Microstructural and network abnormalities in headache

Ellerbrock, Isabel; Engel, Andreas K.; May, Arne

doi:10.1097/wco.0b013e3283633714

Cited by 34 publications

(38 citation statements)

References 85 publications

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“…Furthermore, a recent study has revealed a higher sensitivity of surface‐based methods in the detection of structural changes in regions involved in EF in patients with migraine compared with HC. However, we believe that the discrepancies among previous morphological studies may be attributed to different factors, including patients sample size, analytic tools, and statistical methods …”

Section: Discussionmentioning

confidence: 92%

“…Consistent with our previous study, the decreased ECN functional connectivity is not correlated to GM atrophy or WM abnormalities. It is well known that some studies have supported migraine association with morphological abnormalities likely correlated to migraine subtypes and disease severity . In particular, Schmitz et al have shown a significant correlation between slow executive response and reduced frontal and parietal lobe GM density in a group of patients including both MwoA and MwA .…”

Section: Discussionmentioning

confidence: 98%

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Abnormal Connectivity Within Executive Resting‐State Network in Migraine With Aura

et al. 2015

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Abnormal Connectivity Within Executive Resting‐State Network in Migraine With Aura

et al. 2015

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“…However, several studies have found associations between the presence of pain disorders and atypical cortical thickness, including several migraine studies. [42], [43], [44], [45], [46] It is possible that aberrant cortical thickness of pain sensing and pain modulating regions determines sensitivity to somatosensory stimuli and thus predefines a person's pain perception in terms of pain thresholds, pain intensity and/or pain unpleasantness. [47] Alternatively, recurrent pain might lead to alterations in cortical thickness.…”

Section: Discussionmentioning

confidence: 99%

Correlations between Brain Cortical Thickness and Cutaneous Pain Thresholds Are Atypical in Adults with Migraine

Schwedt

Chong

2014

PLoS ONE

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Background/ObjectiveMigraineurs have atypical pain processing, increased expectations for pain, and hypervigilance for pain. Recent studies identified correlations between brain structure and pain sensation in healthy adults. The objective of this study was to compare cortical thickness-to-pain threshold correlations in migraineurs to healthy controls. We hypothesized that migraineurs would have aberrant relationships between the anatomical neurocorrelates of pain processing and pain thresholds.MethodsPain thresholds to cutaneously applied heat were determined for 31 adult migraineurs and 32 healthy controls. Cortical thickness was determined from magnetic resonance imaging T1-weighted sequences. Regional cortical thickness-to-pain threshold correlations were determined for migraineurs and controls separately using a general linear model whole brain vertex-wise analysis. A pain threshold-by-group interaction analysis was then conducted to estimate regions where migraineurs show alterations in the pain threshold-to-cortical thickness correlations relative to healthy controls.ResultsControls had negative correlations (p<0.01 uncorrected) between pain thresholds and cortical thickness in left posterior cingulate/precuneus, right superior temporal, right inferior parietal, and left inferior temporal regions, and a negative correlation (p<0.01 Monte Carlo corrected) with a left superior temporal/inferior parietal region. Migraineurs had positive correlations (p<0.01 uncorrected) between pain thresholds and cortical thickness in left superior temporal/inferior parietal, right precuneus, right superior temporal/inferior parietal, and left inferior parietal regions. Cortical thickness-to-pain threshold correlations differed between migraine and control groups (p<0.01 uncorrected) for right superior temporal/inferior parietal, right precentral, left posterior cingulate/precuneus, and right inferior parietal regions and (p<0.01 Monte Carlo corrected) for a left superior temporal/inferior parietal region.ConclusionsUnlike healthy control subjects who have a significant negative correlation between cortical thickness in a superior temporal/inferior parietal region with pain thresholds, migraineurs have a non-significant positive correlation between cortical thickness in a superior temporal/inferior parietal region with pain thresholds. Since this region participates in orienting and attention to painful stimuli, absence of the normal correlation might represent a migraineurs inability to inhibit pain sensation via shifting attention away from the painful stimulus.

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“…We found overall comparable prevalence of white matter lesions in both CH patient (37%) and control (32%) groups. These numbers are higher than most of the previous reports [for reviews, see Hougaard et al, 2014;Kruit et al, 2004Kruit et al, , 2005, which primarily employed 1.5T MRI and computed tomography images in the analysis [Eller and Goadsby, 2013;Ellerbrock et al, 2013]. We Widely distributed CT abnormality in CLBP relative to CON CLBP groups (49 pairs).…”

Section: Table II Cortical Regions Showed Significantly Differences mentioning

confidence: 73%

Cortical thickness and functional connectivity abnormality in chronic headache and low back pain patients

Yang

Wang

Yang

et al. 2017

Human Brain Mapping

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This study aims to characterize the psychological wellbeing of chronic headache (CH) patients, to identify cortical structural abnormalities and any associations of those abnormalities with resting state functional connectivity (rsFC), and to determine whether such rsFC abnormality is specific to CH patients. Compared with healthy controls (CON ), CH patients suffered from mild depression, sleep disturbances, and relatively poor quality of life. CH patients also exhibited widespread cortical thickness (CT) abnormalities in left premotor (BA6), right primary somatosensory (S1) and right prefrontal (BA10) cortices, as well as in regions of default mode and executive control networks. Using cortical regions with thickness abnormality as seeds, we found cortical region pairs showed strengthened rsFC in CH patients. Using the same seeds, rsFC analysis from chronic low back pain (CLBP) patients and their controls (CON ) identified abnormalities in non-overlapping cortical region pairs. Direct comparison of rsFC between CH and CLBP patients revealed significantly differences in thirteen cortical region pairs, including the four identified in CH and CON comparison. Across all three groups (CH, CLBP and CON), the rsFC between left multisensory association area (BA39) and left posterior cingulate cortex (BA23) differed significantly. Eight regions showed CT abnormality in CLBP patients, two of which overlapped with those of CH patients. Our observations support the notion that CH and CLBP pain are pathological conditions, under which the brain develops distinct widespread structural and functional abnormalities. CH and CLBP groups share some similar structural abnormalities, but rsFC abnormalities in several cortical region pairs appear to be pathology-specific. Hum Brain Mapp 38:1815-1832, 2017. © 2017 Wiley Periodicals, Inc.

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Microstructural and network abnormalities in headache

Cited by 34 publications

References 85 publications

Abnormal Connectivity Within Executive Resting‐State Network in Migraine With Aura

Abnormal Connectivity Within Executive Resting‐State Network in Migraine With Aura

Correlations between Brain Cortical Thickness and Cutaneous Pain Thresholds Are Atypical in Adults with Migraine

Cortical thickness and functional connectivity abnormality in chronic headache and low back pain patients

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