MicroRNAs as potential diagnostic and prognostic biomarkers in melanoma

Mirzaei, Hamed; Gholamin, Sharareh; Shahidsales, Soodabeh; Sahebkar, Amirhossein; Jaafari, Mahmoud Reza; Mirzaei, Hamid Reza; Hassanian, Seyed Mahdi

doi:10.1016/j.ejca.2015.10.009

Cited by 166 publications

(156 citation statements)

References 101 publications

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“…According to these hypothesis, the identification of changes in the expression levels of individual or multiple miRNAs directly into peripheral blood, or in urine, may represent a new strategy for the early detection of cancer and for the prediction of cancer recurrence development [38–41]. …”

Section: Discussionmentioning

confidence: 99%

Computational identification of microRNAs associated to both epithelial to mesenchymal transition and NGAL/MMP-9 pathways in bladder cancer

et al. 2016

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Bladder cancer is one of the leading cancer of the urinary tract. It is often diagnosed at advanced stage of the disease. To date, no specific and effective early detection biomarkers are available. Cancer development and progression are associated with the involvement of both epithelial-mesenchymal transition (EMT) and tumor microenvironment of which NGAL/MMP-9 complex represents the main player in bladder cancer. It is known that change in microRNAs (miRNAs) expression may result in gene modulation. Therefore, the identification of specific miRNAs associated with EMT pathway and NGAL/MMP-9 complex may be useful to detect the development of bladder cancer at early stages.On this ground, the expression levels of miRNAs in public available datasets of bladder cancer containing data of non-coding RNA profiling was evaluated. This analysis revealed a group of 16 miRNAs differentially expressed between bladder cancer patients and related healthy controls. By miRNA prediction tool (mirDIP), the relationship between the identified miRNAs and the EMT genes was established. Using the DIANA-mirPath (v.2) software, miRNAs, able to modulate the expression of NGAL and MMP-9 genes, were recognized.The results of this study provide evidence that the downregulated hsa-miR-145-5p and hsa-miR-214-3p may modulate the expression of both EMT and NGAL/MMP-9 pathways. Therefore, further validation analyses may confirm the usefulness of these selected miRNAs for predicting the development of bladder cancer at the early stage of the disease.

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Section: Discussionmentioning

confidence: 99%

Computational identification of microRNAs associated to both epithelial to mesenchymal transition and NGAL/MMP-9 pathways in bladder cancer

et al. 2016

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“…In addition, LNM and DM are important for cancer patient TNM (tumor–node–metastasis) staging, and for predicting patient prognosis. Since the precise metastasis mechanisms remain unknown in most cancers, molecular biomarkers play critical roles in cancer diagnosis, prognosis and treatment [26–27]. Finding new molecular markers that accurately predict tumor metastasis risk are of paramount importance for improving patient outcomes.…”

Section: Discussionmentioning

confidence: 99%

BRAF-activated lncRNA predicts gastrointestinal cancer patient prognosis: a meta-analysis

Fan

et al. 2016

Oncotarget

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BRAF activated non-coding RNA (BANCR) is often dysregulated in cancer. We performed a meta-analysis to clarify its functions as a prognostic indicator in malignant tumors. We searched the PubMed, Medline, OVID, Cochrane Library, and Web of Science databases to identify BANCR-related studies. Nine original studies and 898 total patients were included in the meta-analysis. Hazard ratios (HR) and 95% confidence intervals (CI) were extracted from the included studies to determine the relationship between BANCR expression and patient overall survival (OS). Odds ratios (OR) were calculated using RevMan 5.3 software to assess associations between BANCR expression and pathological parameters. High BANCR expression correlated with lymph node metastasis (LNM) (OR = 3.41, 95% CI: 1.82–6.37, P = 0.0001), distant metastasis (DM) (OR = 2.98, 95% CI: 1.76–5.07, P < 0.0001), tumor stage (OR = 3.11, 95% CI: 1.89–5.12, Z = 3.25, P < 0.0001), and poor OS (pooled HR = 1.98, 95% CI: 1.20–3.27, P = 0.008) in gastrointestinal (GI) cancer patients, but not in non-GI cancer patients. Our results support the notion that BANCR as a promising prognostic biomarker in Chinese patients with GI cancer.

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“…In Table 1 underlined miRNAs are those with possible prognostic and/or diagnostic role in melanoma as reported in some published studies [77, 78]. As shown in Figure 2A and 2B, no miRNAs resulted to be in common among the four groups; we found only one upregulated miRNA (miR-126) in common between groups 1 and 2, one upregulated miRNA in common between groups 3 and 4 (miR-222), four down-regulated miRNAs (miR-196a, miR-374, miR-454-3p and miR-324-5p) in common between the same groups 1 and 2 and two downregulated miRNAs in common between groups 2 and 4 (let-7i and miR-211).…”

Section: Deregulated Mirnas Converge On a Set Of Key Intracellular Pamentioning

confidence: 99%

MicroRNAs in melanoma development and resistance to target therapy

et al. 2017

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microRNAs constitute a complex class of pleiotropic post-transcriptional regulators of gene expression involved in the control of several physiologic and pathologic processes. Their mechanism of action is primarily based on the imperfect matching of a seed region located at the 5′ end of a 21-23 nt sequence with a partially complementary sequence located in the 3′ untranslated region of target mRNAs. This leads to inhibition of mRNA translation and eventually to its degradation. Individual miRNAs are capable of binding to several mRNAs and several miRNAs are capable of influencing the function of the same mRNAs. In recent years networks of miRNAs are emerging as capable of controlling key signaling pathways responsible for the growth and propagation of cancer cells. Furthermore several examples have been provided which highlight the involvement of miRNAs in the development of resistance to targeted drug therapies. In this review we provide an updated overview of the role of miRNAs in the development of melanoma and the identification of the main downstream pathways controlled by these miRNAs. Furthermore we discuss a group of miRNAs capable to influence through their respective up- or down-modulation the development of resistance to BRAF and MEK inhibitors.

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MicroRNAs as potential diagnostic and prognostic biomarkers in melanoma

Cited by 166 publications

References 101 publications

Computational identification of microRNAs associated to both epithelial to mesenchymal transition and NGAL/MMP-9 pathways in bladder cancer

Computational identification of microRNAs associated to both epithelial to mesenchymal transition and NGAL/MMP-9 pathways in bladder cancer

BRAF-activated lncRNA predicts gastrointestinal cancer patient prognosis: a meta-analysis

MicroRNAs in melanoma development and resistance to target therapy

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