MicroRNAs in lung cancer

Castro, Diana; Moreira, Márcia Zabdiele; Gouveia, Alexandra; Pozza, Daniel Humberto; Mello, Ramon Andrade De

doi:10.18632/oncotarget.20955

Cited by 86 publications

(61 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MiRNAs have been associated with the initiation and progression of NSCLC (31)(32)(33). As such, a comprehensive understanding of the association between dysregulated miRNA expression and NSCLC may contribute to the identification of novel therapeutic methods for patients with this disease.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑433 reduces cell proliferation and invasion in non‑small cell lung cancer via directly targeting E2F transcription factor 3

Liu

Zhang

et al. 2018

Mol Med Report

View full text Add to dashboard Cite

MicroRNAs (miRNA/miRs) have been associated with the initiation and progression of non‑small‑cell lung cancer (NSCLC). Hence, a comprehensive understanding of the association between dysregulated miRNAs and NSCLC may contribute to the identification of novel therapeutic methods for patients with NSCLC. MiRNA‑433 (miR‑433) has been reported to be dysregulated in numerous types of human cancers; however, its expression pattern, biological roles and associated mechanisms in NSCLC require further investigation. The present study aimed to detect miR‑433 expression and determine its roles and underlying molecular mechanisms in NSCLC. In the present study, reverse transcription‑quantitative polymerase chain reaction revealed that miR‑433 was significantly downregulated in NSCLC tissues and cell lines. This decreased miR‑433 expression was strongly associated with the tumor node metastasis stage and lymph node metastasis of patients with NSCLC. Cell Counting kit‑8 and cell invasion assays revealed that the resumption of miR‑433 expression decreased the proliferation and invasion of NSCLC cells. Bioinformatics analysis predicted E2F transcription factor 3 (E2F3) as a potential target of miR‑433. Luciferase reporter assay, RT‑qPCR and western blot analysis further demonstrated that E2F3 was a direct target of miR‑433 in NSCLC. E2F3 downregulation induced by small interfering RNA exhibited inhibitory effects similar to those of miR‑433 overexpression in NSCLC cells, and the restored E2F3 expression counteracted the suppressive effects on NSCLC cells induced by miR‑433 overexpression. Therefore, miR‑433 may inhibit the progression of NSCLC, at least in part, by targeting E2F3. The present study indicated that miR‑433 may be investigated as an innovative candidate target for the therapy of patients with this fatal disease.

show abstract

Section: Discussionmentioning

confidence: 99%

MicroRNA‑433 reduces cell proliferation and invasion in non‑small cell lung cancer via directly targeting E2F transcription factor 3

Liu

Zhang

et al. 2018

Mol Med Report

View full text Add to dashboard Cite

show abstract

“…As a result, it might induce the capability of sustaining proliferation, growth suppression, cell death, activating migration, enhancing immune response and inducing angiogenesis. Abnormal miRNA expression has been reported to be associated with many diseases, including some cancers . Therefore, miRNA are known to play pivotal roles in cancer progression and thought to be promising diagnostic and prognostic biomarkers for cancer .…”

Section: Introductionmentioning

confidence: 99%

“…Abnormal miRNA expression has been reported to be associated with many diseases, including some cancers . Therefore, miRNA are known to play pivotal roles in cancer progression and thought to be promising diagnostic and prognostic biomarkers for cancer . As in cancer, clinical research on miRNA expression profile is also expected to contribute to the progression of diagnostic and therapeutics for inflammatory respiratory diseases.…”

Section: Introductionmentioning

confidence: 99%

Molecular techniques for respiratory diseases: MicroRNA and extracellular vesicles

et al. 2019

View full text Add to dashboard Cite

miRNA are a class of evolutionarily conserved non-coding 19-to 22-nt regulatory RNA. They affect various cellular functions through modulating the transcriptional and post-transcriptional levels of their target mRNA by changing the stability of protein-coding transcripts or attenuating protein translation. miRNA were discovered in the early 1990s, and they have been the focus of new research in both basic and clinical medical sciences. Today, it has become clear that specific miRNA are linked to the pathogenesis of respiratory diseases, as well as cancer and cardiovascular disease. In addition, EV, including exosomes, which are small membrane-bound vesicles secreted by cells, were found to contain various functional miRNA that can be used for diagnostic and therapeutic purposes. As body fluids, such as blood and respiratory secretions, are major miRNA sources in the body, EV carrying extracellular miRNA are considered potentially useful for the diagnosis and assessment of pathological conditions, as well as the treatment of respiratory or other diseases. Although research in the field of lung cancer is actively progressing, studies in other respiratory fields have emerged recently as well. In this review, we provide an update in the topics of miRNA and EV focused on airway inflammatory diseases, such as asthma and COPD, and explore their potential for clinical applications on respiratory diseases.

show abstract

“…Epigenetic regulation, such as histone modification and DNA methylation, often occur alongside genetic regulation to affect the development of malignancies. In addition, non-coding RNA, including MicroRNAs (miRNA) and lncRNA, is reported to take indispensable roles in tumor formation and progression [12,13]. However, the exact functions and regulatory mechanisms of these epigenetic regulators in liver cancer remain poorly understood.…”

Section: Introductionmentioning

confidence: 99%

miR-1269a promotes tumor growth and progression of liver cancer via regulating Rbms3/c-Myc axis

Zhou

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: MicroRNAs play important roles in regulating liver cancer formation, progression and metastasis. miR-1269a, a cancer associated miRNA, its role in liver cancer is still unclear. Methods: The clinical, survival and miR-1269a expression of both liver cancer and normal tissues were analyzed from the TCGA database. The effects of miR-1269a on liver cancer cells were investigated through cell counting kit-8 assay, Ki67 immunofluorescence staining and animal models (Balb/c nude mice). The interaction between miR-1269a and Rbms3 was investigated via luciferase reporter assay. Results: Here, we showed that miR-1269a was highly expressed in primary patient tumor tissues using the TCGA database. miR-1269a inhibition through overexpressing its sponge in HepG2 and Hep3B cells significantly repressed cell proliferation, but had no effect on cell apoptosis and migration. Through directly targeting the 3’ untranslated region, miR-1269a inhibits Rbms3 expression. Rbms3 inhibition promoted the expression of c-Myc, resulting in the increased proliferation of liver cancer cells. Conclusions: Our results reveal a novel miR-1269a/Rbms3/c-Myc axis, which plays a critical role in liver tumor growth and progression, and may serve as a promising biomarker for the early diagnosis of liver cancer, as well as a possible therapeutic target in liver cancer treatments.

show abstract

MicroRNAs in lung cancer

Cited by 86 publications

References 43 publications

MicroRNA‑433 reduces cell proliferation and invasion in non‑small cell lung cancer via directly targeting E2F transcription factor 3

MicroRNA‑433 reduces cell proliferation and invasion in non‑small cell lung cancer via directly targeting E2F transcription factor 3

Molecular techniques for respiratory diseases: MicroRNA and extracellular vesicles

miR-1269a promotes tumor growth and progression of liver cancer via regulating Rbms3/c-Myc axis

Contact Info

Product

Resources

About