MicroRNAs as CNS Drug Targets

Genevieve, David

doi:10.1002/ddr.21336

Cited by 5 publications

(4 citation statements)

References 63 publications

(63 reference statements)

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“…Nano injections of RNAi in dendritic-derived exosomes allowed delivery to the brain without invoking immune response. These fi ndings were confi rmed when Gurwitz et al showed that siRNAs can be delivered across the blood brain barrier in a mouse model using systemic injections of exosomes , (Gurwitz, 2016).…”

Section: Exosome-based Hematologic Malignanciestherapeuticsmentioning

confidence: 82%

The central roles of exosomes in hematological malignancies: A new frontier review

Xia¹,

Li²,

Yang³

et al. 2018

Biosci. Biotech. Res. Comm

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Exosomes, which are 30-to 120-nm vesicles, are released by most types of cells, including tumor cells. In hematological malignancies, exosome-mediated expulsion of a number of key proteins and micro RNAs, resulting in infl uence of major tumor-related pathways. Emerging evidence suggests that the component secreted by exosomescan promote tumor survival,angiogenesis and metastasis, and also mediate tumor microenvironment induced drug resistance and immune escape. Furthermore, exosomes contain a great variety of bioactive molecules and are emerging as rich reservoirs of hematological tumor-specifi c biomarkers for the detection and therapeutics.This comprehensive review highlights the advancements in understanding of the pathogenesis of exosomes secretion and the consequence onhematological malignancies development. Full knowledge of the contribution of exosomes to the potential medical application ofdiagnosis and treatment will depend on the ingenuity of future investigators and their insight into biological processes.

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Section: Exosome-based Hematologic Malignanciestherapeuticsmentioning

confidence: 82%

The central roles of exosomes in hematological malignancies: A new frontier review

Xia¹,

Li²,

Yang³

et al. 2018

Biosci. Biotech. Res. Comm

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“…Additionally, some microRNAs regulate expression and/or function of Cx for several types of cancer ( Calderon and Retamal, 2016 ). These observations suggest that iPSC will have to be engineered to express and transfer not only selected microRNA with antitumor effects but also inhibitors of specific pro-tumorigenic microRNAs (anti-miRs) ( Gurwitz, 2016 ).…”

Section: The Use Of Gap Junctional Shuttling For Glioblastoma Therapymentioning

confidence: 99%

The Microvascular Gap Junction Channel: A Route to Deliver MicroRNAs for Neurological Disease Treatment

Thüringer

Solary

Garrido

2017

Front. Mol. Neurosci.

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Brain microvascular endothelial cells (BMECs) separate the peripheral blood from the brain. These cells, which are surrounded by basal lamina, pericytes and glial cells, are highly interconnected through tight and gap junctions. Their permeability properties restrict the transfer of potentially useful therapeutic agents. In such a hermetic system, the gap junctional exchange of small molecules between cerebral endothelial and non-endothelial cells is crucial for maintaining tissue homeostasis. MicroRNA were shown to cross gap junction channels, thereby modulating gene expression and function of the recipient cell. It was also shown that, when altered, BMEC could be regenerated by endothelial cells derived from pluripotent stem cells. Here, we discuss the transfer of microRNA through gap junctions between BMEC, the regeneration of BMEC from induced pluripotent stem cells that could be engineered to express specific microRNA, and how such an innovative approach could benefit to the treatment of glioblastoma and other neurological diseases.

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“…Exosomes are small membranous vesicles secreted by diverse cell types including neurons and have the ability to cross the BBB [31]. Exogenously prepared exosomes containing mi-RNA have the potential as candidate CNS therapeutics [32]. Furthermore, peptide derived from rabies virus glycoprotein (RVG) carrying antiviral siRNA successfully delivered to brain and provided protection against fatal viral encephalitis in mice [33].…”

Section: The Rapeutic Potential Of Mi-rna In Psychiatric Diseasesmentioning

confidence: 99%

Potential Use of Micro-Rnas as Biomarkers and Therapeutic Purposes in Psychiatric Disorders

Chatterjee¹

2017

TBSND

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There is an increasing need of suitable biomarkers for the diagnosis and management of many psychiatric disorders. In recent time, micro-RNAs have shown substantial potential to become the circulatory biomarkers for a number of diseases. In this small review at attempt has been made to acknowledge recent developments in identifying of potential circulatory micro-RNA biomarkers in the diagnosis of some psychiatric disorders. We have also discussed the potential use of micro-RNA for future therapeutic purposes of such diseases.

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MicroRNAs as CNS Drug Targets

Cited by 5 publications

References 63 publications

The central roles of exosomes in hematological malignancies: A new frontier review

The central roles of exosomes in hematological malignancies: A new frontier review

The Microvascular Gap Junction Channel: A Route to Deliver MicroRNAs for Neurological Disease Treatment

Potential Use of Micro-Rnas as Biomarkers and Therapeutic Purposes in Psychiatric Disorders

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