Microscopic colitis: a narrative review with clinical approach

Mosso, Elena; Boano, Valentina; Grassini, Mario; Battaglia, Edda; Pellicano, Rinaldo

doi:10.23736/s1121-421x.18.02539-4

Cited by 4 publications

(3 citation statements)

References 60 publications

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“…Microscopic colitis (MC) is an inflammation of the large intestine, diagnosed in the presence of microscopic alterations of colonic mucosa that can cause watery diarrhea and cramping in patients. Lymphocytic colitis (LC) and collagenous colitis (CC) are two types of MC; it is hard to identify whether these are the different expressions of one unique disease or if they are distinct conditions [53]. A small portion of patients (1-6%) with MC are resistant to medical treatment.…”

Section: Microscopic Colitismentioning

confidence: 99%

Current Status and Future Therapeutic Options for Fecal Microbiota Transplantation

et al. 2022

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The intestinal microbiota plays an important role in maintaining human health, and its alteration is now associated with the development of various gastrointestinal (ulcerative colitis, irritable bowel syndrome, constipation, etc.) and extraintestinal diseases, such as cancer, metabolic syndrome, neuropsychiatric diseases. In this context, it is not surprising that gut microbiota modification methods may constitute a therapy whose potential has not yet been fully investigated. In this regard, the most interesting method is thought to be fecal microbiota transplantation, which consists of the simultaneous replacement of the intestinal microbiota of a sick recipient with fecal material from a healthy donor. This review summarizes the most interesting findings on the application of fecal microbiota transplantation in gastrointestinal and extraintestinal pathologies.

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Section: Microscopic Colitismentioning

confidence: 99%

Current Status and Future Therapeutic Options for Fecal Microbiota Transplantation

et al. 2022

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“…This latter sign is usually located in ascending and transverse colon and it is due to contrast enhancement of mucosal sinuses in the longitudinal section of the bowel on computed tomography (CT) scans, enlarged from mucosal thickening. 32,43 Endoscopic appearance of EC is variable and, in most cases, similarly to microscopic colitis shows normal mucosa; 57 several non-specific endoscopic findings might be present, such as erythematous patchy mucosa, ulcers, polyps and pseudo-polyps. 3,26 Histology is considered the gold-standard, but the clear cut-off for normal eosinophilic counts are not yet defined as well as for other EGIDs such as eosinophilic esophagitis.…”

Section: Diagnosismentioning

confidence: 99%

Eosinophilic colitis: clinical review and 2020 update

Giudici

Ribaldone

Astegiano

et al. 2020

Minerva Gastroenterol Dietol

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“…Diarrhea is a valid indication for colonoscopy if it is chronic (more than three watery stools per day for at least four weeks) and once infective causes have been excluded. In these cases colonoscopy is demanded to rule out inflammatory bowel disease or, in cases of normal colonic mucosa, random colon biopsies may be useful to detect microscopic colitis [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Colon biopsies: benefit or burden?

Morărașu¹,

Haroon²,

Morăraşu³

et al. 2019

JMedLife

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Analyzing colon biopsies is becoming time consuming and a financial burden as colonoscopy is now the main screening and diagnostic procedure of the main gastrointestinal diseases. Colon sampling can provide important information when used accordingly; otherwise it may only load the medical system unnecessarily. Our aim was to retrospectively analyze criteria for colon biopsies and correlate the diagnostic value of randomly sampling colon, especially in patients with diarrhea. This was a retrospective study on 2109 colonoscopies done over one year. Data was collected from the ENDORAD system and included variables such as: age, gender, quality of preparation, procedure, symptoms, biopsies (type, location), and endoscopy and histology findings. Data was analyzed in a descriptive manner. Out of 496 random biopsies, only 7.4% had positive histology findings. The main symptom was diarrhea and 186 cases of patients complaining of diarrhea with normal colonoscopy had random colon sampling. In 5.3% of these cases histology assessment showed changes of microscopic colitis. Fisher’s test was significant when correlating the odds of having random biopsies in patients with and without diarrhea and patients younger and older than 60. Random sampling of colon during colonoscopies should be done only in selected patients otherwise it has a low diagnostic value.

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Microscopic colitis: a narrative review with clinical approach

Cited by 4 publications

References 60 publications

Current Status and Future Therapeutic Options for Fecal Microbiota Transplantation

Current Status and Future Therapeutic Options for Fecal Microbiota Transplantation

Eosinophilic colitis: clinical review and 2020 update

Colon biopsies: benefit or burden?

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