Microvascular Reactivity in Normotensive Subjects with a Familial Predisposition to Hypertension

Maver, Jerica; Štrucl, Martin

doi:10.1006/mvre.2000.2279

Cited by 15 publications

(14 citation statements)

References 18 publications

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“…Regarding the CAF in NT(ϩ) subjects, our results reveal that there is a significant decline of the parasympathetic drive, reflected by a decreased 30 max/15 min ratio and HF power, but not LF power. The result is compatible with another study that showed a decreased HF power in normotensive subjects with FHH (21), although some reports also have indicated an increase of LF power in normotensive subjects with FHH (22,23). Because all pre- BMI ϭ body mass index; DBP ϭ average of 2 seated diastolic blood pressure readings; HDL-C ϭ high-density lipoprotein cholesterol; HR ϭ average of 2 seated heart rate readings; MET-h ϭ metabolic equivalent-hours; NT(Ϫ) ϭ normotension without a family history of hypertension; NT(ϩ) ϭ normotension with a family history of hypertension; SBP ϭ average of 2 seated systolic blood pressure readings.…”

Section: Discussionsupporting

confidence: 94%

“…There has been a hospital-based study of CAF in subjects with high-normal blood pressure of 130 to 139/85 to 89 mm Hg (20), rather than the revised value of 120 to 139/80 to 89 mm Hg. The findings of CAF alteration in normotensive subjects with a family history of hypertension (FHH) have been inconsistent (21)(22)(23), and these studies define normotension as a blood pressure Ͻ140/90 mm Hg (21)(22)(23), not the revised value of Ͻ120/80 mm Hg. Furthermore, all of the aforementioned studies (20 -23) were not population-based.…”

Section: Discussionmentioning

confidence: 97%

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Epidemiological Study on the Effect of Pre-Hypertension and Family History of Hypertension on Cardiac Autonomic Function

Yang

et al. 2008

Journal of the American College of Cardiology

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 97%

Epidemiological Study on the Effect of Pre-Hypertension and Family History of Hypertension on Cardiac Autonomic Function

Yang

et al. 2008

Journal of the American College of Cardiology

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“…In persons suffering from family history of arterial hypertension the changes in reactivity of central derived microcirculation, which resulted from altered sympathetic -vagal balance, accompanied by decreasing of parasympathetic activity [1,2], were observed. Similar results was obtained in previous own researches on persons suffering from arterial hypertension [3].…”

Section: Discussionmentioning

confidence: 99%

Skin Microcirculation in Primary Arterial Hypertension

Tubek¹,

Sobieszczańska²

2012

J Clin Exp Cardiolog

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Laser Doppler Fluxometry (LDF) was used to assess basic flow (PP) of microcirculation (mc) of dorsal hand skin in 10 healthy persons of both sex (k) -of age 41,3 ± 7,18 years and 10 persons suffering from primary arterial hypertension (nt) -of age 41,3 ± 10,95 years. In obtained record it has beed evaluated: basic flow (PP -in arbitray units of perfusion -PU) and, by analysing frequency spectrum -heart rhythm (RS) and its variation (ZRS), respiratory rhythm (RO), myogenic rhythm of precapillary sphincters tone (RM) and its amplitude (RMa), neurogenic rhythm of precapillary sphincters tone (RN) and its amplitude (NRa) and endothelium-dependent rhythm of precapillary sphincters tone (RE) and its amplitude (REa). The rhythm was assessed in cycles per minute (Hz) and the amplitude by value of signal power in arbitrary units. Means (x¯ ) and standard deviations (± SD) were defined; differences were assessed using t-Student test.In the group of individuals, suffering from arterial hypertension, the decrease of heart rhythm variability, acceleration of respiratory rhythm and neurogenic rhythm on the microcirculation level was observed, what testifies to higher sympathetic activity. In people with arterial hypertension such regularity was not observed, which can prove the endothelium dysfunction.LDF enables complex, noninvasive assessment of circulatory system functioning that can be widely used in clinical practice, i.e. in order to monitor therapy effectiveness.

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“…However, only about 30 % of young subjects with a family history of hypertension developed significantly higher blood pressure at a later age of 22 as compared to those without a family history of hypertension [16]. In normotensives with a family history of hypertension increased low-frequency bands of the heart rate and blood pressure variability power spectra were shown [28,35]. Heart rate variability changes found in normotensive subjects are considered to be a good indicator of later hypertension development [8,21,29,43].…”

Section: Introductionmentioning

confidence: 99%

Autonomic nervous system activity in normotensive subjects with a family history of hypertension

2004

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This study was designed to address alterations in autonomic nervous system activity in normotensive subjects with a family history of hypertension. We compared the autonomic nervous system activity in 59 normotensives with a family history of hypertension and 46 normotensives with no family history of hypertension. Skin blood flow was measured using laser-Doppler method on the nailfold skin in the resting condition, during systemic cooling and during upright tilting. Finger blood pressure, pulse and ECG were monitored by a finapres device. Heart rate, systolic pressure and microvascular flow power spectral analyses were performed using fast Fourier transformation. Baroreflex sensitivity was estimated with the sequence method. Compared to the control group, normotensives with a family history of hypertension showed significantly higher systolic pressure, decreased proportion and area of the high-frequency band of the heart rate variability power spectrum and reduced baroreflex sensitivity in the resting condition as well as a decreased proportion and area of the high-frequency band of the heart rate variability power spectrum during systemic cooling. We also proved a different time course of baroreflex sensitivity during upright tilting in the two groups. In contrast, we did not find any significant differences in the parameters of systolic pressure and microvascular variability power spectra between the two groups. Our results indicate that even normotensives with a family history of hypertension exhibit an increased ratio of sympathetic to parasympathetic activity at the cardiac level; however, they do not show any alteration of the vascular sympathetic reactivity.

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Microvascular Reactivity in Normotensive Subjects with a Familial Predisposition to Hypertension

Cited by 15 publications

References 18 publications

Epidemiological Study on the Effect of Pre-Hypertension and Family History of Hypertension on Cardiac Autonomic Function

Epidemiological Study on the Effect of Pre-Hypertension and Family History of Hypertension on Cardiac Autonomic Function

Skin Microcirculation in Primary Arterial Hypertension

Autonomic nervous system activity in normotensive subjects with a family history of hypertension

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