MicroRNAs as Oncogenes and Tumor Suppressors

Rufino‐Palomares, Eva E.; Reyes‐Zurita, Fernando J.; Lupiáñez, José A.; Medina, Pedro P.

doi:10.1002/9781118300312.ch14

Cited by 22 publications

(19 citation statements)

References 142 publications

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“…miRNAs have been implicated in the regulation of biological processes such as cell proliferation, apoptosis, metabolism, and cellular differentiation [ 8 ]. Furthermore, miRNAs have recently been reported to function as both oncogenes and suppressors of tumor progression [ 9 ]. Therefore, miRNAs expression profiles can contribute to the diagnosis and classification of cancers, and may provide clinical prognostic information and inform therapies [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

MiR-506 Is Down-Regulated in Clear Cell Renal Cell Carcinoma and Inhibits Cell Growth and Metastasis via Targeting FLOT1

et al. 2015

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BackgroundSome microRNAs (miRNAs) are abnormally expressed in cancer and contribute to tumorigenesis. In the present study, we investigated the role of miR-506 in clear cell renal cell carcinoma (ccRCC).MethodsmiR-506 expression was detected in renal cancer cell lines 786-O, ACHN, Caki-1, and Caki-2 and ccRCC specimens by quantitative real-time-PCR. We assessed the association of miR-506 expression with pathology and prognosis in ccRCC patients. We over-expressed and knocked-down miR-506 expression in two renal cancer cell lines, 786-O and ACHN, and assessed the impact on cell proliferation, migration and invasion. A luciferase reporter assay was conducted to confirm the target gene of miR-506 in renal cancer cell lines.ResultsmiR-506 was significantly down-regulated in renal cancer cell lines and ccRCC specimens. Low miR-506 expression in ccRCC specimens was associated with an advanced clinical stage and poor prognosis. miR-506 expression was an independent prognostic marker of overall ccRCC patient survival in a multivariate analysis. Over-expression of miR-506 in renal cancer cells decreased cell growth and metastasis, In contrast, down-regulation of miR-506 expression promoted renal cancer cell growth and metastasis. FLOT1, a potential target gene of miR-506, was inversely correlated with miR-506 expression in ccRCC tissues. Consistent with the effect of miR-506, knockdown of FLOT1 by siRNA inhibited cell malignant behaviors. Rescue of FLOT1 expression partially restored the effects of miR-506.ConclusionsmiR-506 exerts its anti-cancer function by directly targeting FLOT1 in renal cancer, indicating a potential novel therapeutic role in renal cancer treatment.

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Section: Introductionmentioning

confidence: 99%

MiR-506 Is Down-Regulated in Clear Cell Renal Cell Carcinoma and Inhibits Cell Growth and Metastasis via Targeting FLOT1

et al. 2015

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“…MiRNAs can regulate complicated biological behaviors, such as cell proliferation, invasion and apoptosis [9,10]. Mounting evidences also have suggested that microRNAs may function as biomarkers for detection and diagnosis of GC [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-214 promotes peritoneal metastasis through regulating PTEN negatively in gastric cancer

Xin

Bai

et al. 2016

Clinics and Research in Hepatology and Gastroenterology

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“…Ini adalah penting bagi membezakan pelbagai jenis tumor serta meramal perubahan klinikal (Kavitha et al, 2014). Perkembangan pesat teknik yang canggih seperti mikroatur, penjujukan RNA kecil, tindakbalas polimerase berantai kuantitatif (quantitative polymerase chain reaction; qPCR) dan teknologi antisense digunakan untuk memberi impak yang signifikan dalam onkologi klinikal pada masa hadapan (Rufino-Palomares et al, 2013). Sejak miRNA menjadi faktor utama dalam mengenalpasti identiti sel, miRNA juga boleh menjadi molekul yang berguna dalam diagnosis kanser.…”

Section: Mikrorna Dalam Diagnosis Dan Prognosisunclassified

Mikrorna – Molekul Versatil Dalam Kanser Tiroid

Yusof¹,

Mutalib²

2019

Prog Micobes Mol Biol

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MikroRNA adalah molekul bebenang tunggal RNA kecil, dengan kepanjangan di antara 18 hingga 25 nukleotida. Molekul pengawalatur ini mampu menyasarkan lebih dari satu gen, dan dianggarkan mengawal 30% daripada keseluruhan gen manusia. MikroRNA tidak diendahkan oleh saintis beberapa dekad sebelum ini kerana ia tidak mengekod sebarang protein lantas dianggap jujukan sampah (junk sequence), namun sejak penemuan lin-4 yang mengawalselia perkembangan larva Caenorhabditis elegans, semakin banyak kajian bertumpu ke arah molekul ini. Sebagai molekul pengawalatur (regulatory molecule), mikroRNA adalah calon kajian yang sesuai untuk penyelidikan kanser tiroid di mana landskap mutasi genomnya secara relatif lebih senyap berbanding kanser lain. Hanya sebilangan kecil gen bermutasi dikenalpasti dalam kanser tiroid dan mekanisme molekular patogenesis kanser ini masih kurang jelas. Artikel ini bertujuan untuk mendedahkan pembaca terhadap mikroRNA dan faedahnya dalam kajian kanser tiroid, serta perkembangan terkini kajian tentang mikroRNA dalam kanser ini. Penekanan terhadap peranan mikroRNA dalam kanser tiroid, dengan memfokus kepada versatiliti molekul ini dalam aplikasi diagnosis, prognosis, serta sebagai biopenanda dalam mengenalpasti pesakit yang tidak avid terhadap radioiodin akan turut dibincangkan.

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MicroRNAs as Oncogenes and Tumor Suppressors

Cited by 22 publications

References 142 publications

MiR-506 Is Down-Regulated in Clear Cell Renal Cell Carcinoma and Inhibits Cell Growth and Metastasis via Targeting FLOT1

MiR-506 Is Down-Regulated in Clear Cell Renal Cell Carcinoma and Inhibits Cell Growth and Metastasis via Targeting FLOT1

MicroRNA-214 promotes peritoneal metastasis through regulating PTEN negatively in gastric cancer

Mikrorna – Molekul Versatil Dalam Kanser Tiroid

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