Microsurgery for the treatment of primary malignant intracranial melanoma: A surgical series and literature review

Wang, J.; Guo, Zongze; Wang, Y.-J.; Zhang, S.-G.; Xing, Deguang

doi:10.1016/j.ejso.2013.11.024

Cited by 24 publications

(42 citation statements)

References 34 publications

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“…PIMM predominantly originates from the leptomeningeal melanocytes. These cells are found underneath the brain and the brainstem, inside the ventricles, at the optic chiasm, in the grooves of the various lobes, in the substantia nigra and in the choroid16). Primary spinal cord melanoma is rare, but has been reported previously 9).…”

Section: Discussionmentioning

confidence: 96%

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Primary Intracranial Malignant Melanoma with Extracranial Metastasis

Hirota

Yoshimura

Kubo

et al. 2017

J Korean Neurosurg Soc

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We report a case of primary intracranial malignant melanoma (PIMM) with extracranial metastases. The patient was an 82-year-old woman diagnosed with PIMM under the left cerebellar tentorium. We performed a tumor resection followed by gamma knife surgery. An magnetic resonance imaging at 11 months after surgery showed a local intracranial recurrence. At 12 months, vertebral metastasis was suspected, and 2-[fluorine-18]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) showed multiple extracranial metastases. She died at 13 months after surgery. Although extracranial metastases of PIMM are extremely rare, we should carefully follow up extracranial metastases together with intracranial ones, especially by FDG-PET/CT, even at an early asymptomatic stage.

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Section: Discussionmentioning

confidence: 96%

“…The median survival for patients with MIMM is only 5–6 months while patients with PIMM survive 9–24 months. Individuals have been reported to survive for more than 5 years 5,6,12–14,16).…”

Section: Discussionmentioning

confidence: 99%

Primary Intracranial Malignant Melanoma with Extracranial Metastasis

Hirota

Yoshimura

Kubo

et al. 2017

J Korean Neurosurg Soc

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Section: Discussionmentioning

confidence: 99%

“…Primary intracranial melanomas are thought to be developed from melanocytes, predominantly from the leptomeningeal melanocytes, that originated at the neural crest and migrated during embryogenesis 16) . These cells are found underneath the brain and the brainstem, inside the ventricles, at the optic chiasm, in the grooves of the various lobes, in the substantia nigra, and in the choroid 16) . And most reported lesions of primary melanomas were found in the spinal canal or the posterior fossa because of the higher concentration of leptomeningeal melanocytes at the anterior and lateral surface of the spinal cord and ventrolateral to the medulla oblongata 14) .…”

Section: Discussionmentioning

confidence: 99%

Primary Malignant Melanoma in the Pineal Region

Park

Hong

2014

J Korean Neurosurg Soc

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A 59-year-old male patient had 5-month history of gait disturbance and memory impairment. His initial brain computed tomography scan showed 3.5×2.8 cm sized mass with high density in the pineal region. The tumor was hypointense on T2 weighted magnetic resonance images and hyperintense on T1 weighted magnetic resonance images with heterogenous enhancement of central portion. The tumor was totally removed via the occipital transtentorial approach. Black mass was observed in the operation field, and after surgery, histopathological examination confirmed the diagnosis of malignant melanoma. Whole spine magnetic resonance images and whole body 18-fluoro-deoxyglucose positron emission tomography could not demonstrate the primary site of this melanoma. Scrupulous physical examination of his skin and mucosa was done and dark pigmented lesion on his left leg was found, but additional studies including magnetic resonance images and skin biopsy showed negative finding. As a result, final diagnosis of primary pineal malignant melanoma was made. He underwent treatment with the whole brain radiotherapy and extended local boost irradiation without chemotherapy. His preoperative symptoms were disappeared, and no other specific neurological deficits were founded. His follow-up image studies showed no recurrence or distant metastasis until 26 weeks after surgery. Primary pineal malignant melanomas are extremely rare intracranial tumors, and only 17 cases have been reported since 1899. The most recent case report showed favorable outcome by subtotal tumor resection followed by whole brain and extended local irradiation without chemotherapy. Our case is another result to prove that total tumor resection with radiotherapy can be the current optimal treatment for primary malignant melanoma in the pineal region.

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“…About 70.6% of melanoma patients had cerebral metastasis at younger than 65 years of age [4]. It is also one of the most common tumor types leading to intracranial hemorrhage [5,6] and even multiple hemorrhages [2,[4][5][6][7]. In addition to having a hemorrhagic presentation, MM may have three subtypes of imaging features on MRI: melanoma, non-melanoma and uncertain/mixed.…”

Section: Discussionmentioning

confidence: 99%

Intracerebral malignant melanoma presenting as an Arteriovenous Malformation: case report and literature review

et al. 2017

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Background: The authors introduced a rare case of intracranial malignant melanoma. Case presentation: A 32 year-old male patient presented to the hospital with signs and symptoms commonly seen in the presentation of a hemorrhagic stroke. The patient was diagnosed as having an Arteriovenous Malformation (AVM) after a thorough history, physical examination and radiographic imaging were performed and assessed. However, intraoperative findings and postoperative histopathology findings revealed that the supposed AVM was in fact a malignant melanoma, appearing as an AVM of the brain, on radiographic imaging. Conclusion: After reviewing related literature, our team realized that it was a rare finding for a melanoma pretending as a brain AVM.

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Microsurgery for the treatment of primary malignant intracranial melanoma: A surgical series and literature review

Cited by 24 publications

References 34 publications

Primary Intracranial Malignant Melanoma with Extracranial Metastasis

Primary Intracranial Malignant Melanoma with Extracranial Metastasis

Primary Malignant Melanoma in the Pineal Region

Intracerebral malignant melanoma presenting as an Arteriovenous Malformation: case report and literature review

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