Microsatellite Status of Primary Colorectal Cancer Predicts the Incidence of Postoperative Colorectal Neoplasms

Takiyama, Aki; Tanaka, Toshiaki; Yamamoto, Yasutake; Hata, Keisuke; Ishihara, Soichiro; Nozawa, Hiroaki; Kawai, Kazushige; Kiyomatsu, Tomomichi; Nishikawa, Takeshi; Otani, Kensuke; Sasaki, Kazuhito; Watanabe, Toshiaki

doi:10.21873/anticanres.12020

Cited by 4 publications

(3 citation statements)

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“…According to the GLOBOCAN project of the WHO Cancer Research Center, the number of new cases of CRC in 2018 was about 1.8 million, and the number of deaths was about 880,000. The incidence of CRC is related to factors such as age, region, and gender ( Takiyama et al, 2017 ; Zhou et al, 2022 ). The pathological types of CRC are divided into ulcerative, raised, and infiltrating.…”

Section: Discussionmentioning

confidence: 99%

Effects of GLP-1 Receptor Agonists on Biological Behavior of Colorectal Cancer Cells by Regulating PI3K/AKT/mTOR Signaling Pathway

Tong

Peng²,

Chen³

et al. 2022

Front. Pharmacol.

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Colorectal cancer (CRC) has become one of the top ten malignant tumors with a high incidence rate and mortality. Due to the lack of a good CRC screening program, most of the CRC patients are being transferred at the time of treatment. The conventional treatment cannot effectively improve the prognosis of CRC patients, and the target drugs can significantly prolong the overall survival of patients in the advanced stage. However, the use of single drug may lead to acquired drug resistance and various serious complications. Therefore, combined targeted drug therapy is the main alternative treatment with poor effect of single targeted drug therapy, which has important research significance for the treatment of CRC. Therefore, this study intends to culture CRC cell lines in vitro at the cell level and intervene with the GLP-1 receptor agonist liraglutide. The effects of liraglutide on the PI3K/Akt/mTOR signal pathway and CRC cell proliferation, cycle, migration, invasion, and apoptosis are explored by detecting cell proliferation, cycle, migration, invasion, and apoptosis and the expression of related mRNA and protein. The results showed that liraglutide, a GLP-1 receptor agonist, could block the CRC cell cycle, reduce cell proliferation, migration, and invasion and promote apoptosis by inhibiting the PI3K/Akt/mTOR signal pathway.

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Section: Discussionmentioning

confidence: 99%

Effects of GLP-1 Receptor Agonists on Biological Behavior of Colorectal Cancer Cells by Regulating PI3K/AKT/mTOR Signaling Pathway

Tong

Peng²,

Chen³

et al. 2022

Front. Pharmacol.

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show abstract

“…of microsatellite markers as BAT25, BAT26, D2S123, D5S346, and D17S2720; the amplification of BAT26 (100%); and the reduction of D17S2720 (85.4%), confirming its use as a prognostic marker in colorectal carcinogenesis. Other studies investigating MSI status showed a high association among microsatellite loci, BAT25 and BAT26, and the more aggressive histopathological types (tubulovillous/villous adenoma) of SCRC [18].…”

mentioning

confidence: 87%

“…Some papers present the MSI as a marker of a significant prognostic factor in the early SCRC stages [3,15,18]. Zhang & collaborators [19] showed that the MS-I status was found to be significantly correlated with good or moderate histopathological differentiation associated with low carcinoembryonic antigens and CA-19-9 antigen values.…”

Section: Microsatellite Instability (Msi)mentioning

confidence: 99%

A Summary of the Main Biomarkers for Diagnosis and Prognosis of Sporadic Colorectal Cancer: A Review

Goloni-Bertollo

2019

ARGH

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Sporadic colorectal cancer (SCRC) affects regions of the large intestine (colon) and rectum that are not of family origin. The carcinogenesis process involves the interaction between environmental and genetic factors. This tumor is characterized by intestinal obstruction, bleeding (hematochezia, enterorrhagia), an altered bowel habit, and systemic conditions, such as weight loss. Some risk factors for SCRC are age over 60 years, a diet with high saturated fat, red meat, alcohol consumption, and smoking. An early diagnosis is essential for effective patient treatment and survival. Finding more effective and less invasive tumor, such as biomarkers, are important for ensuring that people participate in cancer screenings. Some studies have evaluated molecular biomarkers, such as micro ribonucleic acids (microRNAs, or miRNAs) and genes, in relation to the pathways leading to SCRC carcinogenesis, and it has been found that many of these biomarkers are highly expressed in this type of tumor. This review shows data from the literature search in PubMed in the period from January 2017 to April 2018 focusing news biomarkers in SCRC, including microsatellite instability, genes, and micro ribonucleic acids (micro RNAs, or miRNAs), associated with diagnosis, prognosis, and treatment in blood, tissue and feces samples. Thus, this literature review shows that microsatellite instability and gene markers have been extensively studied and characterized as biomarkers in the diagnosis, prognosis, and treatment of SCRC. In addition, some miRNAs have been demonstrated as good noninvasive biomarkers in stool and plasma samples.

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Benefits of a laparoscopic approach for second colorectal resection after colectomy or proctectomy –a retrospective study-

et al. 2023

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Background A laparoscopic approach generally provides several benefits in patients who undergo colon or rectal surgery without jeopardizing oncological outcomes. However, there is a paucity of studies on comparative outcomes of laparoscopic versus open approaches for second primary colorectal lesions after colectomy or proctectomy. Methods From patients with colorectal disease who underwent surgery between 2008 and 2022 at our hospital, we collected 69 consecutive patients who had previous colorectal surgery for this retrospective study. Based on the second surgery approach (laparoscopic or open), patients were classified into the Lap (n = 37) or Op group (n = 32). Patients’ baseline data and perioperative and postoperative outcomes were compared between the two groups. Results Four patients (11%) of the Lap group needed conversion to laparotomy. The intraoperative blood loss was lower in the Lap group than the Op group (median: 45 ml vs. 205 ml, p = 0.001). The time to first bowel movement was shorter in the Lap group than the Op group (median: 2.8 days vs. 3.6 days, p = 0.007). The operative time, frequencies of postoperative morbidities, and overall survival did not differ between the two groups. Conclusion Laparoscopic surgery appeared feasible and beneficial for selected patients undergoing second colorectal resection after colectomy or proctectomy regarding blood loss and bowel function recovery without affecting other outcomes.

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Microsatellite Status of Primary Colorectal Cancer Predicts the Incidence of Postoperative Colorectal Neoplasms

Abstract: The MS status of primary colorectal cancer influenced the risk of postoperative colorectal neoplasms.

Cited by 4 publications

References 0 publications

Effects of GLP-1 Receptor Agonists on Biological Behavior of Colorectal Cancer Cells by Regulating PI3K/AKT/mTOR Signaling Pathway

Effects of GLP-1 Receptor Agonists on Biological Behavior of Colorectal Cancer Cells by Regulating PI3K/AKT/mTOR Signaling Pathway

A Summary of the Main Biomarkers for Diagnosis and Prognosis of Sporadic Colorectal Cancer: A Review

Benefits of a laparoscopic approach for second colorectal resection after colectomy or proctectomy –a retrospective study-

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