Microtubes with Rectangular Cross-Section by Self-Assembly of a Short β-Peptide Foldamer

Kim, Jangbae; Kwon, Sunbum; Kim, Su Hyun; Lee, Chung-Kyung; Lee, Joon‐Hwa; Cho, Sung June; Lee, Hee-Seung; Ihee, Hyot Cherl

doi:10.1021/ja3088482

Cited by 66 publications

(44 citation statements)

References 33 publications

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“…SAPNs have been categorized from different perspectives, based on their indication, shape (cage-like, 2D lattices, nanofibers, etc. ), building block structures (cyclic, alpha-helix (α-helix), and β-sheets (β-sheets)) (Ardejani and Orner, 2013;Kim et al, 2012), building block source (natural or ab initio designed), design approaches, and many other features.…”

Section: Classification Of Sapnsmentioning

confidence: 99%

Harnessing self-assembled peptide nanoparticles in epitope vaccine design

Negahdaripour

Golkar

Hajighahramani

et al. 2017

Biotechnology Advances

107

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Vaccination has been one of the most successful breakthroughs in medical history. In recent years, epitope-based subunit vaccines have been introduced as a safer alternative to traditional vaccines. However, they suffer from limited immunogenicity. Nanotechnology has shown value in solving this issue. Different kinds of nanovaccines have been employed, among which virus-like nanoparticles (VLPs) and self-assembled peptide nanoparticles (SAPNs) seem very promising. Recently, SAPNs have attracted special interest due to their unique properties, including molecular specificity, biodegradability, and biocompatibility. They also resemble pathogens in terms of their size. Their multivalency allows an orderly repetitive display of antigens on their surface, which induces a stronger immune response than single immunogens. In vaccine design, SAPN self-adjuvanticity is regarded an outstanding advantage, since the use of toxic adjuvants is no longer required. SAPNs are usually composed of helical or β-sheet secondary structures and are tailored from natural peptides or de novo structures. Flexibility in subunit selection opens the door to a wide variety of molecules with different characteristics. SAPN engineering is an emerging area, and more novel structures are expected to be generated in the future, particularly with the rapid progress in related computational tools. The aim of this review is to provide a state-of-the-art overview of self-assembled peptide nanoparticles and their use in vaccine design in recent studies. Additionally, principles for their design and the application of computational approaches to vaccine design are summarized.

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Section: Classification Of Sapnsmentioning

confidence: 99%

Harnessing self-assembled peptide nanoparticles in epitope vaccine design

Negahdaripour

Golkar

Hajighahramani

et al. 2017

Biotechnology Advances

107

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“…The profile was matched -10 refinement, a pseudo-Voigt function, together with a manually interpolated background, was used to describe the peak shape. A detailed Rietveld refinement procedure for large organic molecules can also be found elsewhere [10][11][12].…”

Section: Experimental Methodsmentioning

confidence: 99%

Structure Transformation of Na-Mg Based Salts for CO2 Capture and Storage at High Temperature Probed with Variable Temperature X-ray Powder Diffraction

Lee

Kim

et al. 2014

Energy Procedia

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CO 2 sorption on the NaNO 3 incorporated MgO sorbent at 573-673 K has been resulted in the formation of MgCO 3 , referred from the results of in-situ X-ray powder diffraction combined with FT-IR spectrum. There was no interaction between CO 2 and NaNO 3 incorporated MgO sorbent before the melting of NaNO 3 . The fraction of MgCO 3 was increased significantly while the NaNO 3 phase in the MgO sorbent was melted at around 580 K. Further it was demonstrated that the use of eutectic mixture having a low melting point, 496 K, 12 wt% NaNO 3 and 8 wt% KNO 3 impregnated on MgO lower the temperature for CO 2 sorption to ca. 498 K. Therefore, it was suggested that the dissolution of CO 2 in liquid metal nitrate was a critical step for the CO 2 capture as Mg carbonate salts.

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“…Furthermore they can provide antibacterial, 6 antiviral, 7 and cell-penetrating activity, 8 as well as having self-assembling properties. 9 This may lead to applications in pharmaceutics or bionanotechnology.…”

Section: Introductionmentioning

confidence: 99%