Microstructure of polymer hydrogels studied by pulsed field gradient NMR diffusion and TEM methods

Bernin, Diana; Goudappel, Gert-Jan; Ruijven, Marjolein van; Altskär, Annika; Ström, Anna; Rudemo, Mats; Hermansson, Anne‐Marie; Nydén, Magnus

doi:10.1039/c1sm05070b

Cited by 36 publications

(25 citation statements)

References 33 publications

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“…In this direction, the research community is moving toward the use of direct and independent diffusivity measurements to avoid all these issues 2. 63, 64 Despite the fact that concentration‐gradient diffusivity and self‐diffusivity present some differences, the literature has provided several correlations23, 65 to relate them. These correlations take into account the hindered contribution of hydrogels in terms of porosity and tortuosity, underlining that the two values are in good agreement if we consider small molecules within bigger pores 23…”

Section: Resultsmentioning

confidence: 99%

Drug–Polymer Interactions in Hydrogel‐based Drug‐Delivery Systems: An Experimental and Theoretical Study

et al. 2015

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In drug-delivery systems, drug transport is a key step, but the interpretation of the transport mechanism is still controversial. Here, we investigated a promising hydrogel library loaded with the anticonvulsant drug ethosuximide (ESM). The self-diffusion coefficient of ESM was measured using two methods: a direct and advanced measurement with a pulsed field gradient spin-echo (PFGSE) method, using an NMR spectrometer equipped with high-resolution magic angle spinning (HR-MAS) probe, and an indirect one based on fitting in vitro drug-delivery data. Starting from the experimental data a mathematical model without fitted parameters was developed and all the phenomena involved, that is, adsorption and diffusion, were considered. At low drug concentrations, adsorption prevails and consequently the diffusivity in the gels is lower than that in water. At high drug concentrations, where all adsorption sites are saturated, the diffusion in the gels is similar to that in a water solution. This study may pave the way for better device design.

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Section: Resultsmentioning

confidence: 99%

Drug–Polymer Interactions in Hydrogel‐based Drug‐Delivery Systems: An Experimental and Theoretical Study

et al. 2015

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“…There is no need for sample preparation for the imaging and hence have found profound use in the characterization of the biological samples [197] . Transmission electron microscope (TEM) is being used to image very tiny objects in the order of few nm [198,199] . The principle of operation of the microscope is similar to that of SEM with an exception that very thin-layered=small-sized samples are being used and the energy of the electron beam used is very high.…”

Section: Mucoadhesivitymentioning

confidence: 99%

Hydrogel-Based Controlled Release Formulations: Designing Considerations, Characterization Techniques and Applications

Pal

Singh

Anis

et al. 2013

Polymer-Plastics Technology and Engineering

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Hydrogels have evolved over the last decade as materials of choice in varied biomedical applications. This is associated with the inherent biocompatible nature of the hydrogels. The modulation of the properties of the hydrogels is easily possible due to the availability of polymers of varied chemistry and physical properties. This review discusses the pharmaceutical aspects of the controlled release of bioactive agents from hydrogel-based formulations.

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“…For additives having sizes similar to the matrix network the effects are more complex, and aggregation of the additive is an important factor. 19 Nanofillers having strong interaction with the matrix have been 70 reported to increase the storage modulus of the composite far more than expected from traditional filler theory. 20,21 On the other hand, alginate gels prepared using glycerol or low molecular weight dextran as additives displayed an increased viscosity in the gel liquid phase but did not show any changes in storage modulus.…”

Section: Introductionmentioning

confidence: 99%

A novel dual-structure, self-healable, polysaccharide based hybrid nanogel for biomedical uses

2011

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Notice: Changes introduced as a result of publishing processes such as copy-editing and formatting may not be reflected in this document. For a definitive version of this work, please refer to the published source. Please note that access to the published version might require a subscription. Chalmers Publication Library (CPL) offers the possibility of retrieving research publications produced at Chalmers University of Technology. It covers all types of publications: articles, dissertations, licentiate theses, masters theses, conference papers, reports etc. Since 2006 it is the official tool for Chalmers official publication statistics. To ensure that Chalmers research results are disseminated as widely as possible, an Open Access Policy has been adopted. The CPL service is administrated and maintained by Chalmers Library.

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Microstructure of polymer hydrogels studied by pulsed field gradient NMR diffusion and TEM methods

Cited by 36 publications

References 33 publications

Drug–Polymer Interactions in Hydrogel‐based Drug‐Delivery Systems: An Experimental and Theoretical Study

Drug–Polymer Interactions in Hydrogel‐based Drug‐Delivery Systems: An Experimental and Theoretical Study

Hydrogel-Based Controlled Release Formulations: Designing Considerations, Characterization Techniques and Applications

A novel dual-structure, self-healable, polysaccharide based hybrid nanogel for biomedical uses

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