Microsomal and Thyroglobulin Antibodies in Thyroid Disorders

Sk, Dham; Ac, Anand; Dhananjayan, G; Kj, Shetty

doi:10.1016/s0377-1237(17)30984-x

Cited by 2 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dham et al , (1995) [23] observed that Anti-TPO positive in 58.3% of primary hypothyroidism and in 70% of primary thyrotoxicosis and in 100% of Hashimoto's disease and the study showed a significant elevation in IgG in Graves' disease.Another study by Sultana et al , (2016) [22] revealed that seropositivity of Anti-TPO in patients with hypothyroidism is about (54.54%) ,while in patients with hyperthyroidism is about ( 53.33% ) and approximately agreed with the current study , also its noticed that prevalence of Anti-TPO ,as well as Anti-TG together, comprise 69.09% in hypothyroidism and 66.66% in hyperthyroidism cases which indicate to high seropositivity when these autoantibodies are elevated together in patients. Swain et al , (2005) [24] observed that Anti-TPO is above 60% in hypothyroidism .…”

Section: Resultsmentioning

confidence: 92%

Study the association between IL-17 level and autoimmune antibodies in hypo and hyper thyroidisms patients

F.Fadhil

Ibraheem

Al-Kazaz

2019

eijs

View full text Add to dashboard Cite

The current study included measuring the level of IL-17A and IL-17F and some autoimmune antibodies related to the thyroid gland in case of hypo and hyperthyroid in Iraqi patients to evaluate the correlation between all the measured parameters in this study.The study has been carried out in AL-Kindey Endocrine Gland and Diabetic Center in Baghdad during the period between February 2018 and May 2018, included: 88 patients were divided into three groups, The first group composed of 30 patients of Hypothyroidism that included (26) of them were females, (4) of them males. The second group composed of 30 of patients of Hyperthyroidism that included (20) of them were females, (10) of them were males . and second groups were conducted with hypo and hyperthyroidism respectively.While the third group composed of 28 of healthy individuals (Control) that composed of (25) of them were females, (3) of them were males was represented as control .The results revealed a significant (P < 0.05) correlation between TSH concentration and age in patients groups. When the age is more than 40 years, the concentration of TSH was noticed to be higher than that in patients aged less than 40 years. The results show that the level of antibodies was significantly increased (P<0.01) in hypo and hyperthyroid patients in comparison with the control group. At the same time the level of Anti-TG antibodies was higher significantly in the hypothyroid patients than its level in hyperthyroid patients group. No significant differences have been found between hypo and hyperthyroid patients in the level of Anti-TPO and Anti TSH-R antibodies. But its noticed that the higher level of Anti-TPO Ab. was found in the hypothyroid group where as higher level of Anti TSH-R Ab. was found in the hyperthyroid group and simultaneously both types were significantly higher than their levels in the control group As well as the results demonstrated a highly significant increase (P< 0.01) in the levels of IL-17 Types (A and F) in hypo and hyperthyroid patients with bias toward the comparison with the control group. The statistical study showed a significant negative correlation between the level of TSH and Anti-TG levels (r= -0.33). While a significant positive correlation between the level of Anti-TG and level of IL-17F (r= 0.39) in hypothyroid patients. Also in hypothyroid patients, there is a significant positive correlation between the level of Anti-TPO and IL-17A (r= 0.33). In conclusion: The positive correlation between IL-17F and Anti-TG and between IL-17A and Anti- TPO in hypothyroid patients refer to increase in the concentration of IL-17 may lead to increase the thyroid autoantibodies, which affect thyroid tissue potency, decreasing thyroid hormone production, according to feedback inhibition loop.

show abstract

Section: Resultsmentioning

confidence: 92%

Study the association between IL-17 level and autoimmune antibodies in hypo and hyper thyroidisms patients

F.Fadhil

Ibraheem

Al-Kazaz

2019

eijs

View full text Add to dashboard Cite

show abstract

“…The thyroid scan (technetium-99 m pertechnetate scintigraphy) showed diffuse homogenous intake of technetium-99 m pertechnetate in both thyroid lobes ( Figure 3B ). Anti-microsomal antibody and anti-thyroglobulin antibody may be detected in Graves' disease (anti-microsomal antibody: 69.2%, anti-thyroglobulin antibody: 23–30%) ( 20 ); furthermore, with the results of TBII and the thyroid scan results, we diagnosed our patient as having type 1 amiodarone-induced thyrotoxicosis, a form of iodine-induced hyperthyroidism caused by excessive, uncontrolled biosynthesis of thyroid hormone by autonomously functioning thyroid tissue in response to iodine load, which typically develops in underlying latent Graves' disease ( 21 ). After consultation with the endocrinology department, methimazole (20 mg for 17 days followed by 5 mg/d) was used as treatment to manage excessive thyroid hormone synthesis.…”

Section: Case Reportmentioning

confidence: 99%

Amiodarone-Induced Multi-Systemic Toxicity Involving the Liver, Lungs, Thyroid, and Eyes: A Case Report

You

Yoon

Cho

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

ObjectivesAmiodarone is widely used to treat arrhythmia. However, amiodarone is known for its severe toxicity to the liver, lungs, and thyroid. Amiodarone causes liver damage ranging from asymptomatic serum aminotransferase elevation to hepatic failure requiring liver transplantation. Although amiodarone toxicity has been reported, its simultaneous multi-organ toxicity is not well-known. Here, we introduce a novel case of multi-systemic amiodarone toxicity involving the liver, lungs, thyroid, and eyes.Case PresentationA 61-year-old woman visited the emergency room due to general weakness, nausea, visual disturbance, heat intolerance, and a non-productive cough. The patient had been using clopidogrel and amiodarone due to underlying atrial fibrillation. The total level of bilirubin was 0.71 mg/dL, aspartate aminotransferase was 358 U/L, alanine aminotransferase was 177 U/L, and prothrombin time was 27.1 s. Computed tomography showed diffuse increased liver intensity and scattered hyperattenuated nodular consolidations in both lungs. Transthoracic needle lung biopsy revealed fibrinoid interstitial inflammation with atypical change of type II pneumocytes and intra-alveolar foamy macrophages. In addition, the thyroid-stimulating hormone level was <0.008 μIU/mL, and free thyroxine was 4.67 ng/dL. The thyroid scan showed diffuse homogenous intake of technetium-99 m pertechnetate in both thyroid lobes. The ophthalmologic exam detected bilateral symmetrical corneal deposits in a vortex pattern. With these findings, we could diagnose amiodarone-induced hepatic, pulmonary, thyroid, and ophthalmologic toxicity. Liver function was restored after cessation of amiodarone, and thyroid function was normalized with methimazole administration. However, due to aggravated lung consolidations, systemic steroid treatment was administered, and improvement was seen 1 week after, at the follow-up exam. As her symptoms improved, she was discharged with a plan of steroid administration for 3 to 6 months.ConclusionsThis case implies the possibility of multi-systemic amiodarone toxicity. Thus, the toxicity of amiodarone to multiple organs must be monitored. Prompt cessation of the drug should be considered upon diagnosis.

show abstract

Microsomal and Thyroglobulin Antibodies in Thyroid Disorders

Cited by 2 publications

References 7 publications

Study the association between IL-17 level and autoimmune antibodies in hypo and hyper thyroidisms patients

Study the association between IL-17 level and autoimmune antibodies in hypo and hyper thyroidisms patients

Amiodarone-Induced Multi-Systemic Toxicity Involving the Liver, Lungs, Thyroid, and Eyes: A Case Report

Contact Info

Product

Resources

About