Microscopic subinguinal varicocelectomy for testicular pain: a retrospective study on outcomes and predictors of pain relief

Al-Gadheeb, Abdullah; El-Tholoth, Hossam S.; Albalawi, Abdulaziz; Althobity, Abdulmajeed; Al-Numi, Mussa; Al-Afraa, Tala; Jad, Amr

doi:10.1186/s12610-020-00119-z

Cited by 9 publications

(5 citation statements)

References 22 publications

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“…Thereby, the testicle weight was increased by 36%. 17 The number of spermatozoa depicted in Figure 3 (a) and their rate of motility shown in Figure 3 (b) was decreased significantly in the ND group; the WS-treated group showed significant recovery from the damage caused by ND in both the sperm count as well as their motility rate. Based on the photoactometer study observed before treatment, the physical activity was higher in the ND and the drug intervention group.…”

Section: Discussionmentioning

confidence: 87%

Therapeutic Potential of Withania somnifera on Nandrolone Decanoate Induced Gonadal Toxicity

Sivanandam,

Senthilkumar,

Dipti

et al. 2024

Ind. J. Pharm. Edu. Res

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Background: Nandrolone decanoate (ND) is a commonly used androgen-based steroid that causes adverse effects on illicit self-administered users to boost their physical endurance. Although, it has an anabolic effect on the skeletal muscles, plausible evidence supports that the gonadal toxicity of ND can cause damage to reproductive functions. Aim: The present study investigated the possible protective effects of Withania somnifera (WS) root extract (200 and 400 mg/kg bw) on ND-induced (10 mg/kg bw) male gonadal toxicity in rats. Materials and Methods:The present seminal research was not experimented in any of the earlier studies. ND was induced in rats by intramuscular injection bi-weekly for 30 days. The aqueous extract of WS root powder was delivered orally once daily for 30 days to the ND-treated group. Hematoxylin-and-eosin-marked sections of the testes were studied. Results: The testosterone levels significantly decreased while there was an increase in the malondialdehyde levels among the ND-induced group against the control group. The ND induced rats treated with varying doses of WS showed a significant reversal of the gonadal toxicity by improvement in the testosterone and antioxidant parameters. The sperm count and sperm motility rate were increased significantly after WS therapy. Furthermore, the testis morphology of the WS-treated group indicated preserved germinal cells, active spermatogenesis, and absence of atrophy, vacuolation, and necrosis. Conclusion: WS treatment in ND-induced male rats alleviated the toxic effects of the ND on the gonads, probably due to its anti-inflammatory and antioxidant properties.

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Section: Discussionmentioning

confidence: 87%

Therapeutic Potential of Withania somnifera on Nandrolone Decanoate Induced Gonadal Toxicity

Sivanandam,

Senthilkumar,

Dipti

et al. 2024

Ind. J. Pharm. Edu. Res

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“…Park et al reported that a shorter time span from varicocele pain onset to surgery (<6 months) resulted in greater improvement in pain resolution ( p = 0.004) [ 39 ]. However, some studies revealed no significant differences between the duration of preoperative pain and pain relief [ 24 , 42 ].…”

Section: Predictors Of Treatment Outcomementioning

confidence: 99%

Scrotal Pain after Varicocelectomy: A Narrative Review

et al. 2023

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Varicocele is a frequently encountered urological disorder, which has a prevalence rate of 8 to 15% among healthy men. However, the incidence is higher in male patients with primary or secondary infertility, with up to 35 to 80% of varicocele cases occurring in this population. The clinical manifestations of varicocele typically include the presence of an asymptomatic mass that feels like a “bag of worms”, chronic scrotal pain, and infertility. Most patients with varicocele only undergo varicocelectomy after conservative treatments have failed. Unfortunately, some patients may still experience persistent scrotal pain due to a recurrence of varicocele, the development of hydrocele, neuralgia, referred pain, ureteral lesions, or nutcracker syndrome. Therefore, clinicians should consider these conditions as potential causes of postoperative scrotal pain, and take measures to address them. Several factors can assist in predicting surgical outcomes for patients with varicocele. Clinicians should consider these factors when deciding whether to perform surgery and what type of surgical intervention to use. By doing so, they can increase the likelihood of a successful surgical outcome and minimize the risk of complications such as postoperative scrotal pain.

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“…A significantly better pain relief is seen in patients with unilateral symptoms. 32 A systematic review and meta-analysis from Lundy et al found that 75%, 76%, 85%, and 90% of patients had partial or complete improvement of pain after undergoing varicocelectomy by inguinal, retroperitoneal, laparoscopic, and microsurgical approaches respectively. 33 Sheehan et al reported 50% and 89% complete pain resolution at 1-month and 1-year post varicocele treatment by embolization.…”

Section: Pain Resolutionmentioning

confidence: 99%

Review of various surgical approaches for varicocele management

Lumbiganon¹,

Yafi²,

Hammad³

et al. 2023

Insight Urol

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Varicocele is one of the most common correctable causes of male infertility. Varicocele can also cause scrotal pain or discomfort. Treatment of varicocele is proved to have benefits in terms of fertility and pain. There are many treatment options for varicocele. This review aims to describe the treatment procedures and determine the outcomes, advantages and disadvantages for each treatment option.

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Microscopic subinguinal varicocelectomy for testicular pain: a retrospective study on outcomes and predictors of pain relief

Cited by 9 publications

References 22 publications

Therapeutic Potential of Withania somnifera on Nandrolone Decanoate Induced Gonadal Toxicity

Therapeutic Potential of Withania somnifera on Nandrolone Decanoate Induced Gonadal Toxicity

Scrotal Pain after Varicocelectomy: A Narrative Review

Review of various surgical approaches for varicocele management

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