foxe, 2017;Hu, Ehli, & Boomsma, 2017). Freedman and Foxe (2017) have presented potential biomarkers, having shown consistent deficits of saccades in autism.…”

Section: Discussionmentioning

confidence: 99%

Parent–infant interactions looking for instances of volitional social gaze versus reflexive gaze – an observational study

Sivberg

Jakobsson

Lundqvist

2017

Early Child Development and Care

View full text Add to dashboard Cite

Very early precursors of disrupted social behaviours are significant to understanding the possibility of mitigating or changing behaviours through interventions. Spontaneous play situations between infant and parent in two groups of infants aged 8.5-9 months were observed. First, a large number of videos were analysed to develop an observational schedule of play behaviour. Second, 135 videos were used in the comparison of atypical (AT; n = 23) and typically developed (TD; n = 22) infants. Frequency and duration of infants' orientation towards the parent's eye zone was significantly higher among TD infants than AT, indicating a stronger social gaze behaviour. Both groups were as competent at screening the surroundings, grabbing, and looking at toys. Finding may indicate an equal competence at reacting to reflexive stimuli. The quality of gaze behaviour provides important information for child healthcare professionals and parents when deciding whether to start supportive intervention or diagnostic investigation. ARTICLE HISTORY

show abstract

MicroRNAs as biomarkers for psychiatric disorders with a focus on autism spectrum disorder: Current progress in genetic association studies, expression profiling, and translational research

Cited by 41 publications

References 107 publications

Blood biomarkers and treatment response in major depression

Blood biomarkers and treatment response in major depression

Immunological Dysfunction in Autism Spectrum Disorder: A Potential Target for Therapy

Parent–infant interactions looking for instances of volitional social gaze versus reflexive gaze – an observational study

Contact Info

Product

Resources

About