Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites

Vassal, Mariana; Nunes-Pereira, J.; Miguel, Sónia P.; Correia, Ilídio J.; Silva, Abílio P.

doi:10.1016/j.ceramint.2019.01.122

Cited by 21 publications

(15 citation statements)

References 58 publications

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“…Further forsterite addition up to 40 mass% partially improved the apparent porosity. In agreement with Vassal et al and Castkova et al [18,19], we believe that sintering at high temperature (1300°C) enhanced agglomeration for MH 1 and MH 2 composites, which in turn minimized the sinterability and increased the porosity of the material. The slight improvement in the apparent porosity of MH 4 samples may be due to the effect of the higher content of forsterite on the formation of the glassy phase, which enhanced pore closure.…”

Section: Physical Propertiessupporting

confidence: 92%

Forsterite/nano-biogenic hydroxyapatite composites for biomedical applications

Naga

Hassan

Awaad

et al. 2020

Journal of Asian Ceramic Societies

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Recently, silicate materials have received attention as materials with promising applications in the bioceramics field. A recent study aimed to investigate the effect of forsterite (Mg 2 SiO 4) addition to biogenic hydroxyapatite, Ca 10 (PO 4) 6 (OH) 2 , on the phase formation, physical and mechanical properties, and biocompatibility of the produced composites. Different proportions of forsterite, 10 to 40 mass%, were added to hydroxyapatite obtained from fish bones to prepare the target composites. Various techniques, such as X-ray diffraction analysis (XRD), scanning electronic microscope (SEM), transmission electronic microscope (TEM), mechanical strength measurements and in vitro studies, were carried out to evaluate the composite properties. The results indicate that the addition of 20 to 40 mass% forsterite led to the transformation of forsterite into protoenstatite and the formation of Mg-rich whitlockite at the expense of hydroxyapatite. It is concluded that 20 mass% forsterite is the optimum addition amount to enhance the physical and mechanical properties of the produced composites. The cell culture tests and in vitro studies agree with the abovementioned results.

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Section: Physical Propertiessupporting

confidence: 92%

Forsterite/nano-biogenic hydroxyapatite composites for biomedical applications

Naga

Hassan

Awaad

et al. 2020

Journal of Asian Ceramic Societies

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“…Hydroxyapatite, in combination with TiO 2 /yttria-stabilized zirconia/alumina /nanodiamond/magnesium, or a natural fiber, has been used to produce HA composites to enhance bioactivity and mechanical properties of scaffolds for bone implant applications [116]. Similarly, the ZnO/SiO 2 or Ag 2 O-doped plasma-sprayed hydroxyapatite coating was also prepared with improved mechanical and antibacterial activities for orthopedic and dental applications [117][118][119]. These nHA coatings have shown increased antibacterial properties and high biocompatibility indispensable for biomedical applications.…”

Section: Effect Of Irradiation On Antibacterials and Bioactivity Of H...mentioning

confidence: 99%

Chemical Bonding of Biomolecules to the Surface of Nano-Hydroxyapatite to Enhance Its Bioactivity

et al. 2022

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Hydroxyapatite (HA) is a significant constituent of bones or teeth and is widely used as an artificial bone graft. It is often used to replace the lost bones or in reconstructing alveolar bones before dental implantation. HA with biological functions finds its importance in orthopedic surgery and dentistry to increase the local concentration of calcium ions, which activate the growth and differentiation of mesenchymal stem cells (MSC). To make relevant use of HA in bone transplantation, the surfaces of orthopedic and dental implants are frequently coated with nanosized hydroxyapatite (nHA), but its low dispersibility and tendency to form aggregates, the purpose of the surface modification of bone implants is defeated. To overcome these drawbacks and to improve the histocompatibility of bone implants or to use nHA in therapeutic applications of implants in the treatment of bone diseases, various studies suggested the attachment of biomolecules (growth factors) or drugs through chemical bonding at the surface of nHA. The growth factors or drugs bonded physically at the surface of nHA are mostly unstable and burst released immediately. Therefore, reported studies suggested that the surface of nHA needs to be modified through the chemical bonding of biologically active molecules at the surface of bone implants such as proteins, peptides, or naturally occurring polysaccharides to prevent the aggregation of nHA and to get homogenous dispersion of nHA in solution. The role of irradiation in producing bioactive and antibacterial nHA through morphological variations in surfaces of nHA is also summarized by considering internal structures and the formation of reactive oxygen species on irradiation. This mini-review aims to highlight the importance of small molecules such as proteins, peptides, drugs, and photocatalysts in surface property modification of nHA to achieve stable, bioactive, and antibacterial nHA to act as artificial bone implants (scaffolds) in combination with biodegradable polymers.

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“…When comparing all calcium phosphate-containing bioceramics, HA is the most applied for medical purposes due to its biocompatibility with a living organism and a chemical composition similar to bone. In fact, biocomposite materials could achieve different mechanical and biological properties [12][13][14]. Furthermore, the contact between the biocomposite and the surrounding tissue may be a function of the components [15][16].…”

Section: Introductionmentioning

confidence: 99%