Microsegregating blends of ethyl cellulose and poly(vinyl pyrrolidone): a combined thermo-mechanical and positron annihilation spectroscopy study

Panzarasa, Guido; Osypova, Alina; Consolati, G.; Pandini, Stefano

doi:10.1007/s10570-018-2220-6

Cited by 7 publications

(2 citation statements)

References 29 publications

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“…Microstructural analysis revealed that increases in both the free volume hole size and fraction were caused by increasing the ethylcellulose concentration. The combined structural properties of the polymeric blend determine drug permeability and, therefore, drug release properties [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

Positron Annihilation Lifetime Spectroscopy as a Special Technique for the Solid-State Characterization of Pharmaceutical Excipients, Drug Delivery Systems, and Medical Devices—A Systematic Review

et al. 2023

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The aims of this systematic review are to explore the possibilities of using the positron annihilation lifetime spectroscopy (PALS) method in the pharmaceutical industry and to examine the application of PALS as a supportive, predictive method during the research process. In addition, the review aims to provide a comprehensive picture of additional medical and pharmaceutical uses, as the application of the PALS test method is limited and not widely known in this sector. We collected the scientific literature of the last 20 years (2002–2022) from several databases (PubMed, Embase, SciFinder-n, and Google Scholar) and evaluated the data gathered in relation to the combination of three directives, namely, the utilization of the PALS method, the testing of solid systems, and their application in the medical and pharmaceutical fields. The application of the PALS method is discussed based on three large groups: substances, drug delivery systems, and medical devices, starting with simpler systems and moving to more complex ones. The results are discussed based on the functionality of the PALS method, via microstructural analysis, the tracking of ageing and microstructural changes during stability testing, the examination of the effects of excipients and external factors, and defect characterization, with a strong emphasis on the benefits of this technique. The review highlights the wide range of possible applications of the PALS method as a non-invasive analytical tool for examining microstructures and monitoring changes; it can be effectively applied in many fields, alone or with complementary testing methods.

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Section: Resultsmentioning

confidence: 99%

Positron Annihilation Lifetime Spectroscopy as a Special Technique for the Solid-State Characterization of Pharmaceutical Excipients, Drug Delivery Systems, and Medical Devices—A Systematic Review

et al. 2023

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“…In literature; there are several studies about electrospinning of PVP nanofibers [24][25][26][27]. Hovewer there are limited studies about electrospinning optimization with Taguchi experimental design.…”

Section: Introductionmentioning

confidence: 99%

Electrospinning of PVP Nanofibers and Optimization with Taguchi Experimental Design

Pınarbaşı¹,

Çallıoğlu

2022

Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi

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The aim of this study is the determination of optimum process parameters which will provide the finest and the most uniform electrospun Polyvinylpyrrolidone (PVP) based nanofibers with Taguchi experimental design. For the designed experimental setup, parameters (solvent type, polymer concentration, voltage, distance between the electrodes, solution feed rate and humidity) were used which effect the electospinning process significantly. For this purpose, the appropriate orthogonal array was selected to determine the factors and levels at Taguchi experimental design application. The experimental design aimed which provides to be reduced the number of experiments and minimised the effect of uncontrollable factors with less experiments to obtain target value by using Taguchi orthogonal arrays. In the experimental studies of paper, firstly PVP polymer solutions such as conductivity, surface tension and viscosity were determined with various PVP concentrations (10, 12, 14 wt %) and solvents (ethanol, dimethylformamide, dimethylacetamide, chloroform, acetic acid and distilled water). Scanning Electron Microscope (SEM) images of electrospun PVP based nanofibrous surfaces were obtained, average fiber diameter and fiber diameter coefficient values were calculated by ImageJ image analyses software and fiber diameter distribution histogram curves were obtained by SPSS program. Experimental results were analyzed and commented by Taguchi method in MINITAB program with variance analysis. According to the results; solvent type has the highest effect on the electrospinning of PVP nanofibers. In this study, it is predicted to save in terms of time and cost with decreasing the number of experiments by Taguchi experiment design.

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Thermal and Mechanical Analysis of N ‐Vinyl Pyrrolidone and N ‐Vinyl Caprolactam‐Based Polymers

Johnson¹,

McMullen²

2021

Handbook of Pyrrolidone and Caprolactam Based Materials

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The techniques and methods used to measure thermal and mechanical properties are interrelated and routinely used to investigate the material properties of polymers. This chapter provides an overview of differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and dynamic mechanical analysis (DMA) and delve into their application to study polymers based on vinyl pyrrolidone and vinyl caprolactam. DSC is an extremely useful tool for investigating the behavior of blends of PVP, with other polymers providing insight into their interactions and miscibility. TGA is a thermal technique that is used to monitor changes in polymer structure as a function of temperature. The chapter provides an introduction to TGA followed by its application and use to characterize VP‐based polymers. DMA is essential to study the mechanical properties of polymers. DMA is also known as dynamic thermomechanical analysis, dynamic mechanical thermal analysis, forced oscillatory measurements, or dynamic rheology.

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Microsegregating blends of ethyl cellulose and poly(vinyl pyrrolidone): a combined thermo-mechanical and positron annihilation spectroscopy study

Cited by 7 publications

References 29 publications

Positron Annihilation Lifetime Spectroscopy as a Special Technique for the Solid-State Characterization of Pharmaceutical Excipients, Drug Delivery Systems, and Medical Devices—A Systematic Review

Positron Annihilation Lifetime Spectroscopy as a Special Technique for the Solid-State Characterization of Pharmaceutical Excipients, Drug Delivery Systems, and Medical Devices—A Systematic Review

Electrospinning of PVP Nanofibers and Optimization with Taguchi Experimental Design

Thermal and Mechanical Analysis of N ‐Vinyl Pyrrolidone and N ‐Vinyl Caprolactam‐Based Polymers

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