MicroRNAs in esophageal squamous cell carcinoma: Application in prognosis, diagnosis, and drug delivery

Mohammadi, Elahe; Aliarab, Azadeh; Babaei, Ghader; Habibi, Nasim Kouhi; Jafari, Seyyed Mehdi; Mir, Seyed Mostafa; Memar, Mohammad Yousef

doi:10.1016/j.prp.2022.154196

Cited by 12 publications

(10 citation statements)

References 93 publications

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“…19,20 Multiple research established that miRNAs acted as oncogenes in ESCC malignancies with substantial potential in diagnosing, treating, and prognosing with ESCC. 21,22 MiR-601 could negatively regulating HDAC6, thereby inhibiting ESCC progression. 23 Moreover, these heightened miR-106b-5p levels suppressed HPGD expression, which constituted crucial factors that impact the progression and prognosis of patients with ESCC.…”

Section: Discussionmentioning

confidence: 99%

“…Consequently, it holds immense significance to explore potential mechanisms and identify new biomarkers as they significantly contribute to the early detection and treatment guidance for patients with ESCC 19,20 . Multiple research established that miRNAs acted as oncogenes in ESCC malignancies with substantial potential in diagnosing, treating, and prognosing with ESCC 21,22 . MiR‐601 could negatively regulating HDAC6, thereby inhibiting ESCC progression 23 .…”

Section: Discussionmentioning

confidence: 99%

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MicroRNA‐196a‐5p facilitates the onset and progression via targeting ITM2B in esophageal squamous cell carcinoma

Xian,

Yang,

Liu

et al. 2024

Pathology International

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Esophageal squamous cell carcinoma (ESCC) is a prevalent malignancy affecting the digestive tract, with an increasing incidence rate worldwide. Recently, numerous studies revealed that microRNAs were associated with gene expression regulation, particularly their involvement in the regulation of tumor cells, garnering widespread attention. Here, we discovered that miR‐196a‐5p was significantly upregulated in both ESCC tissues and cells, which was correlated with an unfavorable prognosis. Series functional in vitro investigations have confirmed that silencing miR‐196a‐5p obviously restrained the ESCC cells malignant phenotypes and promoted apoptosis. Bioinformatics analysis and rescue experiments revealed that miR‐196a‐5p directly targeted ITM2B, exerting influence on the development of ESCC cells through negative regulation of ITM2B expression. Xenograft mouse models were established for conducting in vivo experiments, providing further confirmation of the regulatory mechanism and biological significance of the miR‐196a‐5p/ITM2B axis in ESCC. Our research demonstrated miR‐196a‐5p promoted ESCC malignant progression by interacting with ITM2B, thereby providing novel clues and potential targets for the new diagnosis and thereby of ESCC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

MicroRNA‐196a‐5p facilitates the onset and progression via targeting ITM2B in esophageal squamous cell carcinoma

Xian,

Yang,

Liu

et al. 2024

Pathology International

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“…The significant transcriptomes associated with ESCC have been widely investigated through high-throughput approaches. For example, known ESCC-related miRNAs include miR-23b-5p, miR-877-3p, and miR-17-92, among others (13)(14)(15)(16). Several published works demonstrated that chemotherapy resistance can be affected by mRNAs like TUG1, ZFX, and NRF2, and miRNAs like miR-130a-3p, miR-125a-5p, and miR-224 (17)(18)(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Use of exosome transcriptome-based analysis to identify novel biomarkers in patients with locally advanced esophageal squamous cell carcinoma undergoing neoadjuvant chemoradiotherapy

Yang¹,

Zhang²,

Liu³

et al. 2023

Ann Transl Med

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Background: The prognosis of esophageal squamous cell carcinoma (ESCC) is improved by neoadjuvant chemoradiotherapy (nCRT), especially for patients with pathologic complete response (pCR). Despite the efforts to predict treatment response using multimodality, no molecule has proven to be a strong biomarker.This study aimed to profile the expression of exosome transcriptome that could predict pCR in ESCC before and after nCRT.Methods: We collected paired blood samples of 15 patients with ESCC who received nCRT and radical surgery. They were divided into 3 groups: (A) residual tumor in the first clinical response evaluation (CRE-1), (B) no residual tumor in CRE-1 but with residual tumor in CRE-2 which was performed after 5-6 weeks, and (C) no residual tumor in CRE-1 or CRE-2. For each patient, the blood sample was collected before nCRT (time point 0); and then 6 weeks after nCRT, the clinical response was evaluated, and another blood sample was collected (time point 1).Results: Using the intersection of different sets, we found 23 progression-associated messenger RNAs (mRNAs) and 67 remission-associated mRNAs. Between remission-associated mRNAs and the targets of progression-associated (carcinogenic) microRNAs (miRNAs), the intersection was acquired, and 2 miRNA-mRNA networks (IFIT2-miR-3615-IFIT2-miR-484 and BTN3A3-miR-6803-3p) were identified. Among the intersection of progression-associated (carcinogenic) mRNAs and the targets of remission-associated miRNAs, there is a network with miR-132-3p (remission-associated miRNA) located at the core, matched with DICER1, KLHL8, ANKRD12, ASH1L, and IMP4.Conclusions: Our findings identified altered plasma exosome RNAs among the different groups and between different time points of nCRT, as well as the corresponding enrichments and regulatory networks, which may serve as potentially predictors of treatment response for patients with ESCC after nCRT.

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“…Growing evidence has shown the importance of miRNA in tumorigenesis and cancer development. The most recent findings on the potential benefits of mRNAs indicate they may serve as prognostic factors in ESCC [49] . For instance, miR-10, miR-18, miR-19, miR-21, miR-25, miR-31, miR-129, miR-365, miR-451, miR-1246, and miR-1322 are upregulated in tumor tissues of ESCC patients compared with normal tissues; moreover, miR-155, miR-203, miR-205, miR375, and miR-718 are downregulated in ESCC patients compared to control groups 50 , 51 .…”

Section: Discussionmentioning

confidence: 99%

An integrated analysis of dysregulated SCD1 in human cancers and functional verification of miR-181a-5p/SCD1 axis in esophageal squamous cell carcinoma

Wang,

Chang,

Shiu

et al. 2023

Computational and Structural Biotechnology Journal

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MicroRNAs in esophageal squamous cell carcinoma: Application in prognosis, diagnosis, and drug delivery

Cited by 12 publications

References 93 publications

MicroRNA‐196a‐5p facilitates the onset and progression via targeting ITM2B in esophageal squamous cell carcinoma

MicroRNA‐196a‐5p facilitates the onset and progression via targeting ITM2B in esophageal squamous cell carcinoma

Use of exosome transcriptome-based analysis to identify novel biomarkers in patients with locally advanced esophageal squamous cell carcinoma undergoing neoadjuvant chemoradiotherapy

An integrated analysis of dysregulated SCD1 in human cancers and functional verification of miR-181a-5p/SCD1 axis in esophageal squamous cell carcinoma

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