Microvasculature, Blood Flow, and Vasoreactivity in Rabbit Sinus Mucosa After Surgery

Abstract

In this model, surgery does not seriously interfere with the sinus blood flow, although the regenerated mucosa did display an altered vasoreactivity. These findings should be considered in relation to the effects of surgery intended to limit local inflammation and to ensure the ventilation of the sinuses.

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

“…Im Regenerat lassen sich vor allem beim Erwachsenen[101] weniger ser ö se Dr ü sen[97] mit mehr Ausf ü hrungsg ä ngen[102] ) nachweisen. Das subepitheliale Stroma im Regenerat ist verdickt und die Gef ä ß anzahl erh ö ht[103] . Funktionell weisen nur gut die H ä lfte der F ä lle 18 Monate nach Nasennebenh ö hlenoperation eine nuklearmedizinisch normale mukozili ä re Clearance auf[104] .…”

Physiology and pathophysiology of respiratory mucosa of the nose and the paranasal sinuses

“…Especially in adults [101], the regenerated tissue shows less serous glands [97] with increased number of excretory ducts [102]. Subepithelial stroma of the regenerated tissue is thicker and the number of vessels is increased [103]. Only slightly more than half of all patients show a normal mucociliary clearance 18 months after sinus surgery if evaluated with nuclear medicine techniques [104].…”

Regeneration of Nerve Fibres in the Maxillary Sinus Mucosa after Experimental Surgery: An Immunocytochemical Double-labelling Study in the Rabbit

“…Furthermore, sympathetic denervation has been shown to be associated with increased sensitivity and prolonged responses to vasoconstrictor agents -especially h 2adrenoceptor agonists and NPY -in pig nasal mucosa in 6i6o (23). In a recent study on the revascularization and vasoreactivity of the sinus mucosa 1 month after surgery, the regenerated mucosa was found to be more sensitive to the vasocontrictor effect of the h 2 -adrenoceptor agonist oxymetazoline than was the non-operated control side (9). The more pronounced reduction in blood flow in consequence was attributed partly to the increased number of vessels capable of reacting to the pharmacological stimulation.…”

“…However, in the lamina propria, the serous glands are reduced in number, being largely replaced by fibrosis and a proliferation of vessels (5,9). Furthermore, sensitivity to a locally applied vasoconstrictor is increased, resulting in a more pronounced reduction of the blood flow in the regenerated sinus mucosa (9).…”