Microvessel density and regulators of angiogenesis in malignant and nonmalignant prostate tissue

Abstract

The aim of this study was to investigate the relationship between microvessel density (MVD), positive and negative angiogenic factors, and established prognostic factors in prostate cancer (PC), and, to clarify the effect of angiogenic factors to angiogenesis. The vascularization of neoplastic, non-neoplastic prostate tissue was determined by CD34 immunostaining. Angiogenetic mediators VEGF, bFGF, TSP-1, and p53 were studied by immunohistochemistry. Neovascularization and p53, VEGF, and TSP-1 expressions of tumorous tissue were higher than non-tumorous tissue. The bFGF expression in these tissues was not different. The p53 expression was not correlated with the expressions of VEGF, bFGF, and TSP-1 in PC. Our results demonstrate a significant increase in MVD, VEGF, TSP-1, and p53 expressions in prostate tumorigenesis. The pretreatment sPSA was the only parameter demonstrating significant correlation with tumor grade and may have a value in the prediction of aggressive tumor behavior in PC.

Microvessel density is not increased in prostate cancer: digital imaging of routine sections and tissue microarrays

“…Most analyzed parameters were higher within normal glandular prostatic tissue (MVC, MVA, vessel lumen), whereas MVAF, vessel wall, and vessel perimeters were not significantly different. These findings using the large representative areas contradict most previously published data with the hot spot method (average ROI size 0.15-0.19 mm 2 ), showing a 1.2-to 2-fold increase of MVD values in PC versus normal prostate [5,6,9,[28][29][30]. Recent large-scale TMA analyses of hot spots by Ebersdobler et al [5] also revealed 1.25-fold higher mean MVD in TMA spots with cancer versus non-cancerous tissue.…”

Angiogenesis in Paget's Disease of the Vulva and the Breast: Correlation with Microvessel Density

“…Increased MVD has been shown to be associated with disease progression and metastasis in several cancers, including vulval, breast, and prostate cancers [22–24]. A variety of endothelial cell markers have been used to identify microvessels for the purpose of counting.…”

Assessment of prostate cancer with integrated CT-perfusion using a sector-wise approach

“…[17,18] Studies have shown that MVD is higher in PCa than in benign prostate tissue. [19,20] Yeung et al [21] investigated the relation between MVD and PCa in vitro perfusion analyzed with micro-CT.…”