Microvascular proliferation in congenital vascular malformations of skin and soft tissue

Meijer-Jorna, Lorine B.; Loos, Chris M. van der; Boer, Onno J. de; Horst, Chantal M.A.M. van der; Wal, Allard C. van der

doi:10.1136/jcp.2006.038885

Cited by 40 publications

(36 citation statements)

References 20 publications

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“…As in extraskeletal VM, there can be foci of small channels, cuboidal endothelium, or organizing thrombi, which mimic a proliferative lesion. Evidence of proliferative activity reflected by MIB1 expression has been observed in some cutaneous, soft tissue, and cerebral vascular malformations [15][16][17]. We have also found evidence of proliferative activity in some venous malformations, but the proliferative index was low.…”

Section: Discussionmentioning

confidence: 61%

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Vascular lesions of bone in children, adolescents, and young adults. A clinicopathologic reappraisal and application of the ISSVA classification

et al. 2008

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Vascular lesions of bone are rare and their terminology is not standardized. Herein, we report 77 patients with such lesions in order to characterize their morphologic spectrum and the applicability of the International Society for the Study of Vascular Anomalies (ISSVA) classification. In this system, malformations are structural anomalies distinguishable from tumors, which are proliferative. The radiologic images/reports and pathologic materials from all patients were reviewed. All lesions were either restricted to bone or had minimal contiguous soft tissue involvement with the exception of some multifocal lymphatic lesions that extensively affected soft tissue and/or viscera. We found that certain lesions of bone often regarded as tumors should be classified as malformations. Malformations (n = 46) were more common than tumors (n = 31); lymphatic and venous malformations were equally frequent. In the tumor category, hemangioendothelioma and epithelioid hemangioma were the most common. We also describe new vascular entities that arise in or involve bone. Utilizing the ISSVA approach, the diverse and often contradictory terminology of vascular lesions of bone can be largely eliminated. Standardized nomenclature is critical for scientific communication and patient management, and we hereby recommend the ISSVA classification be applied to vascular lesions of bone, just as for skin, soft tissue, and viscera.

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Section: Discussionmentioning

confidence: 61%

“…Hypertrophy of the skeletal element(s) may ensue. Lesional change in size associated with microvascular proliferation, attributed to rheologic factors, may occur, particularly in areas with substantial shunting [15]. The molecular basis for AVMs is an area of active investigation.…”

Section: Discussionmentioning

confidence: 99%

Vascular lesions of bone in children, adolescents, and young adults. A clinicopathologic reappraisal and application of the ISSVA classification

et al. 2008

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“…The suffix "oma" implies increased endothelial turnover. However, as Meijer-Jorna et al (16) and Dellinger (17) have shown, there is no cellular proliferation in LMs.…”

Section: Introductionmentioning

confidence: 93%

“…The findings revealed thrombosis (2), an increase in mesenteric or mediastinic fat density (10), pleural effusion (8), pericardial effusion (2), ascites (5), gastrointestinal wall thickening (11), interlobular septa thickening (3), an increase in the number of adenopathies (5), associated LMs (16), and bone lesions (7).…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Primary Intestinal Lymphangiectasia and its Association With Generalized Lymphatic Anomaly

Marugán

López‐Gutiérrez

2016

J Pediatr Rev

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Background: Lymph is a fluid originating in the interstitial spaces of the body that contains cells, proteins, particles, chylomicrons, and sometimes bacteria. Objectives: The aim of the present study is to demonstrate that primary intestinal lymphangiectasia (PIL) results from a disruption of lymphatic circulation, thus corresponding to a secondary rather than a primary event in the context of generalized lymphatic anomaly. Materials and Methods:In this case series and record review, an analysis of intestinal lymphatic involvement was performed on patients diagnosed with PIL between 1965 and 2013. Of the 21 patients included in the study, 10 had been diagnosed before 5 years of age (1 prenatal), 8 between 5 and 18 years of age, and 3 while older than 18 years of age. The follow-up period varied between 1 and 34 years. Clinical data, blood and fecal parameters, imaging studies, endoscopy results, biopsy analyses, treatment details, and outcome information were collected from medical records. Endoscopy, histological studies, magnetic resonance imaging, and lymphoscintigraphy were performed on all patients. Dynamic intranodal lymphangiography was performed on 8 patients. Results: Central lymphatic channel obstruction was identified in 12 patients (57%). Associated lymphatic malformation (LM) was present in 16, diarrhea in 10, chylothorax in 11, chylous ascites in 10, pericardial effusion in 6, coagulopathy in 3, and osteolysis in 7. Conclusions: We consider intestinal lymphangiectasia not as an entity in itself, but as a consequence of lymphatic flow impairment in the thoracic duct, producing chylous reflux into the intestinal lymphatics.

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“…In a series 109 patients with symptomatic vascular malformations of soft tissue and skin, we observed small vessel masses in 30% of the excised lesions, which were nearly all (90%) of the arteriovenous type. 4 Clinically, these lesions are easier to follow than their counterparts in the heart, and we noticed that microvascular growth can occur episodically, also later in life, and is often associated with symptoms such as pain and swelling. Altogether, these observations may lead to the notion that arteriovenous malformations with intramuscular small vessels are not so harmless as suggested by the uneventful 30 months' follow-up of the patient presented by McCammond, and this is further illustrated by the fatal outcome of our two cases.…”

mentioning

confidence: 99%

Intramural small vessels in arteriovenous malformations of the heart: a note on prognostic significance

Meijer-Jorna¹,

Wal

2013

Cardiol Young

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Microvascular proliferation in congenital vascular malformations of skin and soft tissue

Abstract: Recognition of microvascular proliferation as a not uncommon feature, congenital arteriovenous malformations provide new insight into the growth behaviour and vascular composition of these lesions.

Cited by 40 publications

References 20 publications

Vascular lesions of bone in children, adolescents, and young adults. A clinicopathologic reappraisal and application of the ISSVA classification

Vascular lesions of bone in children, adolescents, and young adults. A clinicopathologic reappraisal and application of the ISSVA classification

Primary Intestinal Lymphangiectasia and its Association With Generalized Lymphatic Anomaly

Intramural small vessels in arteriovenous malformations of the heart: a note on prognostic significance

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