Microscopic evaluation of proliferative disorders in the gerbil female prostate: Evidence of aging and the influence of multiple pregnancies

Oliveira, Sergio Marcelino de; Santos, Fernanda C. A.; Corradi, Lara Sílvia; Góes, Rejane Maira; Vilamaior, Patrícia Simone Leite; Taboga, Sebastião Roberto

doi:10.1016/j.micron.2011.03.011

Cited by 8 publications

(6 citation statements)

References 43 publications

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“…The administration of P4 alone and concomitant with E2, which was employed in this investigation, showed the importance of epithelium-stroma interaction in the prostate gland, as treatment with these hormones improved the AR expression in stromal cells, allowing the recovery of prostate morphology, which was similar to that observed in control animals Cunha 2008). The epithelial hypertrophy observed in the gland of both sexes in the CaPT group resembles those studies in which animals were treated only with T, differentiating itself, however, by the presence of less epithelial dysplasia (Scarano et al 2006;Biancardi et al 2010;Oliveira et al 2011). In addition, in CaPT, the ARs are expressed mainly in the epithelium, in the same pattern as seen in NC animals (Omoto 2008).…”

Section: Discussionsupporting

confidence: 73%

“…The epithelial hypertrophy observed in the gland of both sexes in the CaPT group resembles those studies in which animals were treated only with T, differentiating itself, however, by the presence of less epithelial dysplasia (Scarano et al 2006;Biancardi et al 2010;Oliveira et al 2011). The prostate morphology observed in the CaP and CaPT animals indicates a non-synergistic pattern between the P4 and T. Shinohara et al (2013) demonstrated that administration of lower doses of P4 is also able to promote, in part, a restructuring of the prostate gland, but their association with T is not sufficient to decrease the installation of glandular lesions.…”

Section: Discussionsupporting

confidence: 61%

“…In addition, the AR-and ERa-positive cells were not changed, resembling the immunolabelling found in intact animals, and PR-positive cells were observed mainly at the prostate stroma. These changes found in the epithelial and stromal compartments are expected as, in both sexes, the correct balance of reproductive hormones is key to prostate gland development, differentiation and maintenance (Santos & Taboga 2006;Fochi et al 2008;Scarano et al 2008;Oliveira et al 2011). Studies in which testosterone replacement triggers accelerated processes of glandular development and recovery of prostate morphology confirm its relevance for the gland (Biancardi et al 2010).…”

Section: Discussionmentioning

confidence: 85%

“…Thus, the reduction in its levels probably causes the most intense consequences in the male prostate. These changes found in the epithelial and stromal compartments are expected as, in both sexes, the correct balance of reproductive hormones is key to prostate gland development, differentiation and maintenance (Santos & Taboga 2006;Fochi et al 2008;Scarano et al 2008;Oliveira et al 2011). In both sexes, after castration, the T/E2 ratio decreased mostly due the lower testosterone concentration in the CaC group, reducing the differences among serum levels of these two hormones.…”

Section: Discussionmentioning

confidence: 88%

“…Studies in which testosterone replacement triggers accelerated processes of glandular development and recovery of prostate morphology confirm its relevance for the gland (Biancardi et al 2010). However, the development of several kinds of lesions is commonly found in the prostate of testosteronetreated animals Scarano et al 2006;Oliveira et al 2011). In males, the prostate gland becomes more developed than in females due the greater amount of serum testosterone in the male organism (Thomson 2001;Thomson et al 2002).…”

Section: Discussionmentioning

confidence: 95%

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Progesterone as a morphological regulatory factor of the male and female gerbil prostate

Fochi

Santos

Góes

et al. 2013

Int J Experimental Path

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Testosterone (T) and oestrogen are the main active steroid hormones in the male and female reproductive system respectively. In female rodents progesterone (P4), together with testosterone and oestrogen, has an essential role in the regulation of the oestrous cycle, which influences the prostate physiology through their oscillations. In this work we investigated how the male and female prostate gland of Mongolian gerbils responds to surgical castration at the start of puberty and what are the effects of T, oestradiol (E2) and P4 replacement, using both quantitative and qualitative methods. We also examined the location of the main steroid receptors present in the prostate. In the castrated animals of both sexes an intense glandular regression, along with disorganization of the stromal compartment, and abundant hyperplasia was observed. The replacement of P4 secured a mild recovery of the glandular morphology, inducing the growth of secretory cells and restoring the androgen receptor (AR) cells. The administration of P4 and E2 eliminated epithelial hyperplasia and intensified gland hypertrophy, favouring the emergence of prostatic intraepithelial neoplasia (PIN). In animals treated with T and P4, even though there are some inflammatory foci and other lesions, the prostate gland revealed morphology closer to that of control animals. In summary, through the administration of P4, we could demonstrate that this hormone has anabolic characteristics, promoting hyperplasia and hypertrophy, mainly in the epithelial compartment. When combined with E2 and T, there is an accentuation of glandular hypertrophy that interrupts the development of hyperplasia and ensures the presence of a less dysplastic glandular morphology.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 95%

See 3 more Smart Citations

Progesterone as a morphological regulatory factor of the male and female gerbil prostate

Fochi

Santos

Góes

et al. 2013

Int J Experimental Path

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Gerbils

2017

Pathology of Small Mammal Pets

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Differences between male and female prostates in terms of physiology, sensitivity to chemicals and pathogenesis—A review in a rodent model

Sanches

Carvalho

Maldarine

et al. 2019

Cell Biology International

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The prostate is a gland that is not exclusively present in males, being also found in females of several mammalian species, including humans. There is evidence that the prostate in both sexes is affected by the same pathologies such as prostatitis, benign alterations and even cancer. In view of the difficulties of manipulating the prostate gland, the Mongolian gerbil (Meriones unguiculatus), a rodent species with high incidence of functional prostates in females, is widely used in studies of the female prostate. However, despite knowing much about the similarities between the female and male prostate, little emphasis has been placed on the differences between them. This review investigates the intersex differences in prostate development, physiology and pathogenesis. The female prostate develops earlier than in males and studies indicate that it is more sensitive to oestrogens than the male prostate, as well as being more sensitive to exposure to xenoestrogens, such as Bisphenol A and methylparaben, with a higher susceptibility to benign lesions in the adult and senile prostate than in males. In addition, the female prostate is impacted by pregnancy and the oestrous cycle, and is also dependent on progesterone. The peculiarities of the female prostate raise concerns about the risk of it undergoing neglected changes as a result of environmental chemicals, since safe dosages are established exclusively for the male prostate.

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Microscopic evaluation of proliferative disorders in the gerbil female prostate: Evidence of aging and the influence of multiple pregnancies

Cited by 8 publications

References 43 publications

Progesterone as a morphological regulatory factor of the male and female gerbil prostate

Progesterone as a morphological regulatory factor of the male and female gerbil prostate

Gerbils

Differences between male and female prostates in terms of physiology, sensitivity to chemicals and pathogenesis—A review in a rodent model

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