Microsatellite Instability in Greek Colorectal Carcinoma Patients: Clinicopathological and Molecular Correlations

Katafygiotis, Patroklos; Sakellariou, Stratigoula; Chatziandreou, Ilenia; Giannopoulou, Ioanna; Thymara, Irene; Saetta, Angelica A.; Korkolopoulou, Penelope

doi:10.21873/anticanres.13851

Cited by 3 publications

(4 citation statements)

References 42 publications

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“…In most of the previous studies, MSI cases have been more common in the ages below 50 from European or African populations (12,13). However, this has not been confirmed in other studies from other geographic areas such as Greece (14). In our study, MSI tumors were more common in the right colon (although it has not been statistically significant).…”

Section: Discussioncontrasting

confidence: 91%

“…Most of our cases were in the stage II both in MSI and MSS colorectal cancer groups, thus, there was no difference between two groups according to the stage, but in most of the previous reports, MSS tumors were presented in higher stage (11,14).…”

Section: Discussionmentioning

confidence: 48%

“…In our study, MSI tumors were more common in the right colon (although it has not been statistically significant). In majority of the previous reports, MSI colorectal cancers were more common in the right colon (11,14).…”

Section: Discussionmentioning

confidence: 93%

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Microsatellite Instability and Colorectal Cancer, Immunohistochemical and Molecular Evaluation by Using DNA Sequencing: A Single Center Experience

et al. 2021

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Scan to discover onlineBackground & Objective: Microsatellite instability is common in familial colorectal cancers. It can be tested by the molecular and immunohistochemical methods. There are very few studies which address comparing the clinicopathological characteristics of microsatellite stable (MSS) and microsatellite unstable (MSI) colorectal cancers from Iran. In this study, we aimed to evaluate the clinicopathological and immunohistochemical findings of MSS and MSI colorectal cancers in our Center as the largest Center of gastrointestinal surgery and oncology in the South of Iran. We also compared the immunohistochemical method vs. molecular study using DNA sequencing.Methods: For 5 years (2015-2019), 34 patients who underwent operation in the affiliated Hospitals of Shiraz University of Medical Sciences were clinically suspected to microsatellite instability (MSI). The molecular diagnostic tests with DNA sequencing were performed. Clinicopathological and immunohistochemical findings of MSI colorectal cancers were compared with those who were stable.Results: In the South of Iran, MSI colorectal cancers were more common in males. These tumors were more common in the right side with more tendencies to produce mucin with lymphocytic infiltration. Conclusion:Immunohistochemistry would be a specific method for diagnosis of MSI colorectal cancers but may be associated with high rate of false negative results and of low sensitivity. Therefore, we recommend performing molecular studies by DNA sequencing in those colon cancers with clinical suspicion for MSI and negative immunohistochemical findings.

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Section: Discussioncontrasting

confidence: 91%

Section: Discussionmentioning

confidence: 48%

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Microsatellite Instability and Colorectal Cancer, Immunohistochemical and Molecular Evaluation by Using DNA Sequencing: A Single Center Experience

et al. 2021

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“…A higher density of eosinophilic leukocytes and intraepithelial T-cells has been shown in the proximal colon (17,18). Tumours from both parts of the colon are further distinguished by certain clinicopathological properties that can influence the long-term survival of patients, both after resection of primary tumour and after operations for CLMs (19,20). RCRC are more common in the older population with frequent comorbidities, in women, in patients with other malignancies, and those with insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Long-term Results of Surgery for Colorectal Liver Metastases in Terms of Primary Tumour Location and Clinical Risk Factors

Třeška¹,

Skála²,

Procházková³

et al. 2020

In Vivo

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Background/Aim: The aim of the study was to evaluate the influence of primary tumour location and clinical risk factors for long-term results of surgery for colorectal liver metastases (CLMs). Patients and Methods: Overall survival (OS) and recurrence-free survival (RFS) were evaluated in 636 patients. Patients were divided by tumour location (right-/left-sided colorectal cancer: RCRC/LCRC; rectal cancer), and age, gender, number and size of CLMs, type of liver surgery and interval from primary operation were evaluated. Results: One-, 3-and 5-year OS and RFS were independent of primary tumour location (p<0.59). CLM diameter was negatively associated with OS for the whole cohort (p<0.002), and RCRC (p<0.03) and LCRC (p<0.04) groups, as well as for RFS of those with LCRC (p<0.04). CLM number was negatively associated with RFS for the whole cohort (p<0.0001), RCRC (p<0.02), LCRC (p<0.0001) and RC (p<0.02). Radiofrequency ablation and combined procedures led to worse OS for the whole cohort (p<0.03), and to worse RFS for the whole cohort (p<0.0003) and for those with LCRC (p<0.03). A shorter interval between primary colorectal cancer surgery and CLMs procedure was risky for poor OS and RFS of patients with CLMs from RCRC (p<0.05), LCRC (p<0.05) and RC (p<0.02). Conclusion: Primary tumour location together with clinical risk factors are important for longterm results of surgery CLMs.

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An Investigation on the Results of Cytopathologic Tests of Pancreatobiliary System Performed in the Pathology Department in Iran

et al. 2021

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Scan to discover onlineBackground & Objective: Pancreatobiliary system disorders commonly include inflammatory diseases and tumors. Diagnosis of pancreatic cancer is challenging and is mostly achieved when the disease has extensively progressed, and metastasis has occurred. Therefore, this study was performed to evaluate cytopathology in the diagnosis of Pancreatobiliary malignancies, which can improve diagnostic adequacy and accuracy.Methods: A total of 116 cytopathologic results of the Pancreatobiliary system, performed in the Pathology Department of Taleghani Hospital, Tehran, Iran during 2017-2018 were selected and examined in this observational study. The frequency of different results was determined and compared with other variables. Results:The most common location of the lesions was the pancreas (47%). The lesions were categorized as malignant, benign, negative, suspicious for malignancy (SFM), and atypical in 28%, 10%, 24%, 14%, and 9% of the cases, respectively. In other cases, lesions were considered non-diagnostic. Rapid on-site evaluation (ROSE) was conducted in 25% of patients. Compatibility of the initial and final diagnoses was 100%, 50%, and 60% in cases with "malignant", "benign", and "negative" diagnoses, respectively. The sensitivity, specificity, as well as positive and negative predictive values of cytopathology in the diagnosis of Pancreatobiliary lesions were 75.8%, 92.3%, 95.9%, and 61.5%, respectively. Conclusion:Our findings indicated that half of the lesions of the Pancreatobiliary system were positive, SFM, and atypical. Fine-needle aspiration (FNA) and endoscopic ultrasoundguided FNA (EUS-FNA) were effective modalities in diagnosing Pancreatobiliary malignancies. The most important point in our experience is the increase in diagnostic sensitivity in the presence of ROSE. Therefore, the simultaneous use of ROSE and EUS-FNA can reduce the need for re-sampling.

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Microsatellite Instability in Greek Colorectal Carcinoma Patients: Clinicopathological and Molecular Correlations

Cited by 3 publications

References 42 publications

Microsatellite Instability and Colorectal Cancer, Immunohistochemical and Molecular Evaluation by Using DNA Sequencing: A Single Center Experience

Microsatellite Instability and Colorectal Cancer, Immunohistochemical and Molecular Evaluation by Using DNA Sequencing: A Single Center Experience

Long-term Results of Surgery for Colorectal Liver Metastases in Terms of Primary Tumour Location and Clinical Risk Factors

An Investigation on the Results of Cytopathologic Tests of Pancreatobiliary System Performed in the Pathology Department in Iran

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