MicroRNAs as diagnostic and prognostic biomarkers in colorectal cancer

Yi, Rui; Yao, Li; Wang, Fei-Liang; Miao, Gang; Qi, Ruomei; Zhao, Yanyang

doi:10.4251/wjgo.v8.i4.330

Cited by 39 publications

(34 citation statements)

References 98 publications

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“…Extensive research effort has been conducted recently to investigate the potential of using miRNAs as biomarkers for diagnosis, tumor stage as well as for predicting patients’ outcome [48,49,50]. MiRNAs present unique features such as high tissue specificity, good sensitivity and stability.…”

Section: Colorectal Cancer and Mirnamentioning

confidence: 99%

The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer

et al. 2016

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Colorectal cancer is the third most common cancer in the world and considered to be one of the most diet-related types of cancer. Extensive research has been conducted but still the link between diet and colorectal cancer is complex. Recent studies have highlight microRNAs (miRNAs) as key players in cancer-related pathways in the context of dietary modulation. MicroRNAs are involved in most biological processes related to tumor development and progression; therefore, it is of great interest to understand the underlying mechanisms by which dietary patterns and components influence the expression of these powerful molecules in colorectal cancer. In this review, we discuss relevant dietary patterns in terms of miRNAs modulation in colorectal cancer, as well as bioactive dietary components able to modify gene expression through changes in miRNA expression. Furthermore, we emphasize on protective components such as resveratrol, curcumin, quercetin, α-mangostin, omega-3 fatty acids, vitamin D and dietary fiber, with a focus on the molecular mechanisms in the context of prevention and even treatment. In addition, several bioactive dietary components that have the ability to re-sensitize treatment resistant cells are described.

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Section: Colorectal Cancer and Mirnamentioning

confidence: 99%

The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer

et al. 2016

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“…MicroRNAs are a kind of short and single stranded RNAs which can suppress target genes by targeting the 3′‐untranslated regions (3′‐UTR) of mRNAs (Muhammad et al, ). miRNAs can control a lot of important cell processes such as cell proliferation, apoptosis, cell cycle arrest, and invasion (Shea et al, ; Yi et al, ). Recently, microRNAs (miRNAs) have been recognized as significant markers in various cancers (Berindan‐Neagoe & Calin, ; Gu et al, ; Sun & Lai, ).…”

Section: Introductionmentioning

confidence: 99%

H19 promotes non‐small‐cell lung cancer (NSCLC) development through STAT3 signaling via sponging miR‐17

Huang

Lei

et al. 2018

Journal Cellular Physiology

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LncRNAs can exhibit crucial roles in the development of multiple cancers, including non-small cell lung cancer (NSCLC). Currently, we investigated the role of lncRNA H19 in NSCLC. In our study, it was found that H19 was upregulated in A549 and H1299 cells compared to normal lung epithelial BEAS-2B cells. Meanwhile, we observed that miR-17 was downregulated in NSCLC cell lines. Inhibited H19 can suppress the growth, migration, and invasion of NSCLC cells and bioinformatics search was performed to predict the correlation between H19 and miR-17. Overexpression of miR-17 was able to inhibit the progression of NSCLC cells while reversely miR-17 inhibitors reversed this process. In addition, signal transducers and activators of transcription (STAT3), as an mRNA target of miR-17, was presented in our research. Moreover, we discovered that H19 demonstrated its biological functions via regulating miR-17 and STAT3 in vitro. Silencing H19 greatly increased STAT3 expression by sponging miR-19 in vitro. It was hypothesized that H19 may serve as a competing endogenous RNA (ceRNA) to modulate STAT3 by attaching miR-17 in lung cancer. In summary, our findings indicated that H19/miR-17/STAT3 axis participated in NSCLC development. H19 could be regarded as a significant prognostic biomarker in NSCLC progression.

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“…miRNAs not only serve crucial roles in regulating various fundamental cellular processes but are also closely associated with tumorigenesis and tumor development (10,11). Previous studies have reported that miRNAs are aberrantly expressed in almost all types of human cancer, including PTC (12), colorectal cancer (13), lung cancer (14), glioblastoma (15) MicroRNA-766 inhibits papillary thyroid cancer progression by directly targeting insulin receptor substrate 2 and regulating the PI3K/Akt pathway and bladder cancer (16). Increasing evidence has revealed that various miRNAs are differentially expressed in PTC, and their dysregulation has been implicated in the regulation of PTC occurrence and development (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑766 inhibits papillary thyroid cancer progression by directly targeting insulin receptor substrate 2 and regulating the PI3K/Akt pathway

Zhao

Chen

et al. 2018

Int J Oncol

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MicroRNAs (miRNAs/miRs) are widely dysregulated in papillary thyroid cancer (PTC). Dysregulated miRNAs, together with their target genes, comprise a complex network that has been implicated in the regulation of PTC pathogenesis. Further knowledge of the functional roles of aberrantly expressed miRNAs in PTC, and the underlying molecular mechanisms, may assist in the identification of novel therapeutic targets. miR-766 has been well studied in human cancer; however, the expression status, specific roles and regulatory mechanisms of miR-766 in PTC remain unclear. The present study aimed to detect miR-766 expression in PTC tissues and cell lines, to explore the biological roles of miR-766 in the malignant biological behaviors of PTC cells, and to determine the underlying mechanism of action of miR-766 in PTC cells. The results revealed that miR-766 was downregulated in PTC tissues and cell lines, and its downregulation was strongly associated with TNM stage and lymph node metastasis. Overexpression of miR-766 inhibited PTC cell proliferation, colony formation, migration and invasion, promoted cell apoptosis and reduced tumor growth in vivo. Mechanistically, insulin receptor substrate 2 (IRS2) was identified as a direct target of miR-766 in PTC cells. IRS2 was upregulated in PTC tissues, and this was inversely correlated with miR-766 expression. Inhibition of IRS2 simulated the tumor suppressor activity of miR-766 in PTC cells. Restoration of IRS2 expression negated the tumor-suppressing effects of miR-766 overexpression on PTC cells. Notably, miR-766 directly targeted IRS2 to inhibit activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway in PTC cells in vitro and in vivo. Overall, these findings indicated that miR-766 may inhibit the malignant biological behaviors of PTC cells by directly targeting IRS2 and regulating the PI3K/Akt pathway, thus suggesting that this miRNA may be a promising therapeutic target for PTC.

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MicroRNAs as diagnostic and prognostic biomarkers in colorectal cancer

Cited by 39 publications

References 98 publications

The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer

The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer

H19 promotes non‐small‐cell lung cancer (NSCLC) development through STAT3 signaling via sponging miR‐17

MicroRNA‑766 inhibits papillary thyroid cancer progression by directly targeting insulin receptor substrate 2 and regulating the PI3K/Akt pathway

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