Microtubules as Active Tracks for Bi-Directional Cellular Traffic of Motor Proteins

Satarić, M. V.; Budinski-Petković, Lj.; Lončarević, Ivana

doi:10.1142/s0217979207038368

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…There are at least three well-studied mechanical functions of the cytoskeleton in vivo; providing mechanical strength of the cell, segregating the chromosomes in cell division and active participation in the transport of macromolecules via motor proteins, primarily kinesin, dynein and myosin [2,3,4].…”

Section: Introductionmentioning

confidence: 99%

Ionic Pulses along Cytoskeletal Protophilaments

Satarić

2011

J. Phys.: Conf. Ser.

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Abstract. The experimental evidences regarding ionic waves generation and propagation along both microtubules (M Ts) and actin filaments (AFs) motivated us to develop the physical models that provide the framework for the explanation and analysis of these interesting biophysical phenomena.In pertaining analysis we partly relied on some experimental as well as numerical data, but also on theoretical estimations enabling us to establish the concept of nonlinear transmission lines which could lead to reasonable clearing up of experimental facts.We are convinced that these ionic currents actually exist and serve to sustain some important biological cellular mechanisms.

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Section: Introductionmentioning

confidence: 99%

Ionic Pulses along Cytoskeletal Protophilaments

Satarić

2011

J. Phys.: Conf. Ser.

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“…Microtubules (MTs), polymers of tubulin dimers, are considered to be involved in various tasks including cell morphology, intracellular transport, chromosome segregation, cell stiffness control, memory, consciousness and pathogen infections. [1,2] In vivo MT cylinders have 13 protofilaments, as shown in Fig. 1(a).…”

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confidence: 99%

Microtubule as a Transmission Line for Ionic Currents

Ilić

Satarić

Ralević

2009

Chinese Phys. Lett.

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We establish a new model for ionic waves along microtubules based on polyelectrolyte features of cylindrical biopolymers. The nonlinear transmission line described by a nonlinear differential equation is obtained with stable kink solution pertinent to the shape of the front of accompanying potential. The localized ionic wave could be used to explain the behavior of microtubules as biomolecular transistors capable of amplifying electrical information in neurons.

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A nonlinear model of ionic wave propagation along microtubules

et al. 2009

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Microtubules (MTs) are important cytoskeletal polymers engaged in a number of specific cellular activities including the traffic of organelles using motor proteins, cellular architecture and motility, cell division and a possible participation in information processing within neuronal functioning. How MTs operate and process electrical information is still largely unknown. In this paper we investigate the conditions enabling MTs to act as electrical transmission lines for ion flows along their lengths. We introduce a model in which each tubulin dimer is viewed as an electric element with a capacitive, inductive and resistive characteristics arising due to polyelectrolyte nature of MTs. Based on Kirchhoff's laws taken in the continuum limit, a nonlinear partial differential equation is derived and analyzed. We demonstrate that it can be used to describe the electrostatic potential coupled to the propagating localized ionic waves.

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Microtubules as Active Tracks for Bi-Directional Cellular Traffic of Motor Proteins

Cited by 4 publications

References 14 publications

Ionic Pulses along Cytoskeletal Protophilaments

Ionic Pulses along Cytoskeletal Protophilaments

Microtubule as a Transmission Line for Ionic Currents

A nonlinear model of ionic wave propagation along microtubules

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