Microscopic Infrared Mapping of Chloromethylated Polystyrene Resin Beads

Abstract

In solid-phase combinatorial chemistry, analyses are performed using a wide range of analytical techniques ranging from gel-phase nuclear magnetic resonance (NMR) to colorimetric tests to elemental analysis. However, these techniques cannot be used to interrogate functional group distribution at the single-bead level. This paper explores the feasibility of using Fourier transform infrared (FT-IR) microscopy to examine site distribution on chloromethylated polystyrene resin beads and to quantify the loading after coupling with 4-cyanophenol, an IR tagging agent. FT-IR microscopy also provides a unique opportunity to better understand the reactivity of highly cross-linked polymer beads under a range of chemical conditions.

Synthesis and characterization of thiol-polystyrene microsphere and its adsorption properties of thallium

“…2. As shown in Fig 2, the C-Cl peak at 678 cm -1 after modification disappears, and a new peak appears at 2560 cm -1 , corresponding to -SH group 32 . This trend indicates that the thiol group replaced the chloromethyl group successfully and loaded on the microspheres.…”